Tofacitinib tablets and preparation method thereof
A technology for tofacitinib and nigra tablets, which is applied in the field of tofacitinib tablets and their preparation, and achieves the effects of good stability, convenient medication and improved medication compliance.
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Embodiment 1
[0018] 5 parts of tofacitinib citrate, 75 parts of mannitol, and 10 parts of hydroxypropylmethylcellulose acetate succinate were passed through a 100-mesh sieve, and after mixing evenly, they were placed in a fluidized bed granulator, and Top spray operation mode, wet granulation. The obtained granules were dried under reduced pressure at 40°C, and then passed through a 60-mesh sieve for granulation. The above granules are mixed with 1 part of croscarmellose sodium, 3 parts of aspartame and 2 parts of magnesium stearate, and then compressed into tablets to obtain the preparation.
Embodiment 2
[0020] 10 parts of tofacitinib citrate, 50 parts of lactose, and 25 parts of methacrylic acid copolymer S were passed through a 100-mesh sieve, mixed evenly, and placed in a wet granulator for wet granulation. The obtained granules were dried under reduced pressure at 40°C, and then passed through a 60-mesh sieve for granulation. The above-mentioned granules are mixed with 10 parts of crospovidone, 3 parts of aspartame and 2 parts of magnesium stearate, and then compressed into tablets to prepare.
Embodiment 3
[0022] 10 parts of tofacitinib citrate, 55 parts of lactose, 20 parts of mannitol, and 5 parts of ethyl cellulose were passed through a 100-mesh sieve, mixed evenly, and then granulated by a dry granulator. The resulting granules are sieved through a 60-mesh sieve. The above-mentioned granules are mixed with 5 parts of croscarmellose sodium, 1 part of aspartame and 4 parts of magnesium stearate, and then compressed into tablets to prepare.
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