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Dextromethorphan hydrobromide slow-release dry suspension and preparation method thereof

A technology of dextromethorphan hydrobromide and dry suspension, which can be applied to pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as technical difficulties and unfavorable physical properties

Inactive Publication Date: 2017-07-21
刘宏飞
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Applicants believe that this is at least in part because certain physical properties of dextromethorphan hydrobromide are unfavorable for preparation as a conventional extended release dry suspension, and therefore an extended release dry suspension of dextromethorphan hydrobromide was prepared Formulation is technically difficult for those skilled in the art

Method used

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  • Dextromethorphan hydrobromide slow-release dry suspension and preparation method thereof
  • Dextromethorphan hydrobromide slow-release dry suspension and preparation method thereof
  • Dextromethorphan hydrobromide slow-release dry suspension and preparation method thereof

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preparation example Construction

[0017] 1. Preparation of Drug Resin

[0018] An appropriate amount of deionized water is added to the cation exchange resin, the drug is added under stirring and mixed evenly, and samples are taken regularly to measure the concentration of the drug in the solution. When the drug concentration no longer changes with time, the equilibrium is reached, the unbound drug on the surface of the resin is washed away with deionized water, and the drug-loaded resin is obtained by drying at 40°C-60°C.

[0019] 2. Impregnation of drug resin

[0020] Take an appropriate amount of drug-loaded resin, add it to 20% PEG4000 aqueous solution, stir for 0.5 hour, dry and sieve to obtain impregnated drug resin.

[0021] 3. Preparation of Drug Resin Microcapsules

[0022] Using bottom-spray fluidized bed equipment, put 150g of impregnated drug resin of 180-200μm into the fluidization chamber, use a spray gun with a nozzle diameter of 1mm, adjust the air volume so that the particles are in an ideal...

Embodiment 1

[0029]

[0030]

Embodiment 2

[0032]

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Abstract

The invention discloses a slow-release dry suspension of dextromethorphan hydrobromide which is slowly released in the gastrointestinal tract environment. The formulation contains dextromethorphan hydrobromide and a pharmaceutically acceptable polymer. According to weight percentage, the preparation contains 10-90% of dextromethorphan hydrobromide and 10-90% of auxiliary materials. The supplementary materials for sustained release are one or more of cation exchange resin, methyl cellulose, ethyl cellulose, acrylic resin and hydroxypropyl methyl cellulose. Compared with the immediate-release preparation, the controlled-release preparation of the present invention can maintain the effective blood drug concentration within 24 hours, improve the curative effect, have less toxic and side effects, be convenient to take and carry, and reduce the number of times of taking. The sustained-release preparation of the invention can maintain a more stable blood drug concentration within 24 hours, improve curative effect, and have less toxic and side effects. This preparation only needs to be administered once a day. The controlled-release preparation of the present invention will be clinically used as an antitussive.

Description

technical field [0001] The invention relates to antitussive drug dextromethorphan hydrobromide slow-release dry suspension and a preparation method thereof. Background technique [0002] Dextromethorphan is the dextroisomer of morphine-like levomorphan methyl ether, which exerts a central antitussive effect by inhibiting the medullary cough central reflex to increase the cough threshold of the central nervous system. Its antitussive strength is equal to or slightly stronger than codeine. However, there is no analgesic and sedative effect of codeine, and there is no tolerance and addiction in long-term application. Therapeutic dosage does not inhibit respiratory center and mucous membrane secretion of respiratory tract. It has remarkable antitussive effect in clinical application, low incidence of adverse reactions, good oral absorption, onset of effect in 15-30 minutes, and can last for 3-6 hours, with t1 / 2 of 5 hours. It is widely used in clinical antitussive therapy beca...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K9/52A61K31/485A61K47/32A61K47/38A61P11/14
CPCA61K31/485A61K9/0095A61K9/5026A61K9/5042A61K47/32
Inventor 刘宏飞
Owner 刘宏飞
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