Preparation for treating alopecia

A preparation and solvent technology, applied in the field of drugs for the treatment of hair loss, can solve the problems of expensive equipment, unstable curative effect, unclear ingredients, etc., and achieve the effects of avoiding drug dependence, clear mechanism of action, and avoiding side effects

Inactive Publication Date: 2017-05-31
李玉红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. The use of traditional Chinese medicine or Chinese patent medicine: its disadvantage is that it is a compound preparation with unclear ingredients, which is difficult to promote globally, and its curative effect is unstable;
[0005] 2. Western medicine: the use of immunomodulators and hormones, hormones will bring obvious side effects and drug

Method used

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  • Preparation for treating alopecia
  • Preparation for treating alopecia
  • Preparation for treating alopecia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A preparation method for a spray for treating hair loss is as follows: according to the conventional method, take 20g lithium chloride, 1gLDN-193189 to make a very fine powder, add 50ml polysorbate 80 as surfactant and wetting agent, mix Evenly, then add 10ml of glycerin as a thickener, and finally add distilled water to 100ml, stir and mix evenly, and divide into spray bottles to prepare a spray with lithium chloride and LDN-193189 as active ingredients.

[0030] The detection method is as follows: take 4 C57BL / 6 mice at 56 days old, the hair follicles of the mice are in the absolute quiescent phase, inject 150ul of 1% pentobarbital sodium intraperitoneally, and cut off the small hair follicles with scissors after the mice are anesthetized. For the hair on the back of the mouse, it should be noted that the skin should not be cut, and a circular area with a diameter of about 3 cm was drawn on the back skin along the midline of the back with a marker pen as the preparatio...

Embodiment 2

[0033] A preparation method for an injection for treating alopecia is as follows: according to a conventional method, respectively weigh 25g of sodium bicarbonate, 200g of lithium chloride, and 5g of LDN-193189, add 80% of the water for injection in the configuration container, and usually Into CO 2 To saturation, add lithium chloride to dissolve, slowly add sodium bicarbonate, stir to dissolve completely, then add LDN-193189 and stir evenly, adjust the pH value of the mixture in the range of 6.0 to 6.2, add 2 After the saturated water for injection reached 1000ml, it was repeatedly filtered with a microporous membrane, and in CO 2 Potting under air flow, and finally sterilizing in circulating steam at 100°C for 15 minutes to prepare an injection with lithium chloride and LDN-193189 as active ingredients.

[0034]The detection method is as follows: take 3 C57BL / 6 mice at 56 days old and inject 150ul of 1% sodium pentobarbital intraperitoneally. After the mice are anesthetized...

Embodiment 3

[0037] A kind of preparation method of the ointment that is used to treat alopecia is as follows: according to routine method, take by weighing 120g stearic acid, 35g glyceryl monostearate, 10g petrolatum, 50g lanolin, 60g liquid paraffin, 1.5g ethylparaben , 4g triethanolamine, 50g glycerin, 550g lithium chloride, 50g LDN-193189, 69.5g distilled water, wherein triethanolamine reacts with part of stearic acid to generate organic ammonium soap as emulsifier, part of stearic acid is the oil phase base, single Glyceryl stearate increases the water absorption of the oil phase as a stabilizer, liquid paraffin and vaseline are used to adjust the consistency, lanolin is used to increase the water absorption of the matrix, glycerin is a humectant, and ethylparaben is a preservative. Put the weighed stearic acid, glyceryl monostearate, vaseline, liquid paraffin, and lanolin into the configuration container, heat it in a water bath to 70-80°C to melt it as the oil phase; Add phenethyl e...

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Abstract

The invention belongs to the technical field of medicines treating alopecia and in particular relates to a preparation for treating alopecia. The preparation comprises lithium chloride, LDN-193189, a carrier or an excipient. The inventor provided by the invention performs a lot of theoretical researches in an early stage, finds two critical target points of regulating hair follicle growth, and designs the invention for the two target points, i.e., a classical Wnt signal and an antagonistic BMP signal are activated while the compound is combined in use, so that action of biological macromolecules is simulated to achieve a purpose of inducing hair follicle growth. By using the compounds lithium chloride and LDN-193189, the preparation is definite in component, clear in action mechanism and obvious in curative effect on animals and can effectively solve the problem of treating alopecia. Moreover, according to the pharmaceutical composition provided by the invention, the hair follicles induced and generated on a C57 mouse are black, so that the preparation provided by the invention can be also used for treating grey hair.

Description

technical field [0001] The invention belongs to the technical field of medicines for treating alopecia, in particular to a preparation for treating alopecia. Background technique [0002] Hair is produced by hair follicles, and hair follicles have the characteristics of periodic regeneration, that is, a cycle of growth, catagen, and resting phases. Among them, the conversion from the stationary phase to the growth phase, that is, the initiation of the growth phase is the most critical link. When the periodic regeneration function of hair follicles is disturbed, hair follicle-related diseases such as hair loss and alopecia areata will appear. Human hair not only has biological and physiological functions, but also has important psychological and sociological functions because the thickness of hair and hairstyle have obvious effects on human appearance. At present, with the improvement of living standards, people's requirements for beauty are becoming increasingly urgent. S...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/12A61K47/26A61K47/02A61K9/06A61K47/44A61K9/08A61K47/20A61P17/14A61P17/00A61K31/519
CPCA61K47/02A61K47/20A61K47/26A61K47/44A61K9/0019A61K9/06A61K9/08A61K9/12A61K31/519A61K33/14A61K2300/00
Inventor 李玉红
Owner 李玉红
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