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Hydrogel near infrared light drug controlled-release system based on black phosphorus and preparation method thereof

A near-infrared light and hydrogel technology, which is applied in the field of biomedical nanomaterials, can solve the problems of difficult clinical application of hydrogel drug carriers, low photothermal conversion efficiency of photosensitive nanoparticles, and difficult clinical application, and is suitable for industrialization. production, non-toxic and side effects, and the effect of improving clinical curative effect

Inactive Publication Date: 2018-04-27
张晗 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the photosensitive nanoparticles (such as gold nanoparticles) currently used for light-controlled release have low photothermal conversion efficiency and are not degradable, which brings difficulties to clinical application.
[0004] Recent studies have found that black phosphorus two-dimensional materials have great application potential in the biomedical field, especially in cancer treatment, due to their low toxicity, high biocompatibility, high extinction coefficient and high photothermal conversion efficiency. It is necessary to develop a black phosphorus-based hydrogel light-controlled drug release system to solve the problem of difficult clinical application of existing hydrogel drug carriers

Method used

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  • Hydrogel near infrared light drug controlled-release system based on black phosphorus and preparation method thereof
  • Hydrogel near infrared light drug controlled-release system based on black phosphorus and preparation method thereof
  • Hydrogel near infrared light drug controlled-release system based on black phosphorus and preparation method thereof

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Embodiment 1

[0037] A method for preparing a black phosphorus-based hydrogel near-infrared light-controlled drug release system, comprising the following steps:

[0038] (1) Preparation of black phosphorus nanoflakes by solution stripping combined with probe ultrasonic method: take 50 mg block black phosphorus material, place it in 100 mL ultrapure water, and carry out probe ultrasonic, and the ultrasonic time of the probe ultrasonic method is 12 hours , the process is continuous ultrasonication for 45 seconds, waiting for 15 seconds as a cycle, and the power amplifier is 20%; after the ultrasonication is over, take the brown-black stripping solution and put it in a centrifuge tube, centrifuge at 1000rpm for 10 minutes at 4°C, and the precipitate has not been stripped block black phosphorus, and carefully separate the precipitated block black phosphorus and the black phosphorus nanoflakes in the supernatant to further purify and separate the black phosphorus nanoflakes;

[0039] (2) Disper...

Embodiment 2

[0048] A method for preparing a black phosphorus-based hydrogel near-infrared light-controlled drug release system, comprising the following steps:

[0049] (1) Preparation of black phosphorus nanoflakes by solution stripping combined with probe ultrasonic method: take 50 mg block black phosphorus material, place it in 100 mL ultrapure water, and carry out probe ultrasonic, and the ultrasonic time of the probe ultrasonic method is 18 hours , the process is continuous ultrasound for 1 hour, waiting for 1 hour as a cycle, and the power amplifier is 20%. After the ultrasound is over, take the brown-black stripping solution and put it in a centrifuge tube, centrifuge at 2000rpm for 6 minutes at 4°C to precipitate the unstripped massive black phosphorus, and carefully separate the precipitated massive black phosphorus from the supernatant Black phosphorus nano-flakes for further purification and separation of black phosphorus nano-flakes;

[0050] (2) Disperse the black phosphorus...

Embodiment 3

[0054] A method for preparing a black phosphorus-based hydrogel near-infrared light-controlled drug release system, comprising the following steps:

[0055] (1) Prepare black phosphorus nanoflakes by solution stripping combined with probe ultrasonic method, take 50 mg block black phosphorus material, place it in 100 mL ultrapure water, and carry out probe ultrasonic, and the ultrasonic time of the probe ultrasonic method is 16 hours , the process is continuous ultrasound for 1 hour, waiting for 1 hour as a cycle, and the power amplifier is 25%. After the ultrasound is over, take the brown-black stripping solution and put it in a centrifuge tube, centrifuge at 1000rpm for 15 minutes at 4°C to precipitate the unstripped massive black phosphorus, and carefully separate the precipitated massive black phosphorus from the supernatant Black phosphorus nano-flakes for further purification and separation of black phosphorus nano-flakes;

[0056] (2) Disperse the black phosphorus nano-...

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Abstract

The invention provides a hydrogel near infrared light drug controlled-release system based on black phosphorus, wherein the system includes an agarose hydrogel carrier, and a black phosphorus nano thin piece and an anticancer drug which are loaded in the agarose hydrogel carrier. The hydrogel near infrared light drug controlled-release system based on black phosphorus has near infrared light response, can realize the change of a gelation state to a sol state through near infrared light irradiation in a body, can locally controllably release the drug and effectively kills tumor cells in lesionlocations; the drug release system has the controllable degradation characteristics and has extremely high clinical value in treatment of cancer. The invention also provides a preparation method of the hydrogel near infrared light drug controlled-release system based on black phosphorus.

Description

technical field [0001] The invention relates to the technical field of biomedical nanomaterials, in particular to a black phosphorus-based hydrogel near-infrared light controlled drug release system and a preparation method thereof. Background technique [0002] Cancer is a serious threat to human life and health, and the current clinical treatment for cancer, whether it is chemotherapy, surgical treatment or radiotherapy, has great side effects on the body, and after malignant metastasis occurs, it is difficult to use any of the above methods. Completely healed. Although a lot of human, material and financial resources have been invested in cancer research, the progress is very limited, and the effective treatment of cancer is still a great test for mankind. [0003] Studies have shown that the application of biomacromolecules and nanotechnology to the field of cancer diagnosis and treatment has broad prospects and clinical value. Among them, the hydrogel drug carrier wit...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K41/00A61K47/36A61K47/04A61K47/18A61K31/704A61P35/00
CPCA61K9/06A61K31/704A61K41/0052A61K47/02A61K47/18A61K47/36A61K2300/00
Inventor 张晗仇萌
Owner 张晗
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