Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Absorbable medical biological membrane and preparation method thereof

A biofilm and bioactive factor technology, applied in the field of absorbable medical biofilm and its preparation, and three types of implantable medical devices, can solve the problems of tissue damage, repair failure, and poor biocompatibility of materials

Inactive Publication Date: 2017-02-15
天津欧尔克医药科技有限公司
View PDF6 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Autologous tissue has good compatibility and will not produce an immune response. However, autologous tissue will cause damage to its own tissue while repairing the dura mater. It is also limited by the size and shape of the material. The operation is complicated and easy to be infected. Currently, it is not widely used.
Artificial synthetic materials such as polylactic acid and polyglycolic acid will cause local acidity to be too high when degraded in the human body, resulting in poor biocompatibility of the material. In addition, artificially synthesized degradable polymer materials degrade too quickly in the human body, which will cause repair failure

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: Preparation of absorbable medical biofilm

[0025] 1) Material collection: Collect the pericardium tissue of 2-3 year old cattle, cut and remove the irregular part of the pericardium and the sticky fat layer on the rough surface.

[0026] 2) Tissue decellularization treatment: place the bovine pericardium tissue in pure water, at room temperature 25°C, shake at 100rpm for 2h, and then place it in 10% sodium chloride solution, at room temperature at 25°C, shake at 100rpm for 2h. As a cycle, a total of 1-3 times of circulation treatment; then placed in 1.0% sodium dodecylsulfonate (SDS), 100rpm shaking treatment for 12h.

[0027] 3) Adding growth factors: using a low-pressure infiltration method with a pressure range of 300 Pa to infiltrate the growth factors into the prepared patch.

[0028] 4) Final sterilization: using Co 60 Sterilized by γ-ray irradiation, the sterilization dose is 15kGy.

Embodiment 2

[0029] Embodiment 2: Preparation of absorbable medical biofilm

[0030] 1) Material collection: Collect pericardium tissue from pigs aged 1-2 years, cut and remove the irregular part of the pericardium and the sticky fat layer on the rough surface.

[0031] 2) Tissue decellularization treatment: the pericardial tissue was placed in pure water, 22°C at room temperature, 100rpm shaking for 2h, then placed in 10% sodium chloride solution, 22°C at room temperature, 100rpm shaking for 2h, as One cycle, a total of 1-3 cycles; then placed in 1.0% sodium dodecylsulfonate (SDS), 100rpm shaking treatment for 10h, and finally placed in 1.0% TritonX-200, 100rpm shaking treatment for 2h.

[0032] 3) Adding growth factors: using a low-pressure infiltration method with a pressure range of 200 Pa to infiltrate the growth factors into the prepared patch.

[0033] 4) Final sterilization: using Co 60 Sterilized by γ-ray irradiation, the sterilization dose is 25kGy.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an absorbable medical biological membrane and a preparation method of the absorbable medical biological membrane. The biological membrane is prepared by taking animal pericardium, pleura or intestinal film as an animal source collagen membrane material, and performing a decellularized treatment, adding biological active factors and performing a sterilizing process. Compared with the prior art, the absorbable medical biological membrane and the preparation method thereof, created by the invention, have the advantages that the biological membrane selected from the animal source membrane base material with wide origin and performed with antigen removal treatment and sterilizing treatment is high in histocompatibility, and can degrade in a human body; the addition of growth factors can accelerate the wound healing. The biological membrane prepared by the preparation method is in milky white, and has better flexibility and is closer to natural living tissues, not easy to calcify, and applicable to repair defected soft tissues in surgical operation, such as the repair of cerebral dura mater or spinal meninges defect caused by brain and spinal cord injury, cancer and other brain diseases.

Description

technical field [0001] The invention relates to a medical product used for defect soft tissue repair in surgical operations, which belongs to three types of implantable medical devices, in particular to an absorbable medical biofilm and a preparation method thereof. Background technique [0002] Due to its low immunogenicity, collagen is often used as a medical biomaterial. In modern surgery, it can repair soft tissue defects, such as the dura mater or spinal cord caused by craniocerebral, spinal cord injuries, tumors and other craniocerebral diseases. Repair of membrane defects. In my country, there are as many as 130,000 primary intracranial tumors each year, plus the pathology of meningeal repair due to recurrent intracranial tumors, car accidents and other craniocerebral trauma, the total number can reach more than 800,000 cases per year. According to the source and performance, there are four types of dura mater repair materials currently being used in research and app...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/36A61L27/54A61L27/58
CPCA61L27/3604A61L27/3675A61L27/3695A61L27/54A61L27/58A61L2300/414A61L2400/02A61L2430/34
Inventor 蒋彩云
Owner 天津欧尔克医药科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com