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Chinese astilbe herb ultra-fine powder decoction pieces and preparation method thereof

A technology of ultra-fine powder and ultra-fine powder for women is applied in powder delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve the problems of inconvenience in taking, low transfer rate of active ingredients, and easy destruction of active ingredients when heated. To achieve the effect of improving labor pain, improving bioavailability and reducing drug use

Inactive Publication Date: 2016-06-29
建德市大洋南山中药材专业合作社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the traditional decoction pieces used in clinical practice are mainly Astilbee slices and Astilbee regular powder, etc. Traditional decoction pieces have problems such as low transfer rate of active ingredients, inconvenient taking, and some active ingredients are easily destroyed by heating.

Method used

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  • Chinese astilbe herb ultra-fine powder decoction pieces and preparation method thereof
  • Chinese astilbe herb ultra-fine powder decoction pieces and preparation method thereof
  • Chinese astilbe herb ultra-fine powder decoction pieces and preparation method thereof

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preparation example Construction

[0032] The invention provides a preparation method of astilbeia superfine powder decoction pieces, comprising the following steps:

[0033] 1) Pulverizing and sieving the Astilbee decoction pieces to obtain the above-sieve component and the under-sieve component;

[0034] 2) Superfinely pulverizing the under-sieve component obtained in the step 1) to obtain superfine powder of astilbee, the particle diameter of the superfine powder of astilbee ≤ 75 μm;

[0035] 3) mixing the superfine powder of astilbee obtained in the step 2) with auxiliary materials to obtain decoction pieces of superfine powder of astilbee.

[0036] The present invention adopts the technical solution for preparing astilbee superfine powder described in the above technical solution to prepare astilaginum superfine powder, which will not be repeated here.

[0037] After the superfine astilbe powder is obtained, the present invention mixes the superfine astilbe powder with auxiliary materials to obtain decoct...

Embodiment 1

[0050] First remove the silt, impurities, and non-medicinal parts of astilbee medicinal materials to obtain astilbee roots and rhizomes; then cut the washed astilbee roots and rhizomes into 3mm thick slices to obtain astilbee decoction pieces , using a continuous feeding pulverizer to pulverize Astilbee decoction pieces for 5 minutes, screen with 24 meshes, and pulverize the under-sieve components that can pass through the sieve holes with an ultrafine pulverizer, using airflow pulverization, the grinding pressure is 0.8Mpa, and the speed of the classifying wheel is 0.8Mpa. 5500rpm, the pulverization time is 3h, and pulverized into a powder with a particle size of ≤75 μm to obtain astilbe superfine powder;

[0051] Astilbee superfine powder is mixed with dextrin and starch in a mass ratio of 1:10:10 to obtain wet material;

[0052] Put the obtained wet material into the drying tray of the oven to dry, the thickness of the wet material in each baking tray is 2cm, the oven tempe...

Embodiment 2

[0054] First remove the silt, impurities, and non-medicinal parts of astilbee medicinal materials to obtain astilbee roots and rhizomes; then cut the washed astilbee roots and rhizomes into 3mm thick slices to obtain astilbee decoction pieces , using a continuous feeding pulverizer to pulverize Astilbee decoction pieces for 5 minutes, screen with 24 meshes, pulverize the sub-screen components that can pass through the sieve holes with a superfine pulverizer, and pulverize with a ball mill. The ball-to-material ratio is 10:1. The diameter is 0.5cm, the crushing time is 15h, and the rotating speed is 400rpm, and it is crushed into a powder with a particle size of ≤75 μm to obtain superfine powder of astilbe; all the components on the sieve that cannot pass through a 24-mesh sieve are mixed with 7 times the amount of 55% ethanol Extract the aqueous solution for 3 times to obtain the extract, use a rotary evaporator to concentrate the obtained extract at -0.1MPa, 55°C under reduced...

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Abstract

The invention provides Chinese astilbe herb ultra-fine powder decoction pieces which comprise Chinese astilbe herb ultra-fine powder and auxiliaries, and the particle size of the Chinese astilbe herb ultra-fine powder is smaller than or equal to 75 microns.The invention further provides a preparation method of the Chinese astilbe herb ultra-fine powder decoction pieces.The method includes the steps that 1, the Chinese astilbe herb decoction pieces are crushed and sieved, and a Chinese astilbe herb plus sieve component and a Chinese astilbe herb minus sieve component are obtained; 2, the obtained minus sieve component is subjected to superfine grinding, and the Chinese astilbe herb ultra-fine powder is obtained; 3, the Chinese astilbe herb ultra-fine powder is mixed with the auxiliaries, and the Chinese astilbe herb ultra-fine powder decoction pieces are obtained.According to the Chinese astilbe herb ultra-fine powder decoction pieces, the dissolution rate of the effective ingredient bergenin in Chinese astilbe herb ultra-fine powder particles is remarkably improved, the dissolution rate can reach 35.12 mg / g to the maximum, the problem that it is difficult to transfer main ingredients, particularly the bergenin in Chinese astilbe herbs is solved, and thus bioavailability of medical materials is improved.

Description

technical field [0001] The invention belongs to the technical field of medicines and health care products, and in particular relates to superfine powder decoction pieces of astilbee. Background technique [0002] Astilbe, also known as red cohosh, yin and yang tiger, golden hair notoginseng, etc., is the dry rhizome of Astilbechinensis (Maxim.) Franch.et.Sav. or AstilbegrandisStapfexWils. Astilbe is a traditional local medicinal material in Zhejiang Province and a characteristic medicinal material of ethnic minorities. It is now recorded in "Zhejiang Province Traditional Chinese Medicine Processing Standards" 2015 edition. It is mainly used to treat bruises, rheumatic arthralgia, snake bites, anti-tumor, cold, stomach pain, enteritis, chronic bronchitis, convulsions in children, and various malignant tumors. [0003] Modern pharmacological studies have shown that Astilbee has analgesic, anti-inflammatory, antibacterial, and anti-endotoxin effects; the results of in vitro an...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/14A61P29/00A61P35/00
Inventor 吴国清戴纯辉
Owner 建德市大洋南山中药材专业合作社
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