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Neonatal microbiome supplementation

A microbiological, neonatal technology, applied in the field of improving the chances of life outside the womb, supplementing the microbiome of newborns, can solve the problem of NEC without effective cure or treatment

Inactive Publication Date: 2017-06-20
BIOGAIA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

NEC is considered the second most common cause of mortality among premature infants in the United States, and sadly there is currently no effective cure or treatment for NEC

Method used

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  • Neonatal microbiome supplementation
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] Manufacture of chewing gum products containing probiotic strains

[0096] In this example, Lactobacillus reuteri DSM 17938 or ATCC 5289 (FJ1) was chosen for addition of the strains to chewing gum. Lactobacillus reuteri was grown and lyophilized using standard methods used in the industry for growing Lactobacilli.

[0097] The steps of an example manufacturing method of chewing gum comprising selected strains are as follows, it being understood that excipients, fillers, flavours, encapsulators, lubricants, anti-caking agents, sweeteners and other components of the chewing gum product as known in the art Components can be used without affecting product efficacy:

[0098] 1 melted. Softisan 154 (SASOL GMBH, Bad Homburg, Germany) was melted in a vessel and heated to 70°C to ensure complete fragmentation of the crystal structure. It is then cooled to 52 - 55°C (just above its hardening point).

[0099] 2 Granulation. Transfer the L. reuteri freeze-dried powder to a Di...

Embodiment 2

[0108] A test group of pregnant women was included in one study. A subgroup of the test group received L. reuteri strain ATCC PTA 5289 in the form of lyophilized powder in standard gelatin capsules, while the other subgroup of the test group received L. reuteri DSM 17938 in the form of chewing gum. The probiotics were given during the women's last trimester of pregnancy. Lactobacillus reuteri strain ATCC PTA 5289 is in gelatin capsule form because the desired probiotic effect occurs in the mother's digestive tract. On the other hand, Lactobacillus reuteri DSM 17938 was orally administered to the mother in the form of chewing gum to maximize the exposure time and site-specific exposure in the oral cavity, and thus successfully colonized the oral cavity. After colonization in the mother's mouth, the probiotic bacteria can then disseminate via the bloodstream to the placenta and further to the baby's digestive tract.

[0109] Fecal samples may be collected from each subject on ...

Embodiment 3

[0114] Pregnant mothers treated with probiotics to reduce risk of bearing children with suboptimal gastrointestinal microbiomes. Pregnant mothers will take oral probiotics during their pregnancy, preferably certain lactic acid bacteria such as Lactobacillus reuteri DSM 17938, and thereby transfer them to the fetus through the blood and placenta.

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Abstract

The present invention aims to prevent and / or treat health-related conditions in infants born with a non-optimal intestinal microbiome, by providing specific probiotic lactic acid bacterial strains to the pregnant mother. This will enable early colonization of the infant gut, even before birth, and thus prevent and / or treat health-related conditions associated with non- optimal microbiome. Thus, the present invention provides a probiotic microorganism for use in the treatment of a fetus or neonate, wherein said probiotic microorganism is administered to the oral cavity of a pregnant female in a formulation suitable to colonize the oral cavity, wherein said probiotic microorganism is thereby administered to the fetus. The methods and uses of the invention can also provide for the colonization of a fetus or neonate or for shifting the microbiome of a fetus or neonate.

Description

[0001] field of invention [0002] The present invention relates generally to the neonatal microbiome. More specifically the invention relates to methods for replenishing the microbiome of newborns. The present invention relates to the early colonization of the neonatal microbiome by probiotic bacteria and thus improving the chances of life outside the womb. Such early colonization will prevent and / or treat health-related diseases or conditions associated with infants born with non-optimal gut flora. [0003] Background of the invention [0004] The human microbiome is the total collection of all microorganisms (eg, bacteria, fungi, and viruses) that inhabit the surface and deep layers of the skin, in the nasal and oral cavity, in the gastrointestinal tract, in the genitourinary system, and elsewhere in the human body. Bacterial cells used to be considered only harmful because of their ability to cause infection. However, there are certain beneficial characteristics associat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/745A61K35/747A61P1/00
CPCA61K35/745A61K35/747A61P1/00A61P1/02A61P1/06A61P13/00A61P13/02A61P31/00A61K9/0053A61K9/20
Inventor B.梅尔斯塔姆K.亚加尔德
Owner BIOGAIA AB
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