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Suppository containing periplaneta americana and preparation method of suppository

A technology of Periplaneta americana and suppositories, which is applied in the field of suppository preparation of Periplaneta americana extract, can solve the problems of inconvenient clinical use, etc., and achieve the effects of rapid onset of oral administration, good effect and fast absorption

Active Publication Date: 2018-04-20
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, Kangfuxin liquid has been used alone or combined with mesalamine, lidocaine and other drugs to treat ulcerative colitis through retention enema, but the clinical use is relatively inconvenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Using Periplaneta americana as raw material, dry and pulverize Periplaneta americana to 80 mesh, add 10 times the weight of 80% ethanol solution, reflux extraction twice, each time for 0.5h, filter, combine the filtrates, and concentrate to a clear liquid with a relative density of 1.10. paste, add 8 times the amount of water for extraction, and spray-dry the aqueous layer extract to make a dry powder. Take another mixed fatty glyceride, put it in a 40°C water bath to dissolve, add the obtained extract powder, macrogol glyceride, castor oil, glycerin, cholic acid, paraben, etc. and stir well, the weight ratio is 80:5: 2: 2: 3: 1: 1, pour it into the cooled suppository mold coated with liquid paraffin while it is hot until it slightly overflows the mold mouth, after cooling and solidifying, use a knife to cut out the overflowing part, push out the suppository, and let it dry , to obtain a fat-soluble drug-containing suppository.

Embodiment 2

[0019] Using Periplaneta americana as raw material, dry and crush the Periplaneta americana to 80 mesh, add 8 times the weight of 70% ethanol solution, reflux for extraction for 1 hour, filter, concentrate the filtrate into a clear paste with a relative density of 1.10, add 10 times the amount of water For extraction, the aqueous layer extract is spray-dried to make a dry powder. Separately take polyethylene glycol 400 and gelatin, put them in a 40°C water bath to dissolve, add the obtained extract powder, glycerin, cholic acid, paraben, etc., and stir well, the weight ratio is 60:25:5:2:2:1 , while hot, pour it into a cooling and coated suppository mold with liquid paraffin until it slightly overflows the die opening. After cooling and solidifying, cut off the overflowing part with a knife, push out the suppository, and dry it to obtain a water-soluble medicated suppository.

Embodiment 3

[0021] Using Periplaneta americana as raw material, dry and pulverize Periplaneta americana to 100 mesh, add 12 times the weight of 75% ethanol solution, soak and extract at 60°C for 1.5h, filter, concentrate the filtrate into a clear paste with a relative density of 1.15, add Extract with 6 times the amount of water, and spray-dry the aqueous layer extract to make a dry powder. Take another polyethylene glycol 4000, polyethylene glycol 400, melt in a water bath at 40°C, add the obtained extract powder and mix, so that the drug is evenly dispersed in the matrix, the weight ratio is 40:50:5, pour it into the cooling while it is hot And coated with polyoxyethylene castor oil, linoleic acid, fatty acid glyceride and vegetable oil in the suppository mold to the extent that it slightly overflows the die mouth, after cooling and solidifying, cut out the overflowing part with a knife, push out the suppository, and dry it in the air. A water-soluble medicated suppository is obtained. ...

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PUM

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Abstract

The invention belongs to the field of pharmaceutical preparations and particularly relates to a periplaneta americana rectum drug preparation. The periplaneta americana rectum drug preparation is a rectum suppository taking various forms of periplaneta americana extracts as active ingredients. The periplaneta americana suppository provided by the invention has the effect of prolonging the drug release and action time or quickly releasing to take effects, can be used for treating ulcerative colitis-related diseases and indications, significantly relieves intestinal ulcer and inflammatory reaction and overcomes the defects of worse oral administration effect and slow effect, the drug action efficiency is improved, a better treatment mode is provided for clinical patients, and clinical medication forms of the periplaneta americana preparation are enriched.

Description

[0001] Technical field: the present invention relates to the field of pharmaceutical preparations, in particular to the preparation and application of a suppository of Periplaneta americana extract. Background technique: [0002] Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease of unknown etiology that occurs mainly in the colorectal mucosa and submucosa. It is characterized by mucosal inflammation and ulceration, and the lesions involve the colon and rectum. In my country, especially in the past two decades, its incidence rate has been increasing year by year. According to domestic epidemiological survey data, the incidence rate of UC in the south is 2.05 / 100,000, and the incidence rate in the north is 1.64 / 100,000. The main symptoms of UC are mucus, pus, bloody stools and tenesmus, accompanied by abdominal pain and diarrhea. Extraintestinal manifestations include arthritis, arthralgia, erythema nodosum, iritis, dermatitis, and oral ulcers. Severe pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61K9/02A61P1/00A61P1/04
CPCA61K9/0031A61K9/02A61K35/63A61K2236/331A61K2236/333A61K2236/39
Inventor 刘越飞胡一晨傅超美
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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