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Use of Shenzao Jiannao Oral Liquid in the Preparation of Drugs for Preventing and/or Treating Alzheimer's Disease

A technology of Alzheimer's disease and Jiannao oral liquid, applied in the field of biomedicine, can solve the problems of poor treatment effect of complex disease models, poor effect of senile dementia, complex pathogenesis, etc., and achieves improvement of brain tissue environment, The effect of promoting neurotrophic factor secretion and reducing apoptosis

Active Publication Date: 2021-06-29
DIAOYUTAI MEDICAL GRP JILIN TIANQIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this traditional Chinese medicine combination has the following defects: (1) the drug combination is aimed at a single disease model (1. Amanitic acid-induced rat AD model, 2. β-amyloid-induced AD rat model, 3. APP / PS1 transgenic mice (2) the drug combination can improve the learning and memory ability of AD model animals to a certain extent, and improve brain tissue damage , but it does not mention whether it can repair damaged neurons, and if the lost neurons cannot be effectively replenished and replaced, the long-term effect of its treatment of AD is limited
But there is following defect in this Chinese medicine combination: although this pharmaceutical composition can effectively alleviate the dementia symptom of vascular dementia model rat, it is not effective to more common, more complicated senile dementia (being Alzheimer's disease) of pathogenesis. good

Method used

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  • Use of Shenzao Jiannao Oral Liquid in the Preparation of Drugs for Preventing and/or Treating Alzheimer's Disease
  • Use of Shenzao Jiannao Oral Liquid in the Preparation of Drugs for Preventing and/or Treating Alzheimer's Disease
  • Use of Shenzao Jiannao Oral Liquid in the Preparation of Drugs for Preventing and/or Treating Alzheimer's Disease

Examples

Experimental program
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Effect test

Embodiment 1

[0051] 1. Preparation of AD mouse model with Aβ42 combined with scopolamine

[0052] 1. Animals: SPF grade Kunming mice, half male and half female, weighing 28-30 g, purchased from Liaoning Changsheng Biotechnology Co., Ltd., experimental animal production certificate number: SCXK (Liao) 2015-0001.

[0053] 2. Solution configuration: Aβ42 (purchased from Boaosen Biological Co., Ltd.) was dissolved in sterile normal saline, prepared to 1 μg / μL, and placed at 37°C for 24 hours; scopolamine hydrobromide (purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.) , add physiological saline to make 0.1mg / mL, and make it before use.

[0054] 3. Anesthesia: After being anesthetized with 20% urethane, fix it on a stereotaxic instrument, make a midline incision on the top of the head, and expose the bregma.

[0055] 4. Injection of Aβ42: Refer to the stereotaxic atlas of Franklin and Paxinos mice, take Bregma as the benchmark, 0.2 mm backward, 1.0 mm right, and 2.5-3 mm deep. ...

Embodiment 2

[0136] Comparative Experiment

[0137] According to a Chinese medicine composition disclosed in CN109925402A and a preparation method, the Chinese medicine composition includes the following raw materials in parts by weight: 2-15 parts of ginseng, 2-15 parts of fried jujube seed, 2-15 parts of roasted epimedium, 3-18 parts of Rehmannia glutinosa, 1-12 parts of Radix Polygalae, 1-12 parts of Bran-fried Atractylodes Rhizome, 3-18 parts of Angelica sinensis, 2-15 parts of Shichangpu, 1-10 parts of Zhigancao; especially according to the traditional Chinese medicine given therein The water decoction group of the composition was prepared: (1) Composition: 6g of ginseng, 6g of fried jujube seed, 6g of sunburned epimedium, 9g of rehmannia glutinosa, 5g of bran-fried Atractylodes macrocephala, 5g of polygala, 6g of Shichangpu, 9g of angelica, sunburnt Licorice 3g; (2) Preparation method: take angelica and wild jujube kernels, grind them into powder, decoct twice, add water to decoct tw...

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Abstract

The invention discloses a new application of Shenzao Jiannao Oral Liquid, especially the use of Shenzao Jiannao Oral Liquid in the preparation of drugs for preventing and / or treating Alzheimer's disease. The Shenzao Jiannao Oral Liquid is purchased from Tonghua Renmin Pharmaceutical Co., Ltd. is usually used to treat myocardial shortness of breath, insomnia, dreaminess, mental fatigue, weakness of waist and legs caused by neurasthenia. During the experiment, the present invention found that the drug can act on multiple pathogenesis links of AD, improve AD cognitive function, reduce Aβ deposition in brain tissue, inhibit cell apoptosis, inhibit oxidative stress, and promote the secretion of neurotrophic factors , Improve brain tissue environment, promote neuron survival, and improve cognitive function. Adding new indications for the clinical use of this product, and designing Shenzao Jiannao Oral Liquid as a multi-targeted drug for the treatment of AD has great application value.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the new application of Shenzao Jiannao Oral Liquid in the preparation of drugs for preventing and / or treating Alzheimer's disease (or known as senile dementia). Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a common central nervous degenerative disease in middle-aged and elderly people, with progressive memory loss and cognitive dysfunction as the main manifestations. With the aging population in our country, the incidence of AD is increasing year by year, and it has become a social and medical problem that needs to be solved urgently. The typical pathological features of AD are senile plaques and neurofibrillary tangles in the cerebral cortex and hippocampus, and the persistent inflammatory response and oxidative stress damage around the lesion lead to the loss of a large number of neurons and the atrophy of brain tissue. Alkaliergic neuron...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K9/08A61P25/28
CPCA61K9/0095A61K36/258A61K36/287A61K36/296A61K36/37A61K36/484A61K36/725A61K36/804A61K36/8988A61K36/9068A61P25/28A61K2300/00
Inventor 肖洪贺颜鑫颜忠辉
Owner DIAOYUTAI MEDICAL GRP JILIN TIANQIANG PHARMA
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