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Chlorin e6 effective for treatment, prevention or improvement of acne

A technology of chlorin and acne, applied in the direction of medical preparations containing active ingredients, organic chemistry, organic active ingredients, etc., can solve the problem that the antibacterial activity of Propionibacterium acnes has not been reported yet

Active Publication Date: 2016-04-06
DONG SUNG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the excellent antibacterial activity of chlorin e6 against P. acnes has not been reported

Method used

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  • Chlorin e6 effective for treatment, prevention or improvement of acne
  • Chlorin e6 effective for treatment, prevention or improvement of acne
  • Chlorin e6 effective for treatment, prevention or improvement of acne

Examples

Experimental program
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Effect test

preparation example Construction

[0022] 1. Preparation of pharmaceutical composition

[0023] In addition to chlorin e6 as the active ingredient, the pharmaceutical composition of the present invention can be made into a preparation for external use by further comprising a suitable carrier, excipient or diluent commonly used in the pharmaceutical field, such as liquid, Suspensions, ointments, patches, sprays, etc. Carriers, excipients or diluents that may be included in the compositions of the present invention may be, for example, lactose, glucose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, gum arabic , Alginate, Gelatin, Calcium Phosphate, Calcium Silicate, Cellulose, Methylcellulose, Microcrystalline Cellulose, Polyvinylpyrrolidone, Water, Methylparaben, Propylparaben, Talc, Magnesium Stearate and Mineral Oil. Pharmaceutical compositions can be prepared by using commonly used diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrants, surfactants an...

Embodiment 1

[0031] Example 1. Antibacterial effect against Propionibacterium acnes (Propionibacteriumacnes, KCTC3314)

[0032]P. acnes is a bacterium that lives mainly around the pores or in the infundibulum of the hair follicle. It feeds primarily on sebum, degrading the major components of sebum (ie, triglycerides) into fatty acids and glycerol. The free fatty acids produced severely irritate the skin, causing inflammation of the follicle wall or cells surrounding the pore. When treated at a concentration of 200 μΜ under dark conditions, chlorin e6 inhibited the growth of P. acnes by about 50% compared to the untreated control. As a result, only about 50% of the bacteria can proliferate. In contrast, 5-ALA inhibited the growth of bacteria by about 25% under the same conditions, and about 85% of bacteria could proliferate. When a halogen lamp was used to irradiate P. acnes with light of 3,000 Lux for 1 hour, chlorin e6 inhibited about 45% of the bacterial growth at a concentration of ...

Embodiment 2

[0034] Example 2. Antibacterial effect against Staphylococcus aureus (Staphylococcusaureus)

[0035] Staphylococcus aureus is a bacterium associated with sepsis, intestinal infections, skin infections, and joint infections. It can spread through contaminated hands, eyes or skin and can cause inflammation or food poisoning. Recently, antibiotic-resistant Staphylococcus aureus has been found. figure 2 Shown are the results of assaying the antibacterial effects of chlorin e6 and 5-ALA against Staphylococcus aureus. Under dark conditions, chlorin e6 inhibited the growth of Staphylococcus aureus by about 35% at a concentration of 100 μM compared to the control group. Under the same conditions, 5-ALA inhibited the growth of bacteria by about 10%. When irradiated with 3000 Lux of light for 1 hour, chlorin e6 at a concentration of 12.5 μM inhibited about 45% of the bacterial growth, and only about 55% of the bacteria could proliferate. In contrast, 5-ALA inhibited about 20% of ba...

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Abstract

The present invention relates to a pharmaceutical composition or a cosmetic composition, comprising, as an active ingredient, chlorin e6 having excellent antibacterial activity against Propionibacterium acnes.

Description

technical field [0001] The present invention relates to a pharmaceutical or cosmetic composition containing chlorin e6, which has excellent antibacterial activity against Propionibacterium acnes, as an active ingredient. Background technique [0002] The skin plays an important role in protecting the human body from the external environment. Various bacteria colonize the skin and cause many skin diseases. Acne is the most representative disease. The word acne is derived from the Greek word "akme", which means "spot". Although acne most commonly appears during adolescence, it has recently also appeared in a wide range of age groups due to air pollution, substance abuse, etc. Acne occurs in certain conditions in which oil glands called sebaceous glands attached to the hair follicles overproduce sebum, which, along with dead skin cells, clogs the follicles. As sebum and other impurities become trapped in hair follicles, they become lumps, or develop inflammation as bacteria...

Claims

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Application Information

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IPC IPC(8): A61K31/409A61P17/00
CPCA61K31/409A61K41/0071A61P17/00A61P17/10A61P43/00A61K8/30A61K9/08A61Q17/00C07D487/22
Inventor 罗圭焕李美荣天性南李欢锡全范洙全裕美韩忠燮
Owner DONG SUNG PHARMA CO LTD
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