Theophylline slow-release tablet and preparation method thereof

A technology of slow-release tablets and theophylline, which is applied in the field of medicine, can solve problems such as poor release linearity, large difference in release degree of theophylline sustained-release tablets, and unfavorable therapeutic effect of theophylline, so as to solve diseases, improve use value, and avoid Toxic effects

Inactive Publication Date: 2018-03-23
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as far as the theophylline tablets currently on the market are concerned, the release of theophylline sustained-release tablets varies greatly from tablet to tablet or from batch to batch, and the release of theophylline sustained-release tablets from each batch varies greatly. , and the release linearity at different times is poor, which is not conducive to stably exerting the therapeutic effect of theophylline

Method used

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  • Theophylline slow-release tablet and preparation method thereof

Examples

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Embodiment 1

[0028] A theophylline sustained-release tablet and a preparation method thereof, consisting of a tablet core and a coating layer, calculated in parts by weight, the tablet core includes the following raw and auxiliary materials: 60 parts of theophylline, 5 parts of bellflower, 0.5 part of tangerine peel, 8 parts of licorice

[0029] 0.3 parts of almonds, 3 parts of butter; the coating layer includes the following raw materials: 10 parts of titanium dioxide, 15 parts of polyvinylpyrrolidone, 0.3 parts of beeswax, 0.6 parts of carnauba wax, and 0.6 parts of sucrose.

[0030] Among them, platycodon grandiflorum is soaked in 90% ethanol solution for 12-24 hours, rinsed with distilled water for 30 minutes, dried until the water content is lower than 8%, and crushed to a size of 500-800 mesh under the action of supersonic airflow.

[0031] A preparation method for theophylline sustained-release tablets, comprising the steps of:

[0032] (1) Superfinely pulverize tangerine peel, lico...

Embodiment 2

[0039] A theophylline sustained-release tablet and a preparation method thereof, comprising a tablet core and a coating layer, calculated in parts by weight, the tablet core includes the following raw and auxiliary materials: 80 parts of theophylline, 8 parts of bellflower, 0.8 part of tangerine peel, and 12 parts of licorice , 0.6 parts of almonds, 6 parts of lard; the coating layer includes the following raw materials: 12 parts of titanium dioxide, 35 parts of ethyl acrylate-methyl methacrylate copolymer, 0.8 parts of beeswax, 0.9 parts of carnauba wax, and 0.8 parts of sucrose.

[0040] Among them, platycodon grandiflorum is soaked in 90% ethanol solution for 12-24 hours, rinsed with distilled water for 30 minutes, dried until the water content is lower than 8%, and crushed to a size of 500-800 mesh under the action of supersonic airflow.

[0041] A preparation method for theophylline sustained-release tablets, comprising the steps of:

[0042] (1) Superfinely pulverize tan...

Embodiment 3

[0049]A theophylline sustained-release tablet and a preparation method thereof, consisting of a tablet core and a coating layer, calculated in parts by weight, the tablet core includes the following raw and auxiliary materials: 70 parts of theophylline, 6 parts of bellflower, 0.6 part of tangerine peel, 10 parts of licorice , 0.38 parts of almonds, 3 parts of mutton oil; the coating layer includes the following raw materials: 10-12 parts of titanium dioxide, 15 parts of methyl cellulose, 0.3 parts of beeswax, 0.6 parts of carnauba wax, and 0.6 parts of sucrose.

[0050] Among them, platycodon grandiflorum is soaked in 90% ethanol solution for 12-24 hours, rinsed with distilled water for 30 minutes, dried until the water content is lower than 8%, and crushed to a size of 500-800 mesh under the action of supersonic airflow.

[0051] A preparation method for theophylline sustained-release tablets, comprising the steps of:

[0052] (1) Superfinely pulverize tangerine peel, licoric...

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Abstract

The invention provides a theophylline sustained-release tablet and a preparation method thereof, which relate to the technical field of medicine and consist of a tablet core and a coating layer; the preparation method comprises the following steps: ultrafinely pulverize tangerine peel, licorice, and almonds, mix them uniformly, add Prepare suspension A with sterile water; add suspension A to the wet granulator, add animal fat to the wet granulator, stir and shear at room temperature, and process for 5-12 minutes; add tea to the wet granulator Alkali, after mixing for 50-60min, the tablet core is obtained; the polymer of titanium dioxide and polyethylene glycol, beeswax, carnauba wax, and sucrose are added to purified water to make a coating solution; the granules are dried, and the coating solution is added. Coating and drying are performed to obtain theophylline sustained-release tablets. The theophylline sustained-release tablet of the present invention can be released at a constant rate, stable in quality, safe, effective and stable to solve the ailments of asthmatic patients, avoid the toxic and side effects caused by the increased release of theophylline, and better improve the use value of theophylline sustained-release tablet , help to solve the patient's pain.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a theophylline sustained-release tablet and a preparation method thereof. Background technique [0002] Theophylline is a methylpurine drug. It has the effects of strengthening the heart, diuresis, expanding coronary arteries, relaxing bronchial smooth muscle and stimulating the central nervous system. Mainly used for the treatment of bronchial asthma, emphysema, bronchitis, cardiac dyspnea. [0003] Bronchial asthma (abbreviation: asthma) is a kind of common disease, frequently-occurring disease. At present, there are about 300 million asthmatics in the world, and about 30 million asthmatics in China. The onset of asthma is characterized by attacks within minutes and hours to days. Due to the long attack time of asthma, irregularity, instability and predictability, common preparations cannot immediately solve the patient's pain and bring pain to the patient. Asthma is an im...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/28A61K31/522A61K36/752A61K47/02A61K47/44A61K47/10A61K47/26A61K47/32A61P11/06A61K35/35
CPCA61K31/522A61K9/2813A61K9/282A61K9/2826A61K9/284A61K9/2853A61K35/35A61K36/346A61K36/484A61K36/736A61K36/752A61K2300/00
Inventor 操铖高煜
Owner HUAYI PHARMA ANHUI CO LTD
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