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Preparation method for natural bone repairing material capable of accelerating osteanagenesis

A technology for repairing materials and natural bone, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of artificial bone repair materials such as unsatisfactory compressive strength and elastic modulus, low amount of osteogenesis, lack of osteoinductivity, etc. , to achieve good osteoinductive activity, fast repair, and high mechanical strength

Inactive Publication Date: 2017-07-14
常州力纯数码科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem mainly solved by the present invention: aiming at the defects that the existing bone repair materials only have osteoconductivity, lack of osteoinductivity, less osteogenesis, and the compressive strength and elastic modulus of the artificial bone repair materials are not ideal, provide A kind of preparation method of promoting bone regeneration bone repair material

Method used

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  • Preparation method for natural bone repairing material capable of accelerating osteanagenesis

Examples

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Effect test

example 1

[0015] Weigh 1 kg of fresh bovine bone, wash the bovine bone with deionized water for 3 times, then add the washed bovine bone to 2L of deionized water, cook at 95°C for 3 hours, take out the bovine bone after cooling to room temperature, and remove the bovine bone with a scraper Surface soft tissue, get pretreated bovine bone, soak the pretreated bovine bone in 2L of 4% sodium hydroxide solution at 60°C for 6 hours, take out the bovine bone and transfer it to 1L of 30% hydrogen peroxide Soak for 10 hours, take out the bovine bones, and get the impurity-removed bovine bones, then soak and clean the impurity-removed bovine bones with 1L of absolute ethanol for 1 hour, then transfer them to a blast drying oven, and dry them at 105°C to constant weight. The final product is put into a pulverizer and pulverized, passed through a 20-mesh sieve to obtain crude calcium phosphate, then put the crude calcium phosphate into a muffle furnace, heat up to 500°C at a rate of 5°C / min, and aft...

example 2

[0017] Weigh 1 kg of fresh bovine bone, wash the bovine bone with deionized water 4 times, then add the washed bovine bone to 2L of deionized water, cook at 98°C for 4 hours, take out the bovine bone after cooling to room temperature, and remove the bovine bone with a scraper Surface soft tissue, get pretreated bovine bone, soak the pretreated bovine bone in 2L of 4% sodium hydroxide solution at 65°C for 7 hours, take out the bovine bone and transfer it to 1L of 30% hydrogen peroxide Soak for 11 hours, take out the bovine bones to get the impurity-removed bovine bones, then soak and clean the impurity-removed bovine bones with 1L of absolute ethanol for 1 hour, then transfer them to a blast drying oven, and dry them at 108°C to constant weight. The final product is put into a pulverizer and pulverized, passed through a 20-mesh sieve to obtain crude calcium phosphate, then put the crude calcium phosphate into a muffle furnace, heat up to 550°C at a rate of 8°C / min, and after cal...

example 3

[0019]Weigh 2kg of fresh bovine bones, wash the bovine bones with deionized water for 5 times, then add the washed bovine bones to 3L of deionized water, cook at 100°C for 5 hours, take out the bovine bones after cooling to room temperature, and remove the bovine bones with a scraper Surface soft tissue, get pretreated bovine bone, soak the pretreated bovine bone in 3L of 4% sodium hydroxide solution at 70°C for 8 hours, take out the bovine bone and transfer it to 2L of 30% hydrogen peroxide Soak for 12 hours, take out the bovine bone, and get the impurity-removed bovine bone, then soak and clean the impurity-removed bovine bone with 2L of absolute ethanol for 2 hours, then transfer it to a blast drying oven, dry it at 110°C to constant weight, and then dry it The final product is put into a pulverizer and pulverized, passed through a 20-mesh sieve to obtain crude calcium phosphate, then put the crude calcium phosphate into a muffle furnace, heat up to 600°C at a rate of 10°C / m...

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Abstract

The invention discloses a preparation method for a natural bone repairing material capable of accelerating osteanagenesis, and belongs to the technical field of medical materials. The preparation method comprises the following steps: calcining by taking ox bones as raw materials, generating a high-intensity alpha-tricalcium phosphate crystal form and a high-degradability high-bioactivity excellent-osteoinductivity beta-tricalcium phosphate crystal form; then, compounding with carboxymethylcellulose to prepare composite powder; mixing with deionized water for carrying out compression moulding, and drying to obtain a bracket material; subsequently, mixing bone morphogenetic protein, platelet-derived growth factors and phosphate buffer to prepare phosphate nutrient solution; then, dipping the bracket material in the phosphate nutrient solution for culture growth; finally, taking out, drying and sterilizing the bracket material to obtain the natural bone repairing material capable of accelerating osteanagenesis. The bone repairing material prepared with the preparation method has the advantages of high mechanical strength, good biocompatibility with the human body, good osteoinductive activity, good biodegradability and a wide application prospect, and bone defect repair can be quickly finished.

Description

technical field [0001] The invention discloses a preparation method of a natural bone repair material for promoting bone regeneration, and belongs to the technical field of medical material preparation. Background technique [0002] Currently, there are autologous bone grafts, allogeneic bone grafts, and artificial bone substitutes in clinical practice for bone repair in the world. Autologous bone transplantation has limitations such as donor site damage, insufficient bone graft volume, and inability to prepare special shapes. Allogeneic bone is prone to rejection, while artificial synthetic bone has better osteoconductivity and certain mechanical strength. It acts as a scaffold to guide bone regeneration, and then it is slowly biodegraded and removed. It has good osteoconductivity. Therefore, artificial bone repair materials have gradually become the main materials for clinical bone defect repair in the world. [0003] At present, there are many types of artificial bone re...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/20A61L27/22A61L27/56A61L27/50
CPCA61L27/12A61L27/20A61L27/227A61L27/50A61L27/56A61L2300/112A61L2300/232A61L2300/412A61L2300/414A61L2430/02C08L1/286C08L89/00
Inventor 邹家宾杨阳孙冬
Owner 常州力纯数码科技有限公司
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