Topical ointment for treating kinesia and producing method thereof

Abstract

The invention discloses a topical ointment for treating kinesia and a producing method thereof, and aims at providing a topical ointment which is fast to achieve the effect, convenient to apply, few in side effect and capable of increasing and decreasing the using amount at any time to adapt to the different individual needs and is used for treating the kinesia and a producing method thereof. The topical ointment for treating the kinesia is prepared from camphor, menthol, eucalyptus oil, scopolamine hydrobromide, a penetration enhancer and an ointment base, wherein at least one of azone and propylene glycol is adopted as the penetration enhancer, and at least one of wool fat and white vaseline is adopted as the ointment base. According to the topical ointment for treating the kinesia, ointment applying is convenient, the effects are achieved quickly, the medicine effect components can be absorbed quickly, and the effective plasma concentration can be reached; the topical ointment can be used 10 minutes before people ride a transportation vehicle, the effects are quickly achieved after about 10 minutes, and the medicine effect can maintain 5-6 hours.

Description

technical field [0001] The invention relates to a medicine for treating motion sickness, in particular to a transdermal preparation for treating motion sickness and a production method thereof. Background technique [0002] Motion sickness is a general term for motion sickness, seasickness, airsickness, and diseases caused by various reasons such as swinging, bumping, rotating, and accelerated motion. Scopolamine is an anti-M-cholinergic receptor drug. Because it easily penetrates the blood-brain barrier, it also has central anticholinergic effects, mainly manifesting inhibition and sedation; because it can selectively inhibit the motility of vestibular neurons or Spontaneous excitatory discharge has good anti-dizziness and antiemetic effects; however, oral anti-dizziness is often accompanied by side effects such as dry mouth, mydriasis, blurred vision, drowsiness and palpitations, which limits its application. Through research, using scopolamine as a raw material to make a...

AI Technical Summary

Problems solved by technology

Scopolamine is an anti-M-cholinergic receptor drug. Because it easily penetrates the blood-brain barrier, it also has central anticholinergic effects, mainly manifesting inhibition and sedation; because it can selectively inhibit the motility of vestibular neurons or Spontaneous excitatory discharge has good anti-dizziness and antiemetic effects; however, oral anti-dizziness is often accompanied by side effects such as dry mouth, dilated pupils, blurred vision, drowsiness and palpitations, which limits the application.

Through research, using scopolamine as a raw material to make a plaster can separate the anti-dizziness and antiemetic effects of scopolamine from side effects such as dry mouth, dilated pupils, drowsiness and heart palpitations; however, due to the limited area of ​​the plaster, it is difficult to quickly absorb and reach an effective blood concentration. , so the effect is slow and weak, it is difficult to guarantee the efficacy