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Tropane alkaloid microcapsule preparation and preparation method thereof

A tropane base and microcapsule technology is applied in the field of improvement of tropane base microcapsules, which can solve the problems of unsatisfactory medicinal effect in the field, difficult to control release rate, short duration of effect, etc., and achieves reduction of medication frequency and prevention and control cost. , the effect of prolonging the validity period

Inactive Publication Date: 2016-12-07
SHANDONG ACADEMY OF PESTICIDE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although there are reports on the preparation of microcapsules by in-situ polymerization or interfacial polymerization, there are generally problems such as difficulty in controlling the release rate and unsatisfactory drug efficacy in the field. Problems such as duration of validity are too short, the purpose of the present invention is exactly in order to coordinate the relationship between the two

Method used

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  • Tropane alkaloid microcapsule preparation and preparation method thereof
  • Tropane alkaloid microcapsule preparation and preparation method thereof
  • Tropane alkaloid microcapsule preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1, in-situ polymerization method 1.0% tropane base microcapsule suspension

[0040] (1) Preparation of urea-formaldehyde resin prepolymer aqueous solution: mix and dissolve 10 parts of urea and 24 parts of formaldehyde, add 42 parts of deionized water, adjust the pH to 8.0, and keep it at 70°C for 1 hour to obtain a mass fraction of 25% urea-formaldehyde resin Prepolymer (UF) solution.

[0041] (2) Dissolve 10 parts of tropane base crude oil in 5 parts of methyl oleate to obtain the capsule core oil phase, add it to 60 parts of UF aqueous solution (7%), add 4 parts of emulsifier PVA and 3 parts of dispersant NNO; 1000r / min stirring and dispersing into an O / W emulsion; slowly adjust the pH to 2.5 with 1moL / L HCl, then gradually raise the temperature to 60°C for 90min, and solidify into capsules. After reaching the end of the reaction, adjust the pH to ≈7 with sodium hydroxide.

[0042] Then add 5 parts of wetting agent NP-10, 5 parts of dispersant NNO and 4...

Embodiment 2

[0045] Example 2. In-situ polymerization method 0.5% tropane base multi-capsule wall thickness microcapsule suspension.

[0046] (1) Preparation of urea-formaldehyde resin prepolymer aqueous solution: mix and dissolve 10 parts of urea and 24 parts of formaldehyde, add 42 parts of deionized water, adjust the pH to 8.0, and keep it at 70°C for 1 hour to obtain a mass fraction of 25% urea-formaldehyde resin Prepolymer (UF) solution.

[0047] (2) Preparation of Tropane Microcapsules:

[0048] a: 5 parts of tropane base crude oil are dissolved in 3 parts of methyl oleate to obtain capsule core oil phase, join in 60 parts of 3% UF aqueous solution (3% refers to the mass fraction of urea-formaldehyde resin prepolymer UF, by step (1 ) obtained by diluting the 25% urea-formaldehyde resin prepolymer solution, the same below), adding 2 parts of emulsifier styrene-maleic anhydride and 1.5 parts of dispersant NNO; stirring and dispersing at 800r / min to form an O / W emulsion; Slowly adjust...

Embodiment 3

[0060] Example 3, in-situ polymerization method 1.0% tropane base multi-capsule wall thickness microcapsule suspension.

[0061] Method is the same as example 2, in the preparation process, 10 parts of tropane base crude oil are dissolved in 5 parts of methyl oleate, agent a: 60 parts of UF prepolymer (3%), 2.5 parts of emulsifier OP-10, dispersant lignin 1.5 parts of sodium sulfonate, stirred and dispersed at 1000r / min to form an O / W emulsion. Agent b: 60 parts of UF prepolymer (4%), 3 parts of emulsifier OP-10, 2 parts of dispersant sodium lignosulfonate, 1200r / min stirring and dispersing into O / W emulsion agent c: UF prepolymer ( 6%) 60 parts, 3.5 parts of emulsifier OP-10, 2 parts of dispersant sodium lignosulfonate, 1500r / min stirring and dispersing into O / W emulsion. Wall Thickness Microcapsule Suspension.

[0062] Its particle size and capsule wall thickness are shown in the table below:

[0063]

[0064]

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Abstract

The invention provides a tropane alkaloid microcapsule preparation and a preparation method thereof. Tropane alkaloid microcapsules are prepared by adopting an existing in-situ polymerization method or interfacial polymerization method; the tropane alkaloid microcapsules are blended according to a certain ratio to further prepare a microcapsule suspension agent; the releasing speeds of the microcapsules is controlled through different blending ratios; the preparation has a relatively high initial releasing speed and a long lasting period; and meanwhile, the tropane alkaloid microcapsule preparation has the advantages of high effective utilization rate of pesticides, environmental friendliness, small chemical injuries, reduction of leaching, small pollution to the environment and the like.

Description

technical field [0001] The invention belongs to the field of processing and application of pesticide formulations, and relates to the improvement technology of tropane base microcapsules. Background technique [0002] With the continuous expansion of the cultivated area of ​​vegetable protection, soil-borne nematode diseases, mainly root-knot nematodes, spread rapidly and become more and more serious, which has become a major obstacle to vegetable production in my country. However, most of the nematocides currently promoted are chemical pesticides with high toxicity, which not only pollutes vegetables, affects people's health, but also poses a potential threat to the environment. Tropolamine is an alkaloid nematocide extracted from Datura datura. It is not only effective in killing nematodes, but also has low toxicity and is safe for vegetables, so it has been widely used. [0003] At present, tropane base is mainly processed into emulsifiable concentrate for use in China. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/90A01N25/18A01N25/04A01P5/00
CPCA01N43/90A01N25/04A01N25/18
Inventor 庄占兴郭雯婷崔蕊蕊范金勇刘钰庄治国徐娜娜徐英王龙龙
Owner SHANDONG ACADEMY OF PESTICIDE SCI
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