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Mongolian medicine paste for child hyperpyrexia and preparation method and application method thereof

A pediatric high fever, patch technology, applied in the field of pharmaceutical preparations, can solve the problems of prolonged residence time, prolonged drug half-life, increased drug toxicity and side effects, etc., and achieves the effects of reducing inter-individual differences, reducing individual differences, and prolonging dosing intervals.

Inactive Publication Date: 2018-05-25
内蒙古民族大学附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional powder tastes bitter. When the drug is used to treat high fever in children, the compliance of children is poor, and it is difficult to take it, which affects the treatment.
In addition, the traditional oral administration method has the disadvantages of low drug availability and large gastrointestinal and systemic side effects, especially for infants and young children who are prone to high fever, whose liver system is immature and the liver detoxification function is insufficient. Prolonged metabolism and prolonged half-life of the drug increase the blood concentration and toxicity of the drug; infants with immature renal function and insufficient renal excretion function prolong the residence time of the drug and its breakdown products in the body, increasing the toxic and side effects of the drug. High-dose, high-frequency medication is unfavorable to its growth and development

Method used

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  • Mongolian medicine paste for child hyperpyrexia and preparation method and application method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] [Example 1: Clinical Experiment]

[0077] Fever is one of the most common symptoms in pediatric outpatient clinics. Clinically, rectal temperature > 38°C or axillary temperature > 37.5°C are usually defined as fever. Currently, there are two methods for treating high fever in children, one is physical cooling, and the other is Drug cooling, the combined use of the two will have a multiplier effect. In this experiment, Mongolian medicine Naoribu-7 acupoint application was used to treat children with high fever, combined with acetaminophen oral liquid for internal and external treatment. 116 cases of high fever children admitted to our hospital from June 2016 to June 2017 were selected for analysis. The specific report is as follows.

[0078] 1. Materials and methods

[0079] 1.1 General information

[0080] A total of 116 children with high fever admitted to our hospital from June 2016 to June 2017 were selected as the research objects, and they were divided into the ...

Embodiment 2

[0103] [Example 2: Acupoint Administration]

[0104] The method of selecting acupoints for drug administration according to acupoints is as follows:

[0105] Shuitu Point: Located on the neck of the human body, at the front edge of the sternocleidomastoid muscle,

[0106] Fushe point: in the lower abdomen, 4 inches below the middle of the navel, 4 inches away from the front midline,

[0107] Dazhui point: the depression under the spinous process of the seventh cervical vertebra,

[0108] Quchi point: in the depression of the elbow joint,

[0109] Neiguan point: above the horizontal stripes on the wrist,

[0110] Temple: where the eyebrows meet the outer corner of the eye,

[0111] Yangbai Point: The pupil is one inch above the eyebrow.

[0112] The principle of action of acupoint sticking

[0113] Acupoint sticking therapy is a non-invasive acupoint therapy. Since the meridians "innerly belong to viscera, outer network limbs, communicate with the outside and inside, and ...

Embodiment 3

[0118] [Example 3: analysis of medicinal properties]

[0119] Matrine and oxymatrine contained in Sophora flavescens are water-soluble drugs with poor fat solubility and low bioavailability. Pearl stalk, also known as Rubus Sachalinensis Leveile, also known as Rubus Sachalinensis Leveile in Mongolian, is the dry stem and branch of the Rosaceae plant Rubus Sachalinensis Leveile. Poor performance, low bioavailability, and insufficient biological activity limit its medicinal development. The geniposide contained in Gardenia jasminoides is highly polar, non-toxic, easily soluble in water, methanol and ethanol, and insoluble in lipophilic organic solvents such as chloroform, benzene, petroleum ether, etc. It is the main iridoid glycoside in Gardenia jasminoides It is also one of the main active ingredients of Mastia chinensis. Inulin mainly contains terpenoids, flavonoids, volatile oils, amino acids and polysaccharides. Sesquiterpenoids represented by inulin and isoinulin can inh...

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Abstract

The invention relates to the technical field of medicine preparations, in particular to a Mongolian medicine paste for child hyperpyrexia and a preparation method and application method thereof. Mongolian medicine eridun-7 soup is used as a powdery preparation for solving the problems that treatment is influenced due to poor adaptability and difficult application during child hyperpyrexia treatment. The oral powdery preparation is changed into an external use paste, extracts of all medicinal materials are used for replacing raw material medicine, and the treatment effect after use is better. The Mongolian medicine paste for child hyperpyrexia has the advantages that 1, the first-pass effect of the liver and degradation of the medicine in the gastrointestinal tract can be avoided, medicineabsorption is not influenced by gastrointestinal factors, and the individual difference of medicine application is reduced; 2, the medicine can enter the human body at the constant speed for a long time after one-time medicine application, the frequency of medicine application is reduced, and the interval of medicine application is prolonged; 3, the medicine application area is changed, the medicine application dosage is adjusted, and a patient takes the medicine by himself / herself; 4, the Mongolian medicine paste has the sustained or controlled release effect, the medicine can be slowly released at a certain speed, the constant plasma concentration is formed in the skin accordingly, and convenience is provided for prolonging the treatment time of the medicine.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a Mongolian medicine patch for children with hyperthermia and a preparation method and application method thereof. Background technique [0002] Mongolian medicine Eridun-7 Decoction (also known as Naoribu-7 Decoction), from "The Joy of the Viewer", consists of seven herbs such as Myrobalan, Gardenia, Toosendan, Tumuxiang, and Sophora flavescens. At the end, it is made into a powder, which can promote the maturity and convergence of febrile diseases, kill heat evils, and treat immature fever, epidemic fever, Heyi, and bloody fever. The traditional powder has a bitter taste. When this medicine is used for the treatment of high fever in children, the compliance of children is poor, and it is difficult to take it, which affects the treatment. In addition, the traditional oral administration method has the disadvantages of low drug availability and large gastroin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/906A61K9/70A61P29/00
CPCA61K9/7023A61K36/185A61K36/28A61K36/489A61K36/58A61K36/73A61K36/744A61K36/906A61K47/32A61K47/36A61K47/38A61K47/42A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 韩巧灵包淑花朱一坤张婉马诗哲冯婕黄光辉灵灵董静雪
Owner 内蒙古民族大学附属医院
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