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A method and application of three-dimensionally printed bioceramic scaffolds based on photocuring

A photocuring molding, bioceramic technology, applied in applications, ceramic products, tissue regeneration, etc., can solve the problems of low strength of bioceramic scaffolds, poor sintering performance of bioceramics, etc. Effects of Bone and Vascularization

Active Publication Date: 2020-09-22
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

By introducing low melting point bioglass as a sintering aid, this method can solve the problem of low strength of bioceramic scaffold caused by excessive organic additives and poor sintering performance of bioceramic. High-precision hole structure, and the three-dimensional size (especially the Z-axis) is not limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation method of embodiment 1β-tricalcium phosphate ceramic support

[0029] 1. Configure the photosensitive resin premix, the prepolymer used is urethane acrylate, the initiator is benzoyl peroxide, and the diluent is propoxylated neopentyl glycol acrylate. β-tricalcium phosphate and Sr-containing low-melting bioglass sintering aid (50P 2 o 5 -20Na 2 (O-30SrO) powder and the photosensitive resin premix are evenly mixed to obtain a photosensitive ceramic slurry with a solid phase content of 50%. The content of β-tricalcium phosphate in the ceramic slurry is 30%, and the content of the glass firing aid is 20%.

[0030] 2. Input the three-dimensional model of the porous bracket into the photocuring molding machine; place the photosensitive ceramic slurry in step (1) on the DLP photocuring molding equipment, and the projection method is top-down, and the three-dimensional printing is performed by the photocuring molding method. Porous β-tricalcium phosphate ce...

Embodiment 2

[0033] The preparation method of embodiment 2 calcium carbonate ceramic support

[0034] 1. Configure the photosensitive resin premix, the prepolymer used is polyurethane acrylate, the initiator is benzoin (BE), and the diluent is propoxylated neopentyl glycol acrylate. Calcite-type calcium carbonate and Sr-containing bioglass sintering aid (50P 2 o 5 -20Na 2(O-20CaO-10SrO) powder and the photosensitive resin premix are evenly mixed to obtain a photosensitive ceramic slurry with a solid phase content of 60%. The content of calcium carbonate in the ceramic slurry is 30%, and the content of glass sintering aid is 30%.

[0035] 2. Input the three-dimensional model of the porous bracket into the photocuring molding machine; place the above-mentioned photosensitive ceramic slurry on the DLP photocuring molding equipment, and the projection method is bottom-up, and the designed porous structure is three-dimensionally printed by the photocuring molding method Calcium carbonate ce...

Embodiment 3

[0038] The preparation method of embodiment 3 calcium silicate ceramic support

[0039] 1. Configure the photosensitive resin premix, the prepolymer used is epoxy acrylate, the initiator is benzoin (BE), and the diluent is tricyclodecane dimethanol diacrylate. Calcium silicate and B, Si bioglass glass sintering aid (45SiO 2 -29CaO-15Na 2 O-4P 2 o 5 -7B 2 o 3 ) powder is evenly mixed with the photosensitive resin premix to obtain a photosensitive ceramic slurry with a solid phase content of 55%. The content of calcium silicate in the ceramic slurry is 35%, and the content of glass sintering aid is 20%.

[0040] 2. Input the three-dimensional model of the porous support into the photocuring molding machine; place the above-mentioned photosensitive ceramic slurry on the DLP photocuring molding equipment, and the projection method is bottom-up, and the designed porous carbonic acid is three-dimensionally printed by the photocuring molding method. Calcium ceramic stent body....

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Abstract

The invention discloses a method for performing three-dimensional printing on a biological ceramic bracket based on light-cured molding. The method comprises the following steps: firstly, mixing biological ceramic, a biological glass sintering aid and resin premixed liquid uniformly to obtain photosensitive ceramic slurry; putting the photosensitive ceramic slurry on light-cured molding equipment, and performing three-dimensional printing on a biological ceramic bracket green body according to a three-dimensional model which is input into a forming machine; drying, degreasing and sintering the biological bracket green body to obtain the biological ceramic bracket. The biological ceramic bracket has the following characteristics: the three-dimensional size is not limited, the strength is high, 100 percent of three-dimensional holes are communicated, and the hole structure is accurately controllable, and the application prospect in the field of a bone defect repairing material is good.

Description

technical field [0001] The invention belongs to the technical field of biomanufacturing or biomedical materials, and more specifically relates to a method and application of a three-dimensionally printed bioceramic scaffold based on photocuring molding. Background technique [0002] Degradable bioceramics are the most common synthetic bone repair materials. Degradable bioceramic materials mainly include silicate ceramics, calcium phosphate ceramics and calcium carbonate ceramics. Degradable bioceramics are often made into porous scaffolds to provide space for the growth of bone tissue and cells, to achieve structural osteoconduction, and to promote the degradation and absorption of materials, thereby accelerating bone reconstruction and regeneration. At present, the molding and preparation methods of porous bioceramics mainly include pore-forming agent method, freezing casting method, gas foaming method, organic foam impregnation method, etc. Porous bioceramic scaffolds pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/10A61L27/12A61L27/54A61L27/50B33Y10/00B33Y70/10B33Y80/00C04B35/01C04B35/195C04B35/22C04B35/447C04B35/622C04B38/06
CPCA61L27/10A61L27/12A61L27/50A61L27/54A61L27/56A61L2300/412A61L2430/02B33Y10/00B33Y70/00B33Y80/00C04B35/01C04B35/195C04B35/22C04B35/447C04B35/622C04B38/067C04B2235/3212C04B2235/36C04B2235/365C04B2235/442C04B2235/6562C04B2235/6567C04B2235/658C04B2235/96C04B38/0051C04B38/0074
Inventor 何福坡任伟玮潘东伟伍尚华
Owner GUANGDONG UNIV OF TECH
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