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Method for compounding active ingredients in rhizoma acori graminei by utilizing oligopeptide supramolecular hydrogel

A technology of supramolecular hydrogel and active ingredients, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, ether/acetal active ingredients, etc., which can solve the problems of stimulus response and achieve Good digestion, reduced cytotoxicity, simple preparation

Inactive Publication Date: 2017-08-18
苏州天茹生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Fmoc-short peptide hydrogels generally have dual responses of heat response and pH response, but it is difficult for them to have other stimuli responses, such as electrochemical response, redox response, light response, etc.

Method used

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  • Method for compounding active ingredients in rhizoma acori graminei by utilizing oligopeptide supramolecular hydrogel
  • Method for compounding active ingredients in rhizoma acori graminei by utilizing oligopeptide supramolecular hydrogel
  • Method for compounding active ingredients in rhizoma acori graminei by utilizing oligopeptide supramolecular hydrogel

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Embodiment Construction

[0024] The present invention is described in detail below in conjunction with accompanying drawing and specific embodiment:

[0025] A method of utilizing short peptide supramolecular hydrogels to compound active ingredients in Acorus calamus, including β-asarone, α-asarone, eugenol methyl ether and isoeugenol methyl ether extracted from the volatile oil of Acorus calamus. β-Asarone, α-Asarone, Eugenol Methyl Ether and Isoeugenol Methyl Ether can form a weak hydrogel and then form a composite supramolecular hydrogel factor through phenylalanine + chitosan, The composite supramolecular hydrogel factor was assembled into a composite supramolecular hydrogel in PBS buffer solution with a pH of 7.4, and the specific steps were as follows: (1) Drug stock solution: α-asarone, β- Asarone, eugenol methyl ether and isoeugenol methyl ether were first dissolved in ethanol, and then prepared into a 10 mmol / L mixed solution, which was stored in a refrigerator at 4°C for later use; (2) Comme...

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Abstract

The invention discloses a method for compounding active ingredients in rhizoma acori graminei by utilizing oligopeptide supramolecular hydrogel. The method comprises the following steps: obtaining a compound supramolecular hydrogel factor by utilizing an activated commercial amino acid; and diluting an ethanol solution of the compound supramolecular hydrogel factor to 0.5%(w / v) with PBS with the pH value of 7.4, and ultrasonically heating and cooling in a short time, thereby obtaining the compound supramolecular hydrogel. The compound supramolecular hydrogel prepared by the method disclosed by the invention is simple and cheap, has multiple response properties, is hydrogel at a high concentration and is a nanosphere at a low concentration. The change between the hydrogel and the nanosphere can be used for controlling slow release of active ingredients in rhizoma acori graminei, so that long-term inhibition of Alzheimer's disease is realized.

Description

technical field [0001] The invention relates to a composite supramolecular hydrogel factor, a hydrogel and a preparation method thereof. In particular, it relates to a method for preparing multi-responsive, multi-functional supramolecular hydrogels by chemically modifying and linking aromatic phenylalanine through aromatic stacking and hydrogen bond self-assembly. Background technique [0002] Alzheimer's disease (AD), commonly known as senile dementia, is a progressive, chronic, and fatal neurodegenerative disease that mostly occurs in the elderly. The main symptoms are memory loss, cognitive impairment, and language decline. At present, AD is still a serious disease that cannot be cured. Therefore, the effective prevention and treatment of AD has attracted worldwide attention. Amyloid fibrils formed by the abnormal aggregation and self-assembly of polypeptide Aβ are considered to be the main pathogenic factor of AD. This abnormally aggregated Aβ is a strong hydrophobic s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61K9/06A61K31/09A61K47/54A61P25/28
CPCA61K9/06A61K31/09A61K36/888A61K2300/00
Inventor 张翼吴慧琼方飞苏骋
Owner 苏州天茹生物科技有限公司
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