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Polyethylene glycol modified Bi nano photothermal conversion material as well as preparation method and application thereof

A photothermal conversion material, polyethylene glycol technology, applied in the field of biomedicine, can solve the problems of complex synthesis process, photothermal conversion performance, photothermal stability and biological safety to be improved, and achieves low cytotoxicity, ideal Photothermal treatment effect, strong absorption effect

Active Publication Date: 2016-03-23
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention is to solve the problem of existing developed inorganic light-to-heat conversion materials (such as gold nanorods, gold nanoshells, carbon nanotubes, Cu 9 S 5 Nanocrystals, etc.) photothermal conversion performance, photothermal stability and biological safety need to be improved, and the synthesis process is relatively complicated, and a polyethylene glycol-modified bismuth nano photothermal conversion material, its preparation method and application

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  • Polyethylene glycol modified Bi nano photothermal conversion material as well as preparation method and application thereof
  • Polyethylene glycol modified Bi nano photothermal conversion material as well as preparation method and application thereof
  • Polyethylene glycol modified Bi nano photothermal conversion material as well as preparation method and application thereof

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specific Embodiment approach 1

[0028] Specific Embodiment 1: In this embodiment, a polyethylene glycol-modified bismuth nano-photothermal conversion material is prepared from surfactants, bismuth salts, polypropylene amine hydrochloride aqueous solution, polyacrylic acid aqueous solution and cross-linking agent. The particle size of the polyethylene glycol-modified bismuth nano-photothermal conversion material is 20nm to 200nm, and the photothermal conversion efficiency of the polyethylene glycol-modified bismuth nano-photothermal conversion material is 25% to 35%. .

[0029] The preparation of the polyethylene glycol-modified bismuth nano-photothermal conversion material described in this embodiment is carried out according to the following steps:

[0030] 1. Add the surfactant into the solvent, mix uniformly under the condition of mechanical stirring, then add bismuth salt to it, continue stirring and mixing uniformly to obtain a reaction mixture, and heat the reaction mixture from room temperature to 50°C ...

specific Embodiment approach 2

[0033] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the surfactant is one of α-D-glucose, maltose, ribose and polyvinylpyrrolidone PVP or a mixture of several of them; The solvent is one or a mixture of several of 1,2-propanediol, ethylene glycol and water; the bismuth salt is one or a mixture of several of bismuth nitrate, bismuth acetate and bismuth chloride; the reduction The agent is one of morpholine borane solution, sodium borohydride solution and hydroxylamine solution or a mixture of several of them; the concentration of the reducing agent is (10-40) mg / mL; the crosslinking agent A is 1 -(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride solution and a mixture of one or both of glutaraldehyde solutions; the cross-linking agent B is 1-(3- One or a mixture of dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride solution and glutaraldehyde solution. Others are the same as the first embodiment.

specific Embodiment approach 3

[0034] Specific embodiment three: In this embodiment, a method for preparing a polyethylene glycol-modified bismuth nano-photothermal conversion material is carried out according to the following steps:

[0035] 1. Add the surfactant into the solvent, mix uniformly under the condition of mechanical stirring, then add bismuth salt to it, continue stirring and mixing uniformly to obtain a reaction mixture, and heat the reaction mixture from room temperature to 50°C to 150°C. Add a reducing agent to the reaction mixture under the condition of 50°C-150°C, react for 0.5min-5min, put it in an ice bath to cool to room temperature after the reaction, centrifuge and wash 1-5 times, collect samples and freeze-dry to obtain bismuth Nanoparticle material; the mass ratio of the bismuth salt to the surfactant is 1:(10~30); the volume ratio of the mass of the bismuth salt to the solvent is 1g:(150~250) mL; the reaction mixture and The volume ratio of the reducing agent is 1:(0.1~0.2);

[00...

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Abstract

The invention relates to the field of biomedicine, particularly to a polyethylene glycol modified Bi nano photothermal conversion material as well as a preparation method and an application thereof, and aims to solve problems that photothermal conversion performance, photothermal stability and biosecurity of existing developed inorganic photothermal conversion materials (such as gold nano-rods, gold nano-shells, carbon nano-tubes, Cu9S5 nanocrystals and the like) need to be improved and synthetic processes are relatively complex. The particle size of the polyethylene glycol modified Bi nano photothermal conversion material is 20-200 nm, and the photothermal conversion efficiency of the polyethylene glycol modified Bi nano photothermal conversion material is 25%-35%. The method comprises steps as follows: I, a Bi nanoparticle material is prepared; II, the Bi nanoparticle material is coated. The polyethylene glycol modified Bi nano photothermal conversion material as a photothermal conversion nanomaterial is used for photothermal therapy of malignant tumors.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a polyethylene glycol-modified bismuth nano-photothermal conversion material, its preparation method and application. Background technique [0002] With the acceleration of people's life rhythm, the increase of pressure and the increasing pollution of the natural environment, the incidence of malignant tumors (cancer) is increasing year by year, which seriously threatens the life and health of human beings. At present, conventional cancer treatment methods mainly include surgical resection, drug chemotherapy, and physical radiation therapy. Although they all have certain therapeutic effects, they have inherent limitations in the actual clinical treatment of cancer (especially advanced cancer). It cannot be ignored, mainly manifested in extremely toxic and side effects, lack of targeting and very limited therapeutic effect. Therefore, there is an urgent need to find a safe, efficient a...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/48A61P35/00
CPCA61K41/00
Inventor 于淼李正林孙晔范雪蕾李卓
Owner HARBIN INST OF TECH
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