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Reinforced reactive injectable bone cement and preparation method thereof

A technology for enhancing activity and bone cement, applied in the field of medical materials, it can solve the problems of weak integration with bone, inability to absorb and degrade, poor biocompatibility, etc. Effect

Inactive Publication Date: 2017-01-04
林春梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

PMMA bone cement can be injection molded and made into any shape, and has high mechanical strength. However, PMMA bone cement still has some limitations. For example, the monomer has certain toxicity, poor biocompatibility, and cannot be absorbed and degraded after being injected into the human body. It has no osteogenic effect, is not firmly combined with bone, and is easy to loosen. The polymerization process is an exothermic reaction, and the local temperature is as high as 100°C. If leakage occurs, it may cause functional damage such as nerves.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] An injectable bone cement with enhanced activity, comprising the following components in parts by weight: 35 parts of tricalcium phosphate, 16 parts of polylactic acid, 9 parts of calcium sulfate, 2 parts of coral powder, 1 part of ferulic acid, silk fibroin 2 parts protein, 4 parts talcum powder, 6 parts barium sulfate, 0.5 parts velvet peptide, 2 parts gastrodin, 4 parts vitamin C, 2 parts zinc oxide, 0.7 parts tantalum oxalate, 3 parts polyetheretherketone, polyvinylpyrrolidone 2 parts, 1 part of methyl-β-cyclodextrin, 5 parts of maleylated chitosan, 45 parts of normal saline.

[0022] A preparation method of enhanced active injectable bone cement, the specific preparation steps are:

[0023] S1. Mix and stir polylactic acid, lugua polypeptide, gastrodin, vitamin C, ferulic acid and normal saline evenly to obtain solution A for later use;

[0024] S2. Add tricalcium phosphate, calcium sulfate, zinc oxide and tantalum oxalate into distilled water, heat to 80° C., and...

Embodiment 2

[0029] An injectable bone cement with enhanced activity, comprising the following components in parts by weight: 48 parts of tricalcium phosphate, 25 parts of polylactic acid, 18 parts of calcium sulfate, 7 parts of coral powder, 4 parts of ferulic acid, silk fibroin 5 parts of egg white, 8 parts of talcum powder, 11 parts of barium sulfate, 3 parts of melon polypeptide, 6 parts of gastrodin, 9 parts of vitamin C, 6 parts of zinc oxide, 4 parts of tantalum oxalate, 9 parts of polyetheretherketone, polyvinylpyrrolidone 6 parts, 4 parts of methyl-β-cyclodextrin, 11 parts of maleylated chitosan, 67 parts of normal saline.

[0030] A preparation method of enhanced active injectable bone cement, the specific preparation steps are:

[0031] S1. Mix and stir polylactic acid, lugua polypeptide, gastrodin, vitamin C, ferulic acid and normal saline evenly to obtain solution A for later use;

[0032] S2. Add tricalcium phosphate, calcium sulfate, zinc oxide and tantalum oxalate into dis...

Embodiment 3

[0037] An injectable bone cement with enhanced activity, comprising the following components in parts by weight: 37 parts of tricalcium phosphate, 18 parts of polylactic acid, 10 parts of calcium sulfate, 3 parts of coral powder, 1.5 parts of ferulic acid, silk fibroin 2.4 parts of protein, 4.6 parts of talcum powder, 6.5 parts of barium sulfate, 0.8 parts of deer melon polypeptide, 2.3 parts of gastrodin, 4.7 parts of vitamin C, 3 parts of zinc oxide, 0.9 parts of tantalum oxalate, 3.6 parts of polyetheretherketone, polyvinylpyrrolidone 2.4 parts, 1.3 parts of methyl-β-cyclodextrin, 5.8 parts of maleylated chitosan, 48 parts of normal saline.

[0038] A preparation method of enhanced active injectable bone cement, the specific preparation steps are:

[0039] S1. Mix and stir polylactic acid, lugua polypeptide, gastrodin, vitamin C, ferulic acid and normal saline evenly to obtain solution A for later use;

[0040] S2. Add tricalcium phosphate, calcium sulfate, zinc oxide and ...

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Abstract

The invention discloses a reinforced reactive injectable bone cement and a preparation method thereof. The bone cement comprises the following components: tricalcium phosphate, polylactic acid, calcium sulphate, coral powder, ferulic acid, silk fibroin, talcum powder, barium sulfate, cervus and cucumis polypeptide, gastrodin, vitamin C, zinc oxide, tantalum oxalate, PEEK(polyether-ether-ketone), polyvinylpyrrolidone, methyl-beta-cyclodextrin, maleyl chitosan and normal saline. The injectable bone cement provided by the invention is excellent in syringeability, the compressive strength and the bending strength are high, and the mechanical property requirements of a bone repair material are met. In addition, the bone cement provided by the invention is good in cell compatibility, is relatively good in osteoconduction, is convenient for promoting the self-healing repair of bone tissue, and improves the firmness in the combination of the bone cement and bone, thereby well meeting clinic application requirements.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to an enhanced activity injectable bone cement and a preparation method thereof. Background technique [0002] Polymethyl methacrylate (PMMA) bone cement is the most commonly used bone cement in clinical practice. It consists of powder and liquid. The main component of the powder is PMMA, and the main component of the liquid is MMA monomer. PMMA bone cement can be injection molded and made into any shape, and has high mechanical strength. However, PMMA bone cement still has some limitations. For example, the monomer has certain toxicity, poor biocompatibility, and cannot be absorbed and degraded after being injected into the human body. It has no osteogenic effect, is not firmly combined with the bone, and is easy to loosen. The polymerization process is an exothermic reaction, and the local temperature is as high as 100°C. If leakage occurs, it may cause funct...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/12A61L27/02A61L27/36A61L27/22A61L27/16A61L27/18A61L27/20
CPCA61L27/50A61L27/025A61L27/12A61L27/16A61L27/18A61L27/20A61L27/227A61L27/3604A61L2400/06A61L2430/02C08L89/00C08L39/06C08L61/16C08L5/08C08L5/16
Inventor 林春梅
Owner 林春梅
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