Preparation method of valpromide molecular imprinting electrochemical sensor

A provalerenamide, molecular imprinting technology, applied in the direction of electrochemical variables of materials, scientific instruments, instruments, etc., can solve the problems that functional monomers and template molecules cannot be properly matched, the sensitivity is not high, and the cross-linking rigidity is poor. Achieving excellent sensitivity, simple equipment, and easy production

Inactive Publication Date: 2018-04-20
GUANGXI UNIV FOR NATITIES
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Problems solved by technology

The current method is not sensitive because the selected functional monomers cannot be properly matched with the template molecules, and the rigidity of the cross-linking is also poor.

Method used

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  • Preparation method of valpromide molecular imprinting electrochemical sensor

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Embodiment 1

[0014] 1. Treatment of glassy carbon electrodes

[0015] The glassy carbon electrode was polished with 1.0 μm, 0.3 μm and 0.05 μm alumina powder on a polishing cloth in turn, then placed in nitric acid with a volume ratio of 1:1 for 8 minutes, and then placed in absolute ethanol for 8 minutes , and finally ultrasonically cleaned with pure water.

[0016] 2. Preparation of molecularly imprinted electrochemical sensor for valerenamide

[0017] To 10.0 mL of solvent ethanol, add 1.0 mmol of template molecule provalerianamide, 4.0 mmol of functional monomer young branch containing broken oxyloganin, 4.0 mmol of cross-linking agent N-trans-feruloyl tyramide, 0.11 The nano-clay of mmol initiator azobisisobutyronitrile and 0.0500 g, each adding a kind of chemical reagent ultrasonic dissolving for 8 minutes;

[0018] Take 8 μL of the mixture in step and apply it on the surface of a clean and smooth glassy carbon electrode with a diameter of 2 mm. After standing for 6 hours, place...

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Abstract

The invention discloses a preparation method of a valpromide molecular imprinting electrochemical sensor. The high-sensitivity valpromide molecular imprinting electrochemical sensor doped with nanometer clay is prepared by using valpromide as a template molecule, secoxyloganin as a functional monomer, azodiisobutyronitrile as an initiating agent, nanometer clay as a doping agent and N-trans-feruloyltyramine as a cross-linking agent. The analysis method is simple and practical; the defects of complexity, expensive equipment and low sensitivity of a conversional analysis method are overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a preparation method of a valerenamide molecularly imprinted electrochemical sensor. Background technique [0002] Valpromide, also known as dipropylacetamide. It is a new type of antiepileptic drug with broad spectrum, strong effect and quick effect. It has broad anticonvulsant effect without excitement and has sedative effect. It can be used for the treatment of various types of epilepsy. The main disadvantage is that long-term or excessive use of such drugs can cause liver and kidney damage and lupus erythematosus. [0003] The methods for determination of valerenamide include gas chromatography, gas phase-mass spectrometry, high performance liquid chromatography gradient elution method and solid phase extraction chromatography, etc. However, due to the need for expensive instruments and equipment, these methods have disadvantages such as high cost, long time...

Claims

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Application Information

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IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/308G01N27/48
Inventor 陈其锋马祥英余会成刘绍刚韦贻春
Owner GUANGXI UNIV FOR NATITIES
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