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Walnut peptide colon positioning mini-pills and preparation method thereof

A colon localization and pellet technology, applied in the field of new health food preparations, can solve problems such as reduced bioavailability

Inactive Publication Date: 2018-06-26
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of pellets is usually difficult to achieve good encapsulation efficiency and drug loading, and the impact of packaging materials on the release rate of active substances may directly lead to the reduction of bioavailability

Method used

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  • Walnut peptide colon positioning mini-pills and preparation method thereof
  • Walnut peptide colon positioning mini-pills and preparation method thereof
  • Walnut peptide colon positioning mini-pills and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Weigh 200g of walnut peptide, 650g of microcrystalline cellulose, 100g of lactose, and 50g of polyoxyethylene pyrrolidone through a 60-mesh sieve and mix evenly. 15rpm, roll into pellets in an extrusion spheronizer, the spheronization speed is 800rpm, the spheronization time is 5min, and then placed in a fluidized bed at 40°C to dry for 30min, passing through a 70-80 mesh sieve to obtain a 180-212μm pellet core.

Embodiment 2

[0074] Weigh 600g of walnut peptide, 350g of microcrystalline cellulose, 30g of cornstarch, and 20g of hydroxypropyl cellulose through a 60-mesh sieve and mix evenly. The output speed is 15rpm, rolled into pellets in the extrusion spheronizer, the spheronization speed is 1300rpm, the spheronization time is 4min, and then placed in a fluidized bed at 40°C for 30min, passed through a 20-28 mesh sieve to obtain a 600-830μm pellet core.

Embodiment 3

[0076] Weigh 400g of walnut peptide, 300g of microcrystalline cellulose, 170g of sodium starch octenyl succinate, 100g of galacto-oligosaccharide, and 30g of hydroxypropyl methylcellulose, pass through a 60-mesh sieve and mix evenly, then add 85% ethanol to make soft The material is extruded through a 150μm screen of an extrusion spheronizer at an extrusion speed of 20rpm, and rolled into pellets on an extrusion spheronizer at a spheronization speed of 600rpm and a spheronization time of 8min, and then placed in a fluidized bed at 40°C for 30min and dried for 90 to 115 Mesh sieve to get 125-160 μm ball core.

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Abstract

The invention relates to the technical field of a health-care food new preparation, in particular to walnut peptide colon positioning mini-pills and a preparation method thereof. Each of the walnut peptide colon positioning mini-pills provided by the invention consists of a pill core and a coating layer, wherein the pill cores are prepared from walnut peptide, an excipient, an adhesive and a wetting agent. For the prepared walnut peptide colon positioning mini-pills, the particle diameters are 10-2000[mu]m, the release degree in stimulated gastric juice within 120min is smaller than 2%, the release degree in stimulated intestinal fluid within 5h is smaller than 10%, and the release degree in stimulated colon fluid within 1h is greater than 95%. Compared with walnut peptide raw materials, the absorption efficiency in colons is obviously improved, and the health-care food new preparation has high oral administration biological availability. The walnut peptide colon positioning mini-pillsprovided by the invention can improve the spatial memory capacity of rats for the position of a platform, and increase the speed of the rats passing through a water maze.

Description

technical field [0001] The invention relates to the technical field of new health food preparations, in particular to a walnut peptide colon-localized pellet and a preparation method thereof. Background technique [0002] Walnut, also known as walnut, Qiang peach, long live seed, etc., is a plant of the genus Juglandaceae. At present, domestic research on walnuts is mainly based on dried walnuts. Although walnut processed products are gradually increasing, they are limited to walnut oil, walnut dew, walnut powder, amber walnut kernel and other products. The dry weight of protein in walnut accounts for 14-28%, which is a kind of high-quality plant protein resource. Walnut peptide, as an enzymatic hydrolysis extract of walnut dregs, contains 18 kinds of amino acids, including 8 kinds of essential amino acids for human body, and also contains more brain-building substances-aspartic acid, glutamic acid, arginine, etc., which have anti-inflammatory properties. Oxidation, antiba...

Claims

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Application Information

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IPC IPC(8): A23L33/18A23P10/30A23L29/30A23L29/00A23P30/20
CPCA23L29/015A23L29/03A23L29/30A23L33/18A23P10/30A23P30/20A23V2002/00A23V2200/30A23V2200/32
Inventor 马方励肖俊勇从仁怀刘卫许琦马忠华
Owner INFINITUS (CHINA) CO LTD
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