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Composition with sterilization protecting function and application of composition

A protective function and composition technology, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, drug combinations, etc., can solve the problem that chitosan has a short residence time and cannot effectively kill Helicobacter pylori and Candida albicans, etc., to achieve the effect of prolonging the residence time, high bactericidal effect, and prolonging the therapeutic effect

Inactive Publication Date: 2018-06-08
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In traditional treatment, dual therapy of antibiotics is often used together with gastric acid inhibitors or gastric mucosal protective agents. Antibiotic therapy requires long-term medication, which is undoubtedly worse for patients with fragile gastrointestinal tract. Although some data suggest that chitosan It plays a certain role in the treatment of gastric ulcer, but ordinary chitosan cannot effectively kill Helicobacter pylori and Candida albicans, and chitosan stays in the stomach for a short time, and enters the intestinal tract without fully exerting its effect

Method used

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  • Composition with sterilization protecting function and application of composition
  • Composition with sterilization protecting function and application of composition
  • Composition with sterilization protecting function and application of composition

Examples

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Embodiment 1 Embodiment 3

[0032] Embodiment one to embodiment three enumerate the composition of three kinds of different formulations;

Embodiment 4 Embodiment 9

[0033] Embodiment four to embodiment nine enumerate the manufacture method of six kinds of different formulation compositions;

[0034] Application Examples 1 to 6 correspond to the specific applications of the medicines prepared by the methods in Examples 4 to 9.

Embodiment 1

[0035] Embodiment one, a kind of composition with bactericidal protection function, is made up of the material of following ratio of parts: 1 part of chitosan; 3 parts of chitosan quaternary ammonium salt; 5 parts of sodium hyaluronate; 0.2 part of film-forming agent (0.1 part of lotus root extract, 0.1 part of lecithin); wherein: lotus root extract is obtained by the following method: (a) fresh lotus root is sliced, scalded in hot water for 20 seconds, and then crushed and pulped by a broken wall grinder; ( b) Add warm water to the prepared slurry, control the temperature at 45°C, pass the slurry through a 300-mesh nylon mesh, and collect the fine slurry that passes through the screen; (c) add deionized water to the obtained fine slurry to adjust the slurry The viscosity of the material is 150mPa.s, and it is placed in a centrifuge with a rotating speed of 4000r / s to separate the lower layer of slurry; (d) the collected slurry is sprayed and granulated, and then ground and cru...

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Abstract

The invention discloses a composition with a sterilization protecting function and application of the composition and relates to the field of medicine injection. The composition is prepared from the following materials in parts: 1 to 5 parts of chitosan, 1 to 3 parts of chitosan quaternary ammonium salt, 5 to 10 parts of sodium hyaluronate and 0.1 to 1 part of membrane-forming agent. By using thechitosan, the permeability of a cell outer membrane can be improved; a cell membrane is damaged by electrostatic interaction between the chitosan and the cell membrane and finally death of thallus iscaused; the positive ion of the chitosan quaternary ammonium salt is bonded with protein with negative charge in the thallus to form ions, and further the thallus is deactivated. Helicobacter pylori and candida albicans in stomach can be efficiently killed, stay time of the chitosan composition in intestines and stomach can be prolonged and the effect of prolonging the pharmaceutical effect of thechitosan is realized.

Description

technical field [0001] The invention relates to a composition with bactericidal protection function. Background technique [0002] Ulcer disease or peptic ulcer is a common digestive tract disease that can occur in the esophagus, stomach or duodenum, and can also occur near the gastro-jejunum anastomosis or in Meckel's diverticulum containing gastric mucosa, because gastric ulcer and Duodenal ulcer is the most common, so the so-called peptic ulcer generally refers to gastric ulcer and duodenal ulcer. The reason why it is called peptic ulcer is that gastric ulcer and duodenal ulcer were previously thought to be formed due to gastric acid and pepsin digesting the mucosa itself, but in fact gastric acid and pepsin are only one of the main causes of ulcer formation , there are other reasons for the formation of peptic ulcers. Because the etiology and clinical symptoms of gastric ulcer and duodenal ulcer have many similarities, sometimes it is difficult to distinguish between g...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61K9/50A61K47/36A61K47/46A61P31/04A61P31/10A61P1/04
CPCA61K9/0065A61K9/5036A61K9/5063A61K9/5073A61K31/722A61K2300/00
Inventor 赵澎车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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