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Preparation method of magnetic graphene oxide-protamine/sodium carboxymethyl cellulose composite and application

A technology of sodium carboxymethyl cellulose and protamine, which is applied in the field of material synthesis and biomedicine, can solve the problems of strong interaction between modified molecules and graphene oxide, harmfulness to human body, etc., and achieves easy large-scale production, low cost, The effect of reducing toxic side effects

Inactive Publication Date: 2018-05-11
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The functional modification of graphene oxide can be divided into covalent functionalization and non-covalent functionalization. The disadvantage of covalent modification is that the interaction between modified molecules and graphene oxide is very strong, and organic solvents are used in the preparation process. Cannot be completely removed and may be harmful to humans

Method used

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  • Preparation method of magnetic graphene oxide-protamine/sodium carboxymethyl cellulose composite and application
  • Preparation method of magnetic graphene oxide-protamine/sodium carboxymethyl cellulose composite and application
  • Preparation method of magnetic graphene oxide-protamine/sodium carboxymethyl cellulose composite and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: the synthesis of magnetic graphene oxide

[0035] Disperse an appropriate amount of graphene oxide in a mixed solvent of ethylene glycol and diethylene glycol, the concentration of graphene oxide is 2 mg / mL, sonicate the probe in an ice-water bath environment until it is completely dispersed, and then add ferric chloride hexahydrate to the solution , sodium acrylate and sodium acetate, the mass ratio of graphene oxide and ferric chloride hexahydrate is 1:10, the mass ratio of graphene oxide and sodium acrylate is 1:1, and the mass ratio of graphene oxide and sodium acetate is 1: 30. Mechanically stir evenly at room temperature, put the above solution into a reaction kettle, and react at 200°C for 24h. The sample is taken out, and the obtained sample after washing with water and alcohol is magnetic graphene oxide. The sample was dispersed into deionized water, and the magnetic graphene oxide solution was obtained by ultrasonication.

[0036] The magnetic fi...

Embodiment 2

[0038] Disperse an appropriate amount of graphene oxide in a mixed solvent of ethylene glycol and diethylene glycol, and the concentration of graphene oxide is 1 mg / mL. Ultrasonic the probe in an ice-water bath environment until it is completely dispersed, and then add ferric chloride hexahydrate to the solution , sodium acrylate and sodium acetate, the mass ratio of graphene oxide and ferric chloride hexahydrate is 1:15, the mass ratio of graphene oxide and sodium acrylate is 1:5, and the mass ratio of graphene oxide and sodium acetate is 1: 40. Mechanically stir evenly at room temperature, put the above solution into a reaction kettle, and react at 200°C for 24 hours. The sample is taken out, and the obtained sample after washing with water and alcohol is magnetic graphene oxide. The sample was dispersed into deionized water, and the magnetic graphene oxide solution was obtained by ultrasonication.

[0039] The magnetic field investigation results show that the synthesized ...

Embodiment 3

[0041] Disperse an appropriate amount of graphene oxide in a mixed solvent of ethylene glycol and diethylene glycol, the concentration of graphene oxide is 4 mg / mL, sonicate the probe in an ice-water bath environment until it is completely dispersed, and then add ferric chloride hexahydrate to the solution , sodium acrylate and sodium acetate, the mass ratio of graphene oxide and ferric chloride hexahydrate is 1:20, the mass ratio of graphene oxide and sodium acrylate is 1:10, the mass ratio of graphene oxide and sodium acetate is 1: 50, stir mechanically at room temperature, put the above solution into a reaction kettle, and react at 200°C for 24h. The sample is taken out, and the obtained sample after washing with water and alcohol is magnetic graphene oxide. The sample was dispersed into deionized water, and the magnetic graphene oxide solution was obtained by ultrasonication.

[0042] The magnetic field investigation results show that the synthesized magnetic graphene oxi...

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Abstract

The invention discloses a preparation method of a magnetic graphene oxide-protamine / sodium carboxymethyl cellulose composite material, and belongs to the technical field of material synthesis and biological medicine. The method specifically comprises the steps that magnetic graphene oxide prepared after a graphene derivative loads ferroferric oxide serves as a matrix, a layer-by-layer self-assembly technology is adopted, and the matrix is sequentially coated with protamine and sodium carboxymethyl cellulose to form the composite. According to the method, the layer-by-layer self-assembly composite material has superparamagnetism and good dispersion performance and stability in water; natural protamine sulfate and sodium carboxymethyl cellulose are utilized as polyelectrolyte, nano-sized magnetic graphene oxide serves as a core, and all the materials have good biocompatibility; the material has certain magnetism, antineoplastic drugs are loaded on the cores of carriers, drug loading is stable, the drug loading quantity is large, and the drugs can have a targeted and sustained release function and better exert the therapeutic effect.

Description

technical field [0001] The invention belongs to the technical field of material synthesis and biomedicine, and in particular relates to a preparation method and application of a magnetic graphene oxide-protamine / sodium carboxymethyl cellulose composite material. Background technique [0002] At present, cancer has become the primary enemy that threatens human life and health, and traditional treatment methods have poor treatment results due to serious side effects. With the development of science and technology, the use of drug carriers for targeted therapy of cancer to improve efficacy and reduce side effects has opened up new ideas for cancer treatment. There are various types of anticancer drug carriers discovered so far, including organic materials (such as proteins, lipids), inorganic materials, and polymer materials. Because organic materials and polymer materials have defects such as easy degradation, easy leakage of drugs and high cost as drug carriers, in order to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K41/00A61K47/04A61K47/38A61K47/42A61K31/704A61P35/00B01J31/06
CPCA61K9/5115A61K9/5161A61K9/5169A61K31/704A61K41/00B01J31/06
Inventor 谢萌杨娜徐远国张峰张雅楠杨眉
Owner JIANGSU UNIV
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