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Breathable and hemostatic alginate dressing and preparation method thereof

A technology of alginate and potassium alginate, which is applied in the field of medical materials, can solve the problems of unfavorable wound healing, poor air permeability, secondary infection, etc., and achieve the effect of improving water vapor transmission rate and hemostatic water vapor transmission rate

Inactive Publication Date: 2016-08-17
SUZHOU COSMETIC MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The Chinese patent with the application number 201310547279.0 discloses a preparation method of wound hemostatic dressing. Although the hemostatic effect of the prepared dressing is good, the air permeability is poor, and the wound surface is prone to secondary infection, causing bacteria to multiply in the wound, which is not conducive to the wound the healing

Method used

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  • Breathable and hemostatic alginate dressing and preparation method thereof

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Effect test

Embodiment 1

[0017] A breathable hemostatic alginate dressing, consisting of the following components by mass: 46 parts of potassium alginate, 15 parts of carboxymethyl chitosan, 3 parts of ammonium dihydrogen phosphate, 2 parts of hydrogenated lecithin, polyethylene 8 parts alcohol, 6 parts sorbitol, 3 parts acetyl tributyl citrate, 15 parts butanediol, 2 parts sodium hyaluronate, 5 parts licorice extract.

[0018] Preparation:

[0019] (1) In parts by weight, potassium alginate, carboxymethyl chitosan and butanediol were mixed, and ultrasonicated at 50° C. for 20 minutes to obtain mixture 1;

[0020] (2) Add ammonium dihydrogen phosphate, hydrogenated lecithin, polyvinyl alcohol, sorbitol, acetyl tributyl citrate, sodium hyaluronate, and licorice extract to mixture 1, heat to 70°C, and stir evenly. Insulate for 10 minutes, and obtain mixture 2 after cooling to room temperature;

[0021] (3) Soak the degreasing gauze in the mixture 2, dry in a dryer, seal, pack, and sterilize with ultra...

Embodiment 2

[0023] A breathable hemostatic alginate dressing, which consists of the following components in parts by mass: 62 parts of potassium alginate, 29 parts of carboxymethyl chitosan, 12 parts of ammonium dihydrogen phosphate, 12 parts of hydrogenated lecithin, polyethylene 21 parts of alcohol, 17 parts of sorbitol, 9 parts of acetyl tributyl citrate, 24 parts of butanediol, 10 parts of sodium hyaluronate, 13 parts of licorice extract.

[0024] Preparation:

[0025] (1) In parts by weight, potassium alginate, carboxymethyl chitosan and butanediol were mixed, and ultrasonicated at 90° C. for 40 minutes to obtain mixture 1;

[0026] (2) Add ammonium dihydrogen phosphate, hydrogenated lecithin, polyvinyl alcohol, sorbitol, acetyl tributyl citrate, sodium hyaluronate, and licorice extract to mixture 1, heat to 120°C, and stir evenly. Insulate for 20min, and obtain mixture 2 after cooling to room temperature;

[0027] (3) Soak the degreasing gauze in the mixture 2, dry in a dryer, sea...

Embodiment 3

[0029] A breathable hemostatic alginate dressing, consisting of the following components by mass: 49 parts of potassium alginate, 17 parts of carboxymethyl chitosan, 5 parts of ammonium dihydrogen phosphate, 4 parts of hydrogenated lecithin, polyethylene Alcohol 11 parts, sorbitol 9 parts, acetyl tributyl citrate 4 parts, butylene glycol 17 parts, sodium hyaluronate 4 parts, licorice extract 8 parts.

[0030] Preparation:

[0031] (1) In parts by weight, potassium alginate, carboxymethyl chitosan and butanediol were mixed, and ultrasonicated at 60° C. for 25 minutes to obtain mixture 1;

[0032] (2) Add ammonium dihydrogen phosphate, hydrogenated lecithin, polyvinyl alcohol, sorbitol, acetyl tributyl citrate, sodium hyaluronate, and licorice extract to mixture 1, heat to 80°C, and stir evenly. Insulate for 15 minutes, and obtain mixture 2 after cooling to room temperature;

[0033] (3) Soak the degreasing gauze in the mixture 2, dry in a dryer, seal, pack, and sterilize with...

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Abstract

The invention discloses a breathable hemostatic alginate dressing and a preparation method thereof. The dressing consists of the following components in parts by mass: 46-62 parts of potassium alginate, 15-29 parts of carboxymethyl chitosan, phosphoric acid 3‑12 parts of ammonium dihydrogen, 2‑12 parts of hydrogenated lecithin, 8‑21 parts of polyvinyl alcohol, 6‑17 parts of sorbitol, 3‑9 parts of acetyl tributyl citrate, 15‑24 parts of butylene glycol , 2‑10 parts of sodium hyaluronate, 5‑13 parts of licorice extract. The preparation method is as follows: mix potassium alginate, carboxymethyl chitosan and butanediol, and ultrasonicate; then add the remaining components, mix, heat, stir evenly, keep warm, and cool to room temperature; soak degreasing gauze in it, dry Machine dried, sealed, packaged and sterilized by ultraviolet light. The dressing prepared by the invention achieves the effect of hemostasis and improvement of water vapor transmission rate through the synergistic effect of the components, and can be widely used for wound healing.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to a breathable hemostatic alginate dressing and a preparation method thereof. Background technique [0002] Dressing refers to the auxiliary materials used in addition to the main material of the article. An important function of modern wound dressing is that it replaces the important function of damaged skin and continues to heal the wound and skin lesions. It protects against mechanical factors (e.g. dirt, impact, inflammation, etc.), against pollution and chemical stimuli; against secondary infection; against desiccation and loss of body fluids (electrolyte loss); against heat loss; actively affects the wound healing process through debridement, Create a microenvironment that promotes wound healing. [0003] The ingredient of alginate medical dressing is alginate, which is a natural polysaccharide carbohydrate extracted from seaweed. Moisten the environment, promote wound heal...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/18A61L15/20A61L15/24A61L15/44
CPCA61L15/28A61L15/18A61L15/20A61L15/24A61L15/44A61L2300/112A61L2300/232A61L2300/30A61L2300/412A61L2400/04
Inventor 喻国贞金仲恩欧阳智琨
Owner SUZHOU COSMETIC MATERIALS
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