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Auristilla used for treating chronic suppurative otitis media

A technology of suppurative otitis media and ear drops, applied in the direction of organic active ingredients, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of inability to quickly relieve the pain of patients and the long treatment period of traditional Chinese medicine decoctions , reduce the body's resistance and other problems, to achieve remarkable results, quick results, and the effect of removing corrupt substances

Inactive Publication Date: 2016-09-21
张金凤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are few medicines for the treatment of chronic suppurative otitis media. The main reason is that the curative effect is not significant. The medicines in the prior art are mainly based on western medicine anti-inflammatory and traditional Chinese medicine decoction oral administration. Western medicine anti-inflammatory mainly consists of oral or injection antibiotics. To reduce the body's resistance, the treatment cycle of traditional Chinese medicine decoction is too long and cannot quickly relieve the pain of patients. Therefore, the external application of ear drops for the clinical symptoms of chronic suppurative otitis media can quickly relieve the pain of patients, and at the same time clear up the purulent otitis media during the inflammatory attack period. Secretion; inhibit tympanic membrane perforation, promote tympanic membrane growth, thereby improving symptoms such as tinnitus and hearing loss in patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] An ear drop for treating chronic suppurative otitis media, the composition of which is: 1.2% cantharidin, 0.8% benzoic acid, 0.6% diclofenac sodium, 0.5% chrysin, 1.0% calcium phosphate, 0.5% antibacterial peptide, levulinic acid 0.2%, 0.05% borneol ketone, 1.3% isopropyl myristate, 0.3% vitamin C, 0.15% polyvinylpyrrolidone, 1.5% buffer, 0.1% stabilizer, 2.4% thickener, 0.5 pH adjuster %, the balance is water for injection.

[0022] Wherein, the antibacterial peptide is a bee venom antibacterial peptide, which not only has antibacterial and anti-inflammatory effects, but also has unique effects in antitumor and antiradiation, enhances immunity, and has a strong killing effect on bacteria in suppurative parts . Described buffer solution is acetate buffer solution, and its preparation method per 100ml is, after weighing 5.5g of sodium acetate and grinding and pulverizing, put it into a beaker, add 50ml of distilled water and stir to make it fully dissolve, adjust with g...

Embodiment 2

[0029] An ear drop for treating chronic suppurative otitis media, the composition of which is: 1.5% cantharidin, 1.2% benzoic acid, 0.8% diclofenac sodium, 0.7% chrysin, 1.2% calcium phosphate, 0.65% antibacterial peptide, levulinic acid 0.3%, 0.1% borneol ketone, 1.4% isopropyl myristate, 0.4% vitamin C, 0.25% polyvinylpyrrolidone, 2.5% buffer, 0.25% stabilizer, 3.6% thickener, pH adjuster 1.5 %, the balance is water for injection.

[0030]Wherein, the antibacterial peptide is a bee venom antibacterial peptide, which not only has antibacterial and anti-inflammatory effects, but also has unique effects in antitumor and antiradiation, enhances immunity, and has a strong killing effect on bacteria in suppurative parts . Described buffer solution is acetate buffer solution, and its preparation method per 100ml is, after weighing 5.5g of sodium acetate and grinding and pulverizing, put it into a beaker, add 50ml of distilled water and stir to make it fully dissolve, adjust with g...

Embodiment 3

[0037] An ear drop for treating chronic suppurative otitis media, the composition of which is: cantharidin 1.8%, benzoic acid 1.6%, diclofenac sodium 1.0%, chrysin 0.9%, calcium phosphate 1.4%, antibacterial peptide 0.8%, levulinic acid 0.4%, 0.15% borneol ketone, 1.5% isopropyl myristate, 0.5% vitamin C, 0.35% polyvinylpyrrolidone, 3.5% buffer, 0.4% stabilizer, 4.8% thickener, pH adjuster 2.5 %, the balance is water for injection.

[0038] Wherein, the antibacterial peptide is a bee venom antibacterial peptide, which not only has antibacterial and anti-inflammatory effects, but also has unique effects in antitumor and antiradiation, enhances immunity, and has a strong killing effect on bacteria in suppurative parts . Described buffer solution is acetate buffer solution, and its preparation method per 100ml is, after weighing 5.5g of sodium acetate and grinding and pulverizing, put it into a beaker, add 50ml of distilled water and stir to make it fully dissolve, adjust with g...

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Abstract

The invention discloses an auristilla used for treating chronic suppurative otitis media. The auristilla is prepared from: cantharidin 1.2-1.8%, benzoic acid 0.8-1.6%, diclofenac sodium 0.6-1.0%, chrysin 0.5-0.9%, calcium phosphate 1.0-1.4%, antimicrobial peptide 0.5-0.8%, levulinic acid 0.2-0.4%, dipterocarpol 0.05-0.15%, isopropyl myristate 1.3-1.5%, vitamin C 0.3-0.5%, polyvinylpyrrolidone 0.15-0.35%, acetate buffer solution 1.5-3.5%, stabilizer 0.1-0.4%, tackifier 2.4-4.8%, pH modifier 0.5-2.5%, and the balance water for injection. The medicine of the invention has good antiseptic, antiphlogistic, and antipruritic effects, is used for the patients of the chronic suppurative otitis media, can promote pus fading and absorption, can repair the symptom of tympanic membrane perforation, can recover the hearing to be normal, has rapid and outstanding effect and high recovery rate, has high total effective rate for treating chronic suppurative otitis media, and can be promoted and used widely in clinical practice.

Description

technical field [0001] The invention relates to the technical field of medication for five sense organs diseases, in particular to an ear drop for treating chronic suppurative otitis media. Background technique [0002] Chronic suppurative otitis media is a clinically common ear disease. The main clinical symptoms are intermittent or continuous pus discharge in the ear, perforation of the tympanic membrane, and hearing loss as the main clinical manifestations. In severe cases, it can cause intracranial and extracranial complications. , the main cause is chronic suppurative inflammation of the middle ear mucosa, periosteum or deep bone, often coexisting with chronic mastoiditis. Mostly due to delayed treatment or improper treatment of acute suppurative otitis media, prolonged chronic, or direct continuation of acute necrotizing otitis media. The presence of chronic lesions in the nose and pharynx is also an important reason. Generally, 6 to 8 weeks after the start of acute ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/02A61K9/08A61K47/12A61K47/32A61K47/38A61K47/36A61P27/16A61P31/04A61K31/196
CPCA61K9/0046A61K9/08A61K31/196A61K38/02A61K47/12A61K47/32A61K47/36A61K47/38A61K2300/00
Inventor 张金凤
Owner 张金凤
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