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Preparation method for degradable suture line

A suture thread and polycaprolactone technology, applied in the textile field, can solve problems such as poor hydrophilicity and slow degradation, achieve high-tech content, promote industrial upgrading, and promote the effect of enterprises creating income

Inactive Publication Date: 2016-06-01
广东省揭阳市质量计量监督检测所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Polycaprolactone (PCL) has been proven to have good tissue compatibility, biodegradability, and easy plasticity, and is widely used in medical sutures, biological scaffold materials, etc., but it has disadvantages such as slow degradation and poor hydrophilicity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1, The preparation, performance research and determination of the optimal blending ratio of a polycaprolactone / polyvinylpyrrolidone (PCL / PVP) blend material for preparing degradable sutures include the following steps:

[0016] A, the preparation of polycaprolactone / polyvinylpyrrolidone blend material: weigh polycaprolactone, polyvinylpyrrolidone total mass 4g, dissolve in the dichloromethane solvent of 40g (the mass fraction of PVP is respectively: 0, 15%, 20%, 25%, 30%, 35%, 40%, correspondingly, the quality fractions of PCL are: 100%, 85%, 80%, 75%, 70%, 65%, 60% ); Stir at room temperature until clarification; then cast the prepared solution on a glass plate, and form a film after the dichloromethane solution evaporates; finally vacuum-dry at 40°C to constant weight;

[0017] B. Research on the properties of polycaprolactone / polyvinylpyrrolidone blended materials: mechanical properties research: cut the blended film prepared in A into 5mm×60mm samples, a...

Embodiment 2

[0019] Embodiment 2, A kind of preparation method of degradable suture thread, the polycaprolactone PCL / polyvinylpyrrolidone PVP blend material that weight ratio is 80:20 and methylene chloride are dissolved into the spinning stock solution that concentration is 25-28wt%, spinning The silk stock solution is spun through a small dry spinning machine; the filaments are ejected from the spinneret into the spinning tunnel, and through the action of the hot air flow in the tunnel, the solvent in the stock solution stream is quickly volatilized to obtain unshaped primary Then, the unshaped as-spun silk was stretched 5 times at room temperature, and then stretched 1.2 times at 50°C, and then heat-set at 50°C for 10 hours under the protection of nitrogen to obtain a suture with a diameter of 0.25mm. According to the test of the standard GB / T14344-2008 "Test Method for Tensile Properties of Chemical Fiber Filament", the suture produced by it has a straight tensile breaking strength > ...

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PUM

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Abstract

The invention relates to a preparation method for a degradable suture line, in particular to a preparation method for a degradable suture line containing polycaprolactone. According to the method, polycaprolactone (PCL) / polyvinyl pyrrolidone (PVP) blended materials and an organic solvent are dissolved into a spinning solution, and the suture line with good mechanical performance, good tissue compatibility and bio-degradable performance is obtained through dry spinning and a multi-step drafting and heat setting method. Due to the fact that PVP is added to PCL, PVP is important water-soluble polymer and has excellent hydrophilia and biocompatibility, through blending of PVP and PCL, hydrophilia of PCL can be improved, the dilution effect is achieved for the degree of crystallinity of PCL, and the degradation speed of PLC is changed accordingly. The biomedical suture line prepared from the PCL / PVP blended materials has good mechanical performance and tissue compatibility, and the degradation speed of the suture line can also better meet actual demands.

Description

technical field [0001] The invention belongs to the technical field of textiles, and in particular relates to a preparation method of a degradable suture, especially a preparation method of a degradable suture containing polycaprolactone. Background technique [0002] Surgical suture is a sterile thread used for wound closure, tissue ligation and fixation. Non-biodegradable sutures cannot be absorbed by the body, and there are different degrees of tissue reactions. The sutured epidermis, especially the local skin, will leave scars; while biodegradable sutures are easily absorbed or excreted after degradation in body tissues, avoiding secondary The pain caused by the first operation reduces the chance of wound infection and the scar is small. Therefore, biodegradable medical sutures have attracted more and more attention. [0003] Polycaprolactone (PCL) has been proven to have good tissue compatibility, biodegradability, and easy plasticity, and is widely used in medical su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F8/14D01F8/10A61L17/10
CPCD01F8/14A61L17/10A61L17/105D01F8/10
Inventor 江创生陈向标赖明河罗永文
Owner 广东省揭阳市质量计量监督检测所
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