Nitroglycerin tablets and preparation method thereof

Abstract

The invention relates to a glonoin tablet which is a drug for treating angina and a method for preparing the same. The glonoin tablet contains 0.5 milligram of glonoin and a proper amount of pharmaceutic adjuvants which are selected from a bulking agent, a stabilizing agent, a bonding agent, a disintegrating agent and a lubricating agent. In the prescription, the valuing ranges of all components for preparing one thousand tablets are that: 5.0 milliliter of 10 percent glonoin solution, 1 to 15 grams of microcrystalline cellulose, 0.1 to 1.0 gram of polyvinyl pyrrolidon, 10 to 30 grams of lactose, 1.0 to 4.0 grams of cross-linking polyvidone, 0.1 to 0.4 gram of magnesium stearate, and 10 to 20 gram of 65 percent ethanol; and the raw materials and the pharmaceutic adjuvants are screened, mixed, granulated and tableted to prepare the glonoin tablet. In the glonoin tablet, the stabilizing agent is added in the prescription, thereby lowering the vapor pressure for volatilizing the glonoin, shortening disintegration time, improving stabilization and prolonging period of validity.

Description

technical field [0001] The invention relates to a nitroglycerin tablet for treating angina pectoris and a preparation method thereof. Background technique [0002] Angina pectoris is a common symptom of coronary atherosclerotic heart disease (abbreviated as coronary heart disease), which is a clinical syndrome caused by coronary insufficiency, myocardial acute and temporary ischemia and hypoxia. Paroxysmal colic or dull pain occurs at the back of the sternum and the front of the heart during the attack, and can radiate to the left upper limb. The pain is caused by the metabolites of ischemia and hypoxia, lactic acid, pyruvic acid, or similar skin-stimulating skin substances. caused by etc. [0003] Nitroglycerin is the first discovered drug for treating angina pectoris, and it is a representative drug of nitrates. It has been used for more than 100 years in the treatment of angina pectoris. It is still one of the drugs of choice for the prevention and treatment of angina p...

AI Technical Summary

Problems solved by technology

However, because nitroglycerin has a high vapor pressure and strong volatility, it is easily affected by factors such as temperature, humidity, and packaging, and it is easy to volatilize during storage, so nitroglycerin tablets are quite unstable.

According to clinical statistics, there are certain differences in the efficacy of nitroglycerin tablets produced by different manufacturers at home and abroad, the disintegration time is long, and the storage period is also of different lengths, which greatly reduces the safety of clinical medication.

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