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Attapulgite containing pharmaceutical composition for preventing and treating chicken coccidiosis and preparation thereof

A chicken coccidiosis and composition technology, which is applied in the field of drug combination of zinc-chromium-loaded attapulgite clay and diclazuril, can solve the problems of drug residues, poor effect of anticoccidial drugs, and extensive drug resistance. Achieve the effects of slowing down the decline in weight gain, reducing the amount of chicken bloody feces, and reducing drug resistance problems

Active Publication Date: 2016-06-29
GUANGZHOU GREAT BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a pharmaceutical composition for preventing coccidiosis in chickens, aiming at problems such as poor clinical effect of anticoccidiostats, extensive drug resistance, and drug residues.

Method used

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  • Attapulgite containing pharmaceutical composition for preventing and treating chicken coccidiosis and preparation thereof
  • Attapulgite containing pharmaceutical composition for preventing and treating chicken coccidiosis and preparation thereof
  • Attapulgite containing pharmaceutical composition for preventing and treating chicken coccidiosis and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: Preparation of zinc-chromium-loaded attapulgite clay

[0022] Add 100 g of attapulgite clay to 1 L of a solution containing zinc chloride (1 mol / L) and chromium trichloride (0.05 mol / L), react for 4 h at 55 °C under water bath shaking conditions, wash with deionized water 3 times, 105 Dry in a drying oven at ℃ to constant weight, grind, and pass through a 200-mesh sieve to obtain zinc-chromium-loaded attapulgite clay. Weigh 0.1g of zinc-chromium-loaded attapulgite clay, add 7mL of 65%-68% concentrated nitric acid, 3mL of 36%-38% concentrated hydrochloric acid, and 3mL of 30% hydrogen peroxide. Microwave digestion in microwave digestion apparatus for 30min. All the digested solution after digestion was transferred to a 25mL volumetric flask, and the volume was adjusted to 25mL with ultrapure water. The inductively coupled plasma emission spectrometer was used for detection, and single-element zinc and chromium standard solutions were configured to draw a ...

Embodiment 2

[0023] Embodiment 2: the preparation of the pharmaceutical composition of preventing and treating chicken coccidiosis

[0024] The pharmaceutical composition for preventing and treating chicken coccidiosis comprises attapulgite clay loaded with zinc and chromium and the anticoccidial drug diclazuril, which are uniformly mixed in a mass ratio of 1:1.

Embodiment 3

[0025] Embodiment 3: the preventive effect of zinc-chromium-loaded attapulgite clay on chicken coccidiosis

[0026] In large-scale chicken farms, when the chickens were 12 days old, 600 chickens were randomly selected, divided into 4 groups, 150 chickens in each group, and each group was separately caged and fed. The first group: add 5g of zinc-chromium-loaded attapulgite clay per kilogram of feed; the second group: add 10g of zinc-chromium-loaded attapulgite clay per kilogram of feed; the third group: add 15g of zinc-chromium-loaded attapulgite clay per kilogram of feed ; The fourth group (blank group): normal feed. Observe the mental state of the chickens in each group every day, and count whether there is blood in the stool. If there is blood in the stool, use the saturated saline flotation method to check whether you can see coccidia oocysts. If there are coccidia oocysts, it can be confirmed as coccidia infection .

[0027] According to the observation results, the onse...

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Abstract

The invention provides a pharmaceutical composition for preventing and treating chicken coccidiosis. The pharmaceutical composition is prepared from 50% of attapulgite clay carrying zinc and chromium and 50% of diclazuril. The attapulgite clay carrying zinc and chromium is prepared through the method which includes the steps that 100 g / L attapulgite clay is added to a solution containing zinc ions and chromium ions, a reaction is conducted for 4 h under the vibration condition of a 55-DEG C water bath, washing is conducted three times with deionized water, drying is conducted in a 105-DEG C drying box till constant weight is achieved, grinding is conducted, and the attapulgite clay carrying zinc and chromium is obtained after the attapulgite clay passes through a 200-mesh screen. According to the pharmaceutical composition for preventing and treating chicken coccidiosis, the amount of chicken bloody stool can be effectively reduced, the discharge quantity of excrement oocysts is reduced, weight gain decline caused by coccidium infection is retarded, hurt of chicken coccidian to chicken intestinal tracts can be relieved, the resistance of intestinal mucosa is enhanced, and a good effect is achieved for preventing and treating chicken coccidiosis; meanwhile, the use amount of coccidium resisting chemical drugs can be reduced, drug residues are reduced, and drug resistance problems are relieved.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating chicken coccidiosis and a preparation method thereof, in particular to a pharmaceutical combination of zinc-chromium-loaded attapulgite clay and diclazuril that can effectively prevent and treat chicken coccidiosis, belonging to feed Additive field. Background technique [0002] Chicken coccidiosis is a common chicken parasitic disease, often showing an outbreak trend. Chicken coccidia mainly parasitize in the intestinal tract of chicks, causing intestinal hemorrhage and necrosis, and the weight gain and egg production of chicks after the infection is cured are also significantly affected, which brings serious economic losses to the chicken industry. According to the life history and transmission characteristics of chicken coccidiosis, the ideas of preventing and controlling chicken coccidiosis are mainly two aspects: inhibiting insecticides in vivo and in vitro and enha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/30A61P33/02A23K50/75A23K20/20A23K20/28A23K20/195A61K31/53A61K33/24A61K33/06
CPCA61K31/53A61K33/06A61K33/24A61K33/30A61K2300/00
Inventor 魏平华杨德吉姚大伟
Owner GUANGZHOU GREAT BIOLOGICAL TECH
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