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Application of mannitol in preparing medicine for treating alzheimer disease and pharmaceutical composition

A technology of Alzheimer's disease and composition, which is applied in the application of medicine and the field of pharmaceutical composition, can solve the problem of unreported mannitol anti-ADAβ pathology and other problems

Pending Publication Date: 2019-04-23
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report in the existing literature that mannitol has anti-ADAβ pathological effects

Method used

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  • Application of mannitol in preparing medicine for treating alzheimer disease and pharmaceutical composition
  • Application of mannitol in preparing medicine for treating alzheimer disease and pharmaceutical composition
  • Application of mannitol in preparing medicine for treating alzheimer disease and pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] (1) Computer simulation experiment

[0020] Step 1: Construct the initial system of calculation simulation

[0021] 1.1 Download the Aβ42 monomer nuclear magnetic resonance structure (PDBID: 1Z0Q) from the protein structure database PDB (www.rcsb.org), and select the model 1 structure as the initial structure of the Aβ42 monomer (such as figure 1 shown);

[0022] 1.2 Construct its three-dimensional configuration according to the molecular formula of mannitol;

[0023] 1.3 Arrange the two Aβ42 monomer structures in parallel, and ensure that the minimum distance between the atoms of the two chains is greater than 10 angstroms

[0024] 1.4 For the mannitol-containing system, place six mannitol molecules randomly around the Aβ42 chain, and ensure that the distance between mannitol and Aβ42 atoms is greater than

[0025] 1.5 Construct a solvent box and add water molecules to the system. For a system without mannitol, the size of the solvent box is The number of wate...

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Abstract

The invention relates to the field of pharmaceutical chemistry, and discloses application of mannitol in preparing medicine for treating the alzheimer disease and a pharmaceutical composition. The pharmaceutical composition contains mannitol, pharmaceutically acceptable carriers, diluents or excipients. Mannitol can obviously reduce the deposition of cerebral cortex and hippocampus area Abeta of an AD sample and improve the space memory capability.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to the application and pharmaceutical composition of mannitol in the preparation of medicines for treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is a degenerative disease of the central nervous system with progressive cognitive impairment as the main clinical manifestation, and is the most common type of dementia. The anti-AD drugs that have been approved and widely used clinically are all symptomatic treatments and cannot change the progressive deterioration of AD. Therefore, the development of new anti-AD drugs has great scientific and social significance. [0003] Excessive accumulation of β-amyloid protein (amyloidβ-protein, Aβ) is one of the characteristic lesions of AD patients, and it is the upstream early event of AD. Existing mechanism studies have shown that the abnormal increase and aggregation of Aβ are closely related to the imba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/047A61P25/28
CPCA61K31/047A61P25/28
Inventor 杨莹王建枝段谟杰杨明晖柯丹
Owner HUAZHONG UNIV OF SCI & TECH
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