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A fluorescent wide chromaticity test paper for visual detection of copper ions and its preparation method and application

A copper ion and fluorescence technology, applied in the field of copper ion detection, can solve the problems of insensitive dose chromaticity change of target object, inability to visualize quantitative detection of target object, narrow spectral evolution range, etc., to widen the application range and avoid other impurities. The effect of interference and high sensitivity

Active Publication Date: 2020-01-17
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In general, the existing fluorescent test papers generally have problems such as insensitivity to changes in target dose and chromaticity, narrow spectral evolution range, and inability to perform visual and quantitative detection of targets. Fluorescent test paper that can perform visual and quantitative detection of targets still relatively rare

Method used

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  • A fluorescent wide chromaticity test paper for visual detection of copper ions and its preparation method and application
  • A fluorescent wide chromaticity test paper for visual detection of copper ions and its preparation method and application
  • A fluorescent wide chromaticity test paper for visual detection of copper ions and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Preparation of Quantum Dots

[0027] 0.2284g cadmium chloride (CdCl 2 2.5H 2 O) join in 100mL deoxygenated ultrapure water, then add 0.21mL3-mercaptopropionic acid (MPA), then adjust its pH value to 10 with 1M sodium hydroxide solution to obtain a mixed solution; get 0.0319g tellurium powder and Add 0.05g of sodium borohydride to 2mL of ultrapure water, under the protection of nitrogen, ice bath for 8 hours, and react to form sodium telluride hydride; inject 10mL of 0.5M sulfuric acid solution into the resulting sodium telluride h 2Put all the Te into the above-mentioned mixed solution, stir at room temperature for 20 minutes, the color of the mixed solution changes from colorless to orange-yellow, and continue to heat and reflux at 100°C for 50 minutes to obtain a green telluride modified with mercaptopropionic acid. Cadmium quantum dots, if you want to get red quantum dots, you need to heat and reflux for 24-48 hours. The obtained quantum dot stock solution is i...

Embodiment 2

[0035] 1. Preparation of Quantum Dots

[0036] The preparation method of quantum dots in this embodiment is the same as that in Embodiment 1.

[0037] 2. Preparation of Carbon Dots

[0038] The method for preparing carbon dots in this example is the same as in Example 1.

[0039] 3. Preparation of three-color ratiometric fluorescent probes

[0040] The preparation method of the three-color ratiometric fluorescent probe in this example is the same as that in Example 1.

[0041] 4. Prepare standard stock solutions of 0.3mM copper ions and 3mM other ions respectively.

[0042] 5. Add a certain volume of the different ion standard stock solutions in step 4 to the solution of the three-color ratiometric fluorescent probe.

[0043] 6. Detect the selectivity of the test paper to other ions such as image 3 shown.

Embodiment 3

[0045] 1. Preparation of Quantum Dots

[0046] The preparation method of quantum dots in this embodiment is the same as that in Embodiment 1.

[0047] 2. Preparation of Carbon Dots

[0048] The method for preparing carbon dots in this example is the same as in Example 1.

[0049] 3. Preparation of three-color ratiometric fluorescent probes

[0050] The preparation method of the three-color ratiometric fluorescent probe in this example is the same as that in Example 1.

[0051] 4. Preparation of test strips

[0052] The purchased commercial printer ink cartridges were washed with deionized water and dried to obtain blank ink cartridges. The three-color ratio probe is injected into the blank cartridge with a syringe, and a 7×3cm print is printed on ordinary filter paper 2 The rectangular pattern, repeat printing about 30 times, let it stand naturally for 5 minutes, and cut the rectangular pattern into 3×1cm 2 In the strip shape, the detection test paper that responds to th...

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Abstract

The invention discloses fluorescent wide chroma test paper for visually detecting copper ions as well as a preparation method and application of the test paper. The preparation method comprises the following steps: by taking a three-color ratio fluorescence probe as ink and taking filter paper as a solid-phase carrier through an inkjet printer, uniformly printing, thereby obtaining the test paper capable of visually detecting the copper ions, wherein the three-color ratio fluorescence probe refers to blue carbon dots, green quantum dots and red quantum dots, and the quantum dots are all modified by 3-mercaptopropionic acid. The three-color ratio fluorescence test paper is constructed to be used for visually detecting the copper ions by utilizing double-quenching principle first, the prepared detection test paper has the advantage that the color change range is wide compared with the conventional double-ratio fluorescence test paper, and along with addition of the detection object, test paper colors can be obviously identified by naked eyes from light scarlet, light flesh color, deep orange, grass green, dark olive green, slate blue, royalblue to cyanic color (Figure 4).

Description

technical field [0001] The invention belongs to the technical field of copper ion detection, and in particular relates to a fluorescent wide chromaticity test paper for visual detection of copper ions and a preparation method and application thereof. Background technique [0002] Copper is an essential element for human health, and enzymes exploit the metal's redox activity for energy generation, neurotransmitter and pigment synthesis, and epigenetic modification. On the one hand, copper deficiency can lead to many diseases such as anemia, pancytopenia and bone marrow abnormalities. On the other hand, abnormalities in copper metabolism are also associated with many diseases, including cancer, neurodegenerative Alzheimer's disease, Parkinson's and Huntington's diseases, and genetic disorders such as curly hair syndrome and Wilson's disease. As a typical copper-mediated disease, Wilson's disease is an autosomal recessive disorder of copper accumulation in tissues. Patients w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64
CPCG01N21/643G01N2021/6432G01N2021/6439
Inventor 都述虎蔡月青尤军辉张丽颖
Owner NANJING MEDICAL UNIV
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