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Narcotine tablet and preparation method thereof

A technology of noscapine tablets and microcrystalline cellulose, which is applied in the field of medicine, can solve the problems of affecting the therapeutic effect of narcotin, accelerating the dissolution rate of drugs, and the large proportion of excipients, so as to achieve stable and effective blood drug concentration and disintegration time Short, long-lasting effects

Inactive Publication Date: 2018-02-06
广州市桐晖药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disintegration time of narcotin tablets on the market is long, the absorption is poor, the bioavailability is low, and the proportion of excipients is large. Children, the elderly, bedridden patients and patients with dysphagia are inconvenient to take medicine and have poor compliance, which affects the treatment of narcotin. In order to solve the above problems, the present invention provides a Norcidine tablet and a preparation method thereof to accelerate the dissolution rate of the drug

Method used

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  • Narcotine tablet and preparation method thereof
  • Narcotine tablet and preparation method thereof
  • Narcotine tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Preparation method of Noscapine Tablets

[0024] (1) Weigh 100g of narcotin, 10g of chitin, 15g of microcrystalline cellulose, 5g of low-substituted hydroxypropyl cellulose, 5g of lactose, and 5g of calcium sulfate into 10g of water, stir and mix evenly, and the microcrystalline cellulose The particle size is 0.1 μm, the crystallinity of microcrystalline cellulose is 70%, and the hydroxypropyl group in low-substituted hydroxypropyl cellulose is 10%. It is granulated with a 20-mesh sieve, and the wet granules are placed in a drying oven. 50 ℃, air blowing, 20 mesh sieve granulation;

[0025] (2) Use special-shaped punching tablets.

[0026] 2. Take narcotin tablets, and measure the disintegration time according to the 2015 edition of "Pharmacopoeia of the People's Republic of China".

[0027] 3. Dissolution test: Take Narcodine Tablets, operate according to the dissolution test method of "Pharmacopoeia of the People's Republic of China" in 2015, with 0.01mol L conta...

Embodiment 2

[0030] 1. Preparation method of Noscapine Tablets

[0031] (1) Weigh 150g of narcotin, 15g of chitin, 18g of microcrystalline cellulose, 6g of low-substituted hydroxypropyl cellulose, 6g of lactose, and 6g of calcium sulfate into 15g of water, stir and mix evenly, and the microcrystalline cellulose The particle size is 0.5 μm, the crystallinity of microcrystalline cellulose is 75%, and the hydroxypropyl group in low-substituted hydroxypropyl cellulose is 12%. It is granulated with a 20-mesh sieve, and the wet granules are placed in a drying oven. 50 ℃, air blowing, 20 mesh sieve granulation;

[0032] (2) Use special-shaped punching tablets.

[0033] 2. Take narcotin tablets, and measure the disintegration time according to the 2015 edition of "Pharmacopoeia of the People's Republic of China".

[0034] 3. Dissolution test: Take Narcodine Tablets, operate according to the dissolution test method of "Pharmacopoeia of the People's Republic of China" in 2015, with 0.01mol L conta...

Embodiment 3

[0037] 1. Preparation method of Noscapine Tablets

[0038] (1) Weigh 160g of narcotin, 16g of chitosan, 20g of microcrystalline cellulose, 8g of low-substituted hydroxypropyl cellulose, 10g of lactose, and 10g of calcium sulfate into 20g of water, stir and mix evenly, and the microcrystalline cellulose The particle size is 1 μm, the crystallinity of microcrystalline cellulose is 80%, and the hydroxypropyl group in low-substituted hydroxypropyl cellulose is 13%. It is granulated with a 20-mesh sieve, and the wet granules are placed in a drying oven at a drying temperature of 50 ℃, air blast, 20-mesh sieve for granulation;

[0039] (2) Use special-shaped punching tablets.

[0040] 2. Take narcotin tablets, and measure the disintegration time according to the 2015 edition of "Pharmacopoeia of the People's Republic of China".

[0041] 3. Dissolution test: Take Narcodine Tablets, operate according to the dissolution test method of "Pharmacopoeia of the People's Republic of China"...

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Abstract

The invention relates to the field of medicines and specifically relates to a narcotine tablet and a preparation method thereof. The narcotine tablet is prepared from narcotine, deacetylated chitin, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, lactose, calcium sulfate and water. The narcotine tablet provided by the invention has the characteristics of quick effectiveness ina human body, long-lasting pharmacological effect and stability, is capable of reducing the side effect and has the characteristics of high safety, long treatment time, quick orally-taken absorption,and the like. The invention also provides the preparation method for the narcotine tablet. The production technology is more stable, controllable and easy for industrialization.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a Noscapine tablet and a preparation method thereof. Background technique [0002] With the increasing air pollution, the incidence of smog is also increasing. Dirty air does great harm to the human respiratory system. According to the statistics of the national health department, nearly 300 million people in my country are infected with respiratory diseases every year, and among them, there are as many as 50 million cough patients. Every winter, the air is cold, the smog is more serious, and the number of coughing patients further increases. Patients with chronic cough are also prone to complications such as high blood pressure, cerebral hypoxia, and pulmonary heart disease. [0003] Narcidine is odorless, almost insoluble in water, and is an antitussive used to treat dry coughs. However, the disintegration time of Narcodine tablets on the market is long, the absorption is poor, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4741A61K47/36A61K47/38A61K47/26A61K47/02A61P11/14
CPCA61K9/2054A61K9/2009A61K9/2018A61K9/205A61K9/2095A61K31/4741
Inventor 张彤丽
Owner 广州市桐晖药业有限公司
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