Magnesium-copper coating for bone implant and preparation method thereof

A technology of copper coating and bone implantation, which is applied in the direction of coating, metal material coating process, ion implantation plating, etc., can solve the problems of bone compatibility infection of implant materials, achieve good biocompatibility, Effect of reducing infection and increasing success rate

Active Publication Date: 2019-11-29
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the problems of osseointegration and infection of implant materials, the present invention provides a magnesium-copper coating for bone implants and a preparation method thereof, using chemical vapor deposition technology and vapor deposition technology, on titanium and titanium alloys, cobalt-based Metal magnesium-copper coatings are prepared on alloys, stainless steel, polymer materials or mesh glassy carbon to solve the problems of osteocompatibility and infection of existing implant materials. The permanent implant materials obtained by this method are suitable for mechanical properties of various implant sites Requirements, and has excellent biocompatibility, and has a bactericidal function

Method used

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  • Magnesium-copper coating for bone implant and preparation method thereof
  • Magnesium-copper coating for bone implant and preparation method thereof
  • Magnesium-copper coating for bone implant and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0031] Put the porous titanium alloy (Ti-6Al-4V) sample into the furnace body 1 of the deposition chamber; put the copper chloride powder into the furnace body 2 of the evaporation chamber, and put pure magnesium into the high temperature zone of the furnace body 1 of the deposition chamber, and the atomic ratio is Magnesium: copper chloride = 25:1, then connect the air circuit, check the sealing condition, and draw a limit vacuum (10 -4 Pa), the whole system was repeatedly purged 3 times with argon to ensure that the oxygen content was minimized. Set the deposition temperature to 300°C, the copper chloride source evaporation temperature to 200°C, the working vacuum to 5Pa, the hydrogen flow to 50SCCM, the deposition time to 3h, the thickness of the deposited metal magnesium-copper layer to be 200μm, and the mass percentage of copper to be 2%. To determine the cytocompatibility of the coating, ALP staining was performed and the results were as follows image 3 As shown, after...

Embodiment 2

[0033] Put the porous titanium alloy (Ti-6Al-4V) sample into the furnace body 1 of the deposition chamber; put the copper chloride powder into the furnace body 2 of the evaporation chamber, and put pure magnesium into the high temperature zone of the furnace body 1 of the deposition chamber, and the atomic ratio is Magnesium: copper chloride = 20:1, then connect the air circuit, check the sealing condition, and draw a limit vacuum (10 -4 Pa), the whole system was repeatedly purged 3 times with argon to ensure that the oxygen content was minimized. Set the deposition temperature to 200°C, the copper chloride source evaporation temperature to 300°C, the working vacuum to 5Pa, the hydrogen flow rate to 100SCCM, the deposition time to 2h, the thickness of the deposited metal magnesium-copper layer to be 100μm, and the mass percentage of copper to be 5%. X-ray diffraction pattern as Figure 4 As shown, due to the relatively low copper content, only the diffraction information of m...

Embodiment 3

[0035] Put the porous titanium alloy (Ti-6Al-4V) sample into the furnace body 1 of the deposition chamber; put the copper chloride powder into the furnace body 2 of the evaporation chamber, and put pure magnesium into the high temperature zone of the furnace body 1 of the deposition chamber, and the atomic ratio is Magnesium: copper chloride = 15:1, then connect the air circuit, check the sealing condition, and draw a limit vacuum (10 -4Pa), the whole system was repeatedly purged 3 times with argon to ensure that the oxygen content was minimized. Set the deposition temperature to 150°C, the evaporation temperature of the copper chloride source to 300°C, the working vacuum to 50Pa, the flow rate of hydrogen to 100SCCM, the deposition time to 1.5h, the thickness of the deposited metal magnesium-copper layer to be 150μm, and the mass percentage of copper to be 7%.

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Abstract

In order to solve the osseointegration and infection problems of implant materials, the invention provides a magnesium-copper coating for bone implantation and a preparation method thereof. Chemical vapor deposition technology and vapor plating technology are employed to prepare a metal magnesium-copper coating on titanium and titanium alloy, cobalt based alloy, stainless steel, polymer material or reticulated vitreous carbon, the thickness of the coating is 0.1-200 micrometers, and the mass ratio of copper element in the coating is greater than 0% and smaller than or equal to 10%. The coating and the method provided by the invention can solve the problems of bone compatibility and infection in existing implant materials, and a permanent implant material prepared by the method is suitable for the mechanical property requirements of various implantation positions, has excellent biocompatibility, and also has sterilization function.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to dental implants, joint replacements and filling materials for human tissue defects and the field of implant material antibacterial technology; specifically, the magnesium-copper coating material on the surface of implants and its preparation method . Background technique [0002] Implants such as artificial joints only have a lifespan of 10-15 years due to adverse cell reactions caused by implant loosening and abrasion, which cannot meet the long-term use requirements. Meanwhile, infection remains one of the disastrous postoperative complications of orthopedic implants. Metallic foreign bodies implanted in the body are risk factors for such infections, and a series of in vivo reactions, including the weakening of macrophage function and the passivation of the local immune system, create favorable conditions for the proliferation of pathogens. In addition, the proteins adsorbed ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C14/16C23C14/18C23C14/24C23C16/14A61L27/30A61L27/54A61L27/56A61L27/58
CPCA61L27/306A61L27/54A61L27/56A61L27/58A61L2300/102A61L2300/404A61L2300/604A61L2420/06C23C14/16C23C14/18C23C14/24C23C16/14
Inventor 于晓明刘宗元谭丽丽万鹏杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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