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Method for determination of acetaldehyde in electronic cigarette liquid

A technology of e-cigarette liquid and determination method, which is applied to measurement devices, instruments, scientific instruments, etc., can solve the problems of large differences in substrates, large differences in additives, and complex substrates of e-cigarette liquids, so as to prevent aggregation, Good solubility, good solubility effect

Inactive Publication Date: 2016-12-07
ZHENGZHOU TOBACCO RES INST OF CNTC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, due to the wide variety of e-liquid brand specifications and the large differences in the additives of different flavors of e-liquid, the e-liquid matrix is ​​relatively complex, and the matrix of different e-liquid samples varies greatly

Method used

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  • Method for determination of acetaldehyde in electronic cigarette liquid
  • Method for determination of acetaldehyde in electronic cigarette liquid
  • Method for determination of acetaldehyde in electronic cigarette liquid

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0032] Acetaldehyde-2,4-dinitrophenylhydrazone standard solution was analyzed by LC-MS / MS. Perform regression analysis on the peak area ratio of the target substance and internal standard quantitative ion pair and the concentration of acetaldehyde to obtain the standard working curve and regression equation of acetaldehyde, and calculate the limit of detection (LOD) with 3 times the signal-to-noise ratio (S / N = 3), The specific test results are shown in Table 2:

[0033] Table 2 Test results of acetaldehyde standard working solution

[0034] compound

example 2

[0036] The standard addition recovery experiment was carried out at three concentration levels of low, medium and high. Each standard addition level was repeated 5 times, and the recovery rate and precision of each addition level were calculated according to the measured amount and the standard addition amount. The specific results are shown in the following table:

[0037] Table 3 method recovery and repeatability

[0038]

example 3

[0040]Weigh 0.2 g of an e-cigarette liquid sample, add 0.6-3.0 mL deionized water, 0.4-3.0 mL DNPH derivatization reagent and 50-500 µL HClO 4 Aqueous solution, shake well, place at room temperature for 30-150 min for derivatization reaction, add 50-500 µL pyridine after the reaction, add 100 µL internal standard working solution, and dilute to 10 mL with acetonitrile, shake well, pass through 0.22 µm organic phase filter membrane, into LC-MS / MS analysis.

[0041] Substituting the peak area ratio of the target substance and the internal standard quantitative ion pair into the regression equation, the acetaldehyde content in the sample was calculated to be 4.06 µg / g.

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Abstract

The invention relates to a method for rapid analysis determination of acetaldehyde in an electronic cigarette liquid, wherein the method comprises the following steps: firstly, adding a dispersing agent in an electronic cigarette liquid sample; then adding a DNPH derivatization reagent and an acidic solution, carrying out a derivatization reaction, and then adding an alkaline reagent and an internal standard substance; and finally analyzing and determining the content of acetaldehyde in the electronic cigarette liquid by using LC-MS / MS. The method has the advantages of high sensitivity, strong interference resistance, good repeatability, and simple and fast pretreatment process, and is suitable for detection of a large number of electronic cigarette liquid samples.

Description

technical field [0001] The invention relates to a rapid analysis and determination method for acetaldehyde in electronic cigarette liquid, belonging to the technical field of trace analysis. Background technique [0002] Acetaldehyde is a colorless liquid that flows easily at room temperature, has a pungent odor, is flammable and volatile. Acetaldehyde is slightly toxic, LD 50 1930 mg / kg (by mouth in rats); acute low concentration causes eye, nose and upper respiratory tract irritation symptoms and bronchitis; high concentration inhalation has anesthetic effect and can be fatal; chronic poisoning is similar to alcoholism, manifested as weight loss, anemia, Delirium, audiovisual hallucinations, intellectual loss, and mental disturbance. A large number of experimental results show that acetaldehyde is mutagenic. Current research results show that acetaldehyde is carcinogenic to experimental animals, but the evidence for human carcinogenicity is still insufficient. Therefore...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 潘立宁赵乐樊美娟刘克建陈黎余晶晶刘绍锋王冰贾云祯刘惠民孟庆华
Owner ZHENGZHOU TOBACCO RES INST OF CNTC
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