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A preparation method of photoelectrochemical furazolidone sensor based on bimetallic co-doped two-dimensional photosensitizer

A technology of furazolidone and photoelectrochemistry, which is applied in the field of preparation of photoelectrochemical furazolidone sensors, can solve the problems of low sensitivity of photoelectrochemical sensors, weakening of photoelectric signals, unfavorable practical applications, etc., and achieve broadening the range of photosensitive wavelengths, saving time, increasing The effect of photocatalytic activity

Inactive Publication Date: 2019-03-12
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In addition, the photogenerated electron-hole pairs of a single titanium dioxide nanomaterial are easy to recombine, which leads to the weakening of the photoelectric signal, and the poor conductivity of titanium dioxide also limits the sensitivity of photoelectrochemical sensors constructed from a single titanium dioxide nanomaterial. application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 FeMn-TiO 2 / MoS 2 preparation of

[0043] (1) Add 0.6 g of molybdenum disulfide powder, 0.2 mmol of iron salt and 0.2 mmol of manganese salt into 3 mL of n-butyllithium solution, and stir for 12 hours under nitrogen protection at 60 °C to obtain the reacted solution;

[0044] (2) Wash the reacted solution in step (1) with a non-polar solvent, and then perform ultrasonic treatment in a water bath at 60 °C. After the treatment, wash the treated solution with a non-polar solvent, and dry it in vacuum to obtain iron , Molybdenum disulfide nanomaterials co-intercalated with manganese;

[0045] (3) Add 500 mg of molybdenum disulfide nanomaterials co-intercalated with iron and manganese prepared in step (2) into 5 mL of tetrabutyl titanate, and after stirring for 1 hour, slowly add 0.5 mL of hydrofluoric acid while stirring acid, then reacted in a reactor at 160°C for 18 hours;

[0046] (4) The reaction product obtained in step (3) was centrifuged and washed thre...

Embodiment 2

[0052] Example 2 FeMn-TiO 2 / MoS 2 preparation of

[0053] (1) Add 0.6 g of molybdenum disulfide powder, 1.0 mmol of iron salt and 1.0 mmol of manganese salt into 5 mL of n-butyllithium solution, and stir for 24 hours under nitrogen protection at 30 °C to obtain the reacted solution;

[0054] (2) Wash the reacted solution in step (1) with a non-polar solvent, and then perform ultrasonic treatment in a water bath at 30 °C. After the treatment, wash the treated solution with a non-polar solvent, and dry it in vacuum to obtain iron , Molybdenum disulfide nanomaterials co-intercalated with manganese;

[0055] (3) Add 200 mg of molybdenum disulfide nanomaterials co-intercalated with iron and manganese prepared in step (2) into 5 mL of tetrabutyl titanate, stir for 1 hour, then slowly add 0.6 mL of hydrofluoric acid while stirring acid, then reacted in a reactor at 180°C for 20 hours;

[0056] (4) The reaction product obtained in step (3) was centrifuged and washed three times w...

Embodiment 3

[0062] The preparation method of embodiment 3 photoelectrochemical furazolidone sensor

[0063] (1) Use an ITO conductive glass with a width of 1 cm and a length of 4 cm as a working electrode, and drop-coat 8 µL of FeMn-TiO on the surface of the electrode 2 / MoS 2 Sol, dry at room temperature;

[0064] (2) Wash the electrode obtained in step (1) with the buffer solution PBS, continue to drop-coat 8 µL of 10 µg / mL furazolidone antibody solution on the surface of the electrode, and store it in a refrigerator at 4 °C to dry;

[0065] (3) Wash the electrode obtained in step (2) with PBS, continue to drip-coat 8 µL of bovine serum albumin solution with a concentration of 100 µg / mL on the surface of the electrode, and store it in a refrigerator at 4 °C to dry;

[0066] (4) Wash the electrode obtained in step (3) with PBS, continue to drip-coat 6 µL of alkaline phosphatase solution with a concentration of 20 µg / mL on the surface of the electrode, and store it in a refrigerator at ...

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Abstract

The invention discloses a preparation method of a photoelectrochemical furazolidone sensor. It belongs to the technical field of new nanometer functional materials and biosensors. The present invention firstly prepares a novel bimetallic co-doped two-dimensional photosensitizer, i.e. FeMn-TiO2 / MoS2, a two-dimensional nano-composite material FeMn-TiO2 / MoS2 in-situ compounded by iron and manganese co-doped titanium dioxide nano-squares and molybdenum disulfide. Good biocompatibility and large specific surface area, loaded with furazolidone antibody, immobilized with alkaline phosphatase, during detection, because alkaline phosphatase can catalyze L-ascorbic acid-2-phosphate trisodium salt AAP in situ Produce L-ascorbic acid AA, and then provide electron donors for photoelectric detection, and then use the specific quantitative combination of antibodies and antigens to affect the electron transport ability, so that the photocurrent intensity is correspondingly reduced, and finally realized the use of label-free photoelectrochemical methods Construction of a photosensor for the detection of furazolidone.

Description

technical field [0001] The invention relates to a preparation method of a photoelectrochemical furazolidone sensor. It belongs to the technical field of new nanometer functional materials and biosensors. Background technique [0002] Furazolidone (furazolidone) is a nitrofuran antibiotic, which is a broad-spectrum antibacterial drug. When used as a veterinary drug, furazolidone has good medicinal effects on the prevention and treatment of certain protozoan diseases, saprolegniasis, bacterial gill rot, red skin disease, and hemorrhagic diseases. In the breeding industry, furazolidone can be used to treat intestinal infections in livestock and poultry, such as piglet yellow and pullorum. In aquaculture, furazolidone has a certain effect on the infection of Myxosoma cerebri in Salmonidae. However, the Ministry of Agriculture of my country lists furazolidone as a prohibited drug and shall not be detected in animal food. FDA also banned the use of nitrofurans (including furaz...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/416G01N33/94G01N33/543
CPCG01N27/416G01N33/54386G01N33/9446
Inventor 张勇马洪敏杜斌胡丽华庞雪辉
Owner UNIV OF JINAN
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