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Method for synchronously realizing preparation of organic microgel and packaging of material

An encapsulation material and microgel technology, which is applied in the fields of crossover of materials, medicine, and chemical industry, can solve the problems of long reaction time, inability to guarantee product stability, complicated operation, etc., and achieves short reaction time, improved stability, Manipulate controllable effects

Inactive Publication Date: 2017-08-29
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the disadvantages of complex operation, long reaction time, and inability to guarantee the stability of the product and the quality of the target material in the method of preparing organic microgel and encapsulating the target material in the prior art, the present invention proposes a method for synchronously realizing organic microgel The method for preparing and encapsulating materials and the organic microgel obtained by the method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Disperse N-benzyloxycarbonyl-L-valine n-octadecylamine (50 mg) and coumarin-6 (20 μg) in cyclohexane (10 mL), and disperse human serum albumin (500 mg) in de In ionized water (10mL); take the water phase containing human serum albumin and the oil phase containing N-benzyloxycarbonyl-L-valine n-octadecylamine and coumarin-6 at a volume ratio of 3:1 , and then put it in a water bath (50°C); put the ultrasonic probe on the oil / water two-phase interface, and perform high-intensity ultrasonic radiation (200W / cm 2 , 10min); after the reaction, the reaction solution was cooled (5°C), centrifuged (2000rpm), and the lower precipitate was washed (3 times), and finally the human serum albumin cross-linked membrane was obtained, and the fragrance-loaded Soybean-6 amino acid organogel as the core microstructural material. Under an optical microscope, the organic microgel is spherical or ellipsoidal; the average particle size of the organic microgel is measured by a laser particle s...

Embodiment 2

[0026] 12-hydroxystearic acid (100mg) and coumarin-6 (20μg) were dispersed in soybean oil (10mL), and bovine serum albumin (500mg) was dispersed in deionized water (10mL); by volume ratio 3: 1 Measure the water phase containing bovine serum albumin and the oil phase containing 12-hydroxystearic acid and coumarin-6, and then place them in a water bath (50°C); place the ultrasonic probe in the oil / water two-phase Interface, high-intensity ultrasonic radiation (200W / cm 2 , 10min); after the reaction, the reaction solution was cooled (5°C), centrifuged (2000rpm), and the lower precipitate was washed (3 times), and finally the bovine serum albumin cross-linked membrane was obtained as the shell, loaded with fragrance Soybein-6 fatty acid organogel as the core microstructural material. Under an optical microscope, the organic microgel is spherical or ellipsoidal; the average particle size of the organic microgel is measured by a laser particle size analyzer to be about 2.0 μm; The...

Embodiment 3

[0028] Magnetic γ-Fe modified with 12-hydroxystearic acid (100mg) and oleic acid 2 o 3Nanoparticles (50mg) were dispersed in soybean oil (10mL), bovine serum albumin (500mg) was dispersed in deionized water (100mL); 12-Hydroxystearic Acid and Magnetic γ-Fe 2 o 3 The oil phase of nanoparticles is then placed in a water bath (50°C); the ultrasonic probe is placed at the oil / water two-phase interface, and high-intensity ultrasonic radiation (200W / cm 2 , 10min); after the reaction, the reaction solution was cooled (10°C), centrifuged (1000rpm), and the lower precipitate was washed (4 times), and finally a bovine serum albumin crosslinked membrane was obtained, which was loaded with magnetic γ-Fe 2 o 3 Nanoparticles of fatty acid-based organogels are the core microstructural materials. Under the optical microscope, the organic microgel is spherical or ellipsoidal; the average particle size of the organic microgel is about 2.5 μm measured by a laser particle size analyzer; the...

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Abstract

The invention discloses a method for synchronously realizing preparation of an organic microgel and packaging of a material. The organic microgel prepared in the invention is a micro-structure material with a cross-linking membrane formed by a multi-mercapto surfactant as a shell and a gel-state oil phase loaded with a hydrophobic material as a core. The preparation method for the organic microgel comprises a step of carrying out high-intensity ultrasonic radiation on the oil phase containing a micromolecular organic gelling agent and the hydrophobic material and on a water phase containing the multi-mercapto surfactant, so preparation of the organic microgel and packaging of the hydrophobic material are realized synchronously. The method provided by the invention is rapid, simple, highly efficient and environment-friendly; raw materials are widely available; and the method has strong packaging capability and can be used for loading of a plurality of hydrophobic materials. Moreover, the mercapto cross-linked structure of the shell of the organic microgel and the temperature-control phase-change structure of the core of the organic microgel can improve the stability of the packaged material, and thus, the application value of the organic microgel as a material carrier is further improved.

Description

technical field [0001] The invention belongs to the intersecting fields of chemical industry, medicine and materials, and specifically relates to a method for synchronously realizing the preparation of organic microgel and encapsulating materials. Background technique [0002] Microstructured materials have been a frontier and hotspot of scientific research in recent decades due to their huge loading capacity, variable modifiability and wide application fields (medicine, biology, food, chemical industry, etc.). So far, various microstructure materials (polymers, micelles, liposomes, microcapsules, microgels, microemulsions, nanoparticles, etc.) have been developed and utilized. [0003] Among them, organic microgel is a microstructure dispersion system with hydrophobic properties formed by organic gelling agents (organic molecules or colloidal particles) interconnecting under certain conditions. Compared with other microstructure materials, organic microgels not only have m...

Claims

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Application Information

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IPC IPC(8): B01J13/00A61K47/42A61K9/06A61K31/337A61P35/00
CPCB01J13/0065A61K9/06A61K31/337A61K47/42
Inventor 李占锋王宗花杜晓玉林春明龚世达周瑜
Owner QINGDAO UNIV
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