Radix ophiopogonis oligosaccharide slow-release tablet and preparation method thereof
A technology of sustained-release tablets and oligosaccharides, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of large fluctuations in blood drug concentration, short half-life, and frequent medication , to achieve the effect of ensuring curative effect, simple preparation process, and reducing excessive blood drug concentration
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Embodiment 1
[0013] 1. Preparation of Ophiopogon japonicus oligosaccharides: Cut the medicinal material of Ophiopogon japonicus into pieces, reflux with 10 times the volume of 95% ethanol for 2 hours and then filter, discard the filtrate, evaporate to dryness with 95% ethanol with the medicinal material, add 10 times the volume of pure water to extract in a 100°C water bath Once, filter with suction, collect the filtrate and concentrate under reduced pressure to a density of 1.2g / ml, add 80% ethanol, let it stand for 12 hours, discard the ethanol solution after the sugar is precipitated, wash with absolute ethanol, anhydrous ether, and acetone respectively, Dry the precipitate at 55°C to obtain crude oligosaccharides. Dissolve crude oligosaccharides in water at a concentration of centrifugation to remove precipitation, use Sephadex G-75 chromatography column, elute with distilled water, detect with anthrone-sulfuric acid method, collect, combine elution peaks, and freeze-dry to obtain Ophio...
Embodiment 2
[0018] 1. The preparation of Ophiopogon japonicus oligosaccharides is the same as in Example 1.
[0019] 2. Preparation of sustained-release tablets
[0020] Formula: Ophiopogon japonicus oligosaccharide 100g, hydroxypropyl methylcellulose 100g, carboxyethyl cellulose 20g, lactose 10g, starch 20g, magnesium stearate 0.75g, micropowder silica gel 0.75g.
[0021] Preparation method: Mix the above materials evenly, granulate with 95% ethanol, dry, add lubricant and compress into tablets. 1000 tablets are prepared. After release measurement, the results showed that the sustained-release tablet released 10-30%, 30-60%, and 80% of the labeled amount in 2 hours, 4 hours, and 8 hours, respectively, meeting the release requirements of sustained-release preparations.
Embodiment 3
[0023] 1, the preparation of Ophiopogon japonicus oligosaccharide is identical with embodiment 1
[0024] 2. Preparation of sustained-release tablets
[0025] Recipe: Ophiopogon oligosaccharides 100g, hydroxymethylpropylcellulose 85g, sodium carboxymethylcellulose 65g, lactose 10g, microcrystalline cellulose 10g, magnesium stearate 1.5g.
[0026] Preparation method: Mix the above materials evenly, granulate with 95% ethanol, dry, add lubricant and compress into tablets. 1000 tablets are prepared. After release measurement, the results showed that the sustained-release tablet released 10-30%, 30-60%, and 80% of the labeled amount in 2 hours, 4 hours, and 8 hours, respectively, meeting the release requirements of sustained-release preparations.
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