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Neem oil nanometer composition, and preparation method and applications thereof

A nano-composite, neem technology, applied in the directions of drug combination, pharmaceutical formula, cosmetic preparation, etc., can solve the problems of low bioavailability, easy oxidative deterioration, difficult to disperse, etc., and achieve high bioavailability , The effect of less skin irritation and large drug loading

Inactive Publication Date: 2017-12-15
WUHAN BEST CARRIER NANO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Neem oil is mainly composed of oleic acid, palmitic acid, stearic acid, linoleic acid, etc. It has the disadvantages of easy oxidation and deterioration, poor stability, and difficulty in dispersing in water, resulting in low bioavailability and difficult to add directly To cosmetics, health products, medicines

Method used

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  • Neem oil nanometer composition, and preparation method and applications thereof
  • Neem oil nanometer composition, and preparation method and applications thereof
  • Neem oil nanometer composition, and preparation method and applications thereof

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preparation example Construction

[0031] The present invention also provides the preparation method of the neem oil nano composition described in the above technical scheme, comprising the following steps:

[0032] Mix emulsifiers, co-emulsifiers, polyols, antioxidants and preservatives to obtain a primary mix;

[0033] The primary mixture is mixed with the neem oil to obtain the neem oil nano composition.

[0034] The invention mixes the emulsifier, co-emulsifier, polyhydric alcohol, antioxidant and preservative to obtain primary mixture. The present invention does not have any special limitation on the order of adding the emulsifier, co-emulsifier, polyol, antioxidant and preservative, and the order of addition well known to those skilled in the art can be adopted. In the present invention, it is preferred to add the emulsifying agent one by one additives, co-emulsifiers, polyols, antioxidants and preservatives. In the present invention, there is no special limitation on the specific mixing method, and a m...

Embodiment 1

[0041] 5% Tween 80, 15% polyoxyethylene castor oil ether-40, 3% polyethylene glycol 400 monostearate, 2% ceteareth-25, 20% propylene glycol, 40% 1 ,3-Butanediol, 5% 1,2-Pentanediol, 5% Diethylene Glycol Monoethyl Ether, 1% Butylene Glycol-9, 1% Vitamin C Ethyl Ether, 1% Vitamin E Acetate Esters and 1% phenoxyethanol were stirred at a speed of 200rpm for 10min in a water bath at 45°C. After mixing evenly, 1% neem oil was added, and the stirring was continued for 20min to make the whole system uniform and transparent. After cooling to room temperature, bitter Neem Oil Nanocomposition.

[0042] Detecting the particle size of the neem oil nano composition, the particle size of the neem oil nano composition can be obtained as 149.9nm.

Embodiment 2

[0044] 20% Tween 20, 12% PEG30 hydrogenated castor oil, 3% ceteareth-20, 29.5% glycerin, 20% 1,3-butanediol, 7% sorbitol, 2% butanol Ether-35, 1% vitamin E, and 0.5% imidazolidinyl urea were stirred at a speed of 400 rpm for 15 minutes in a water bath at 50°C. After mixing evenly, 5% neem oil was added, and the stirring was continued for 30 minutes to make the whole system uniform and transparent , after cooling to room temperature, the neem oil nano composition was obtained.

[0045] Detecting the particle size of the neem oil nano composition, the particle size of the neem oil nano composition can be obtained as 121.6nm.

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Abstract

The invention provides a neem oil nanometer composition, and belongs to the field of cosmetic. The neem oil nanometer composition comprises, by weight, 1.0 to 30.0% of neem oil, 25.0 to 75.0% of an emulsifier, 0.8 to 17.0% of a co-emulsifier, 1.0 to 65.0% of a polyhydric alcohol, 0.01 to 2.0% of an anti-oxidant, and 0.01 to 4.0% of an antiseptic. According to a preparation method, a homogeneous disperse system with thermodynamic stability is formed by neem oil, the emulsifier, the co-emulsifier, and the polyhydric alcohol, water solubility is high, stability is high, no floating oil is generated, no aggregation is caused, and excellent mosquito repelling, bacteria inhibiting, inflammation relieving, and pain eliminating effects are achieved. The neem oil nanometer composition is high in drug loading capacity, is capable of entering skin deep tissue through skin stratum corneum, releasing neem oil continuously, and achieving excellent mosquito repelling, bacteria inhibiting, inflammation relieving, and pain eliminating effects.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a nano composition of neem oil and its preparation method and application. Background technique [0002] Neem is a tall tree commonly found in tropical rain forests. It can grow up to 40 meters high. The tree produces a brown square nut similar to a chestnut, about 3 to 4 inches wide. Neem oil, extracted from the kernel of this nut, has anti-inflammatory, antibacterial, anti-rheumatitis, anti-mosquito effects. [0003] Neem oil is mainly composed of oleic acid, palmitic acid, stearic acid, linoleic acid, etc. It has the disadvantages of easy oxidation and deterioration, poor stability, and difficulty in dispersing in water, resulting in low bioavailability and difficult to add directly To cosmetics, health products, medicines. Therefore, how to improve the solubility and storage stability of neem oil in aqueous medium has become a key technical problem in its production and use. Cont...

Claims

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Application Information

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IPC IPC(8): A61K8/92A61K8/34A61K8/06A61Q17/00A61Q17/02A61P29/00
CPCA61K8/922A61K8/068A61K8/345A61K2800/413A61K2800/72A61Q17/005A61Q17/02
Inventor 刘卫石丛姣许琦闻庆陈家铃杨达峰
Owner WUHAN BEST CARRIER NANO TECH
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