Polyether polyurethane material containing phosphorylcholine group on side chain and preparation method thereof

Abstract

The invention relates to a polyether polyurethane material containing a phosphorylcholine group on a side chain and a preparation method thereof. The preparation method comprises the following steps: (1) enabling polyether glycol to react with excess diisocyanate to obtain a two-end isocyanate-based prepolymer; (2) performing chain extension on the two-end isocyanate-based prepolymer by taking a bis-amino phosphorylcholine compound as a chain extender to obtain phosphorylcholine modified polyurethane. The process is simple and feasible; moreover, the phosphorylcholine group is positioned on the side chain of a polymer, and is accumulated on the surface of the material when being applied to an organism, so that the biocompatibility of the material is enhanced greatly, and the absorption of proteins and platelets in blood is very low. A membrane prepared from the material has high mechanical strength and flexibility; the used diisocyanate is fat diisocyanate which contains a plurality of urethane groups, so that a degradation product is non-toxic and can be absorbed by the organism.

Description

technical field [0001] The invention belongs to the field of medical polymer materials, in particular to a polyether type polyurethane material containing phosphorylcholine group in the side chain and a preparation method thereof. Background technique [0002] Polyurethane has the advantages of various design methods, good biocompatibility, high mechanical strength, wear resistance, fatigue resistance, high elasticity, easy processing, non-toxic and harmless, and easy to be absorbed by the human body. It is an environmentally friendly functional material. It has a wide range of applications in the field of biomedical materials such as artificial tissues, bionic skin, medical sponges, postoperative sutures, and slow-release system substrates. However, although artificial organs made of polyurethane or medical devices in contact with the human body have good biocompatibility, it is found in clinical use that the surface of artificial organs made of polyurethane materials, such...

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Problems solved by technology

[0008] Among them, the modified method of inserting phosphorylcholine groups on the surface of polyurethane materials is to soak the polyurethane film in a solvent containing phosphorylcholine to react so that the surface first introduces primary amino groups, but the phosphorylcholine that is inserted The group is unstable and easy to fall off under external conditions, and the method is complicated, the cost is high, and it is difficult to industrialize production; the modification method of blending the polymer containing the phosphorylcholine group with the polyurethane material improves the original polyurethane material. However, it is found that when the amount of the polymer containing phosphorylcholine group is large, the mechanical properties of the material will be reduced; the double-terminal hydroxyl compound containing phosphorylcholine group is synthesized and then extended to prepare the main Modification method of polyurethane chain containing phosphorylcholine group The phosphorylcholine group contained in the material is completely located on the main chain, and a considerable part of the choline group is embedded in the material during the use of the material. It is difficult to enrich on the surface of the material, and the utilization rate of the phosphorylcholine group is reduced, resulting in limited improvement of the biocompatibility of the material, and the preparation is difficult and the cost is high.

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