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Preparation method of shape memory fiber membrane with adjustable fiber surface micropore structure and application of drug release of membrane

A technology of memory fiber and microporous structure, which is applied in non-active ingredient medical preparations, drug delivery, pharmaceutical science, etc., can solve problems such as uncontrollable drug loading, achieve drug loading and drug release, and simple preparation process Effect

Active Publication Date: 2018-05-01
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of uncontrollable drug release process and low drug loading capacity of existing drug-loaded materials, the present invention proposes a preparation method of a shape memory fiber membrane with adjustable fiber surface microporous structure and its drug release application

Method used

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  • Preparation method of shape memory fiber membrane with adjustable fiber surface micropore structure and application of drug release of membrane
  • Preparation method of shape memory fiber membrane with adjustable fiber surface micropore structure and application of drug release of membrane
  • Preparation method of shape memory fiber membrane with adjustable fiber surface micropore structure and application of drug release of membrane

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specific Embodiment approach 1

[0037] Embodiment 1: In this embodiment, the preparation method of the shape memory fiber membrane with adjustable fiber surface microporous structure is carried out according to the following steps;

[0038] Dissolve the biodegradable polymer in an organic solvent and stir at room temperature until the polymer is completely dissolved to obtain a polymer solution; transfer the polymer solution into the syringe of the electrospinning device, and use the electrospinning device to dissolve the polymer solution Electrospinning to obtain a shape memory fiber membrane with adjustable microporous structure on the fiber surface;

[0039] The biodegradable polymer is one or more of polylactic acid, polycaprolactone and polyurethane mixed in any proportion.

[0040] The diameter of the fiber in the shape memory fiber membrane with adjustable fiber surface microporous structure obtained by the preparation method of this embodiment is 500 nm to 5 μm; The surface of the fiber in the prepa...

specific Embodiment approach 2

[0041]Specific embodiment two: the difference between this embodiment and specific embodiment one is: the organic solvent is dichloromethane, chloroform, N,N-dimethylformamide, N,N-dimethylacetamide One or more mixtures mixed in any proportion. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0042] Embodiment 3: This embodiment is different from Embodiment 1 or Embodiment 2 in that: the mass concentration of the polymer solution is 8-15%. Other steps and parameters are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses a preparation method of a shape memory fiber membrane with an adjustable fiber surface micropore structure and an application of drug release of the membrane, relates to a preparation method of a shape memory fiber membrane and an application of the membrane, and aims to solve the problems that the drug release process of an existing drug loading material cannot be controlled, and drug loading capacity is low. The preparation method of the shape memory fiber membrane includes the steps: dissolving polymer in an organic solvent to obtain polymer solution; transferring the polymer solution into electrostatic spinning forming. A drug release method includes the steps: preparing the drug-loading shape memory fiber membrane with the adjustable fiber surface micropore structure; performing stretching treatment and drug blocking; taking shape memory recovery measures to the drug-blocked shape memory fiber membrane to perform shape memory recovery. The fiber surface ofthe fiber membrane prepared by an electrostatic spinning process is provided with the uniform micropore structure, the drug loading capacity is high, the size and the shape of the fiber surface micropore structure can be adjusted by heating treatment or ultrasonic treatment, and drug loading and drug release are realized.

Description

technical field [0001] The invention relates to a preparation method and application of a shape memory fiber membrane. Background technique [0002] As one of the smart polymers, shape memory polymers can realize sensing, driving and control, and change their shape under external excitation conditions. The main excitation methods include heat, electricity, light, magnetism, microwave, chemical solvents, etc. . Because of this characteristic, shape memory polymers are widely used in space expandable structures, biomedical devices, information carriers, smart clothes and other fields. With the demand of practical applications, micro-sized porous structure materials have received attention, especially in biomedical fields, such as drug release, cell culture, tissue engineering, etc. Electrospinning is a common method used to prepare shape memory polymer micro-nano fibers, which is characterized in that a variety of shape memory polymers can be prepared into fiber structures, ...

Claims

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Application Information

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IPC IPC(8): D04H1/728D01F1/08A61L31/06A61L31/16A61L31/14A61K47/34
CPCA61K47/34A61L31/041A61L31/06A61L31/148A61L31/16A61L2300/602A61L2400/16D01F1/08D04H1/728
Inventor 张风华冷劲松刘彦菊王亚立
Owner HARBIN INST OF TECH
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