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Traditional Chinese medicine monomer compound compatibility preparation for treating cerebral ischemia and preparation method

A technology of cerebral ischemia and traditional Chinese medicine, which is applied in the field of preparing medicines for treating cerebral ischemia, and can solve problems such as low toxicity and side effects

Active Publication Date: 2017-09-08
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Erigeron breviscapus medicines have remarkable clinical application effects, have a long history of folk use, have a broad social foundation, and have little toxic and side effects, and are very popular among users. , but side effects such as rash, fatigue, dry mouth etc.

Method used

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  • Traditional Chinese medicine monomer compound compatibility preparation for treating cerebral ischemia and preparation method
  • Traditional Chinese medicine monomer compound compatibility preparation for treating cerebral ischemia and preparation method
  • Traditional Chinese medicine monomer compound compatibility preparation for treating cerebral ischemia and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0053] The present invention establishes the compound composition and compatibility ratio of monomers based on the effect analysis and analysis of main components of Danshen breviscapus in the compound preparation of traditional Chinese medicine.

[0054] (1) Experimental methods and materials

[0055] 1. Animal: adult mouse

[0056] C57BL / 6 mice on the 14th to 15th day of pregnancy, clean grade, healthy male C57BL / 6 mice, were provided by the Experimental Animal Center of Fourth Military Medical University. The animals were reared in the animal room of the Pharmacology Teaching and Research Office of the Fourth Military Medical University, with a temperature of 23±2°C, a humidity of 50%±10%, and a 12-h day and night cycle. Animals were free to eat and drink. Mice need to adapt to the environment for one week before the experiment, and all behavioral experiments are arranged during the day (9:00-12:00 am and 14:00-18:00 pm). All experiments on animals were approved by the Et...

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Abstract

The invention relates to a traditional Chinese medicine monomer compound compatibility preparation for treating cerebral ischemia. The preparation is characterized in that the medicinal active ingredients are formed by mixing tanshinone IIA with scutellarin; the tanshinone IIA has a structural formula as shown in the description, and the scutellarin has a structural formula as shown in the description as well. The preparation provided by the invention can be used for preparing medicine for ischemic encephalopathy, rehabilitation after cerebral hemorrhage, rehabilitation after cerebral thrombosis, and relief of myocardial ischemia and cerebral ischemia.

Description

technical field [0001] The invention relates to a compound compatible preparation of a pharmaceutical composition, a preparation method and an application of the pharmaceutical composition in preparing a medicine for treating cerebral ischemia. Background technique [0002] Cerebral stroke is a group of diseases that cause brain tissue damage due to sudden rupture or blockage of blood vessels in the brain, also known as stroke or cerebrovascular accident, with extremely high mortality and disability rates. In my country, more than 2 million people have new cerebrovascular diseases every year, and 1.5 million people die from the disease. About 3 / 4 of the survivors lose their ability to work to varying degrees, and about 1 / 4-1 / 3 Recurrence is possible within 2 to 5 years. The main target is people over 60 years old, and stroke has become a major disease that seriously threatens the health of middle-aged and elderly people. About 60%-80% of patients who survive after stroke ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K31/7048A61P9/10
CPCA61K31/58A61K31/7048A61K2300/00
Inventor 刘水冰招明高
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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