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A kind of preparation method of step-release drug carrier based on two-phase system

A two-phase system, step-by-step release technology, used in pharmaceutical formulations, medical preparations with non-active ingredients, liquid delivery, etc., can solve the problems of normal cytotoxic side effects, drug accumulation, etc. The effect of maintaining blood concentration and improving curative effect

Active Publication Date: 2018-03-16
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The release curve of the existing drug carrier is generally an exponential curve, and the release plateau is reached soon after the burst release, which is easy to cause drug accumulation and has serious side effects on normal cells.

Method used

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  • A kind of preparation method of step-release drug carrier based on two-phase system
  • A kind of preparation method of step-release drug carrier based on two-phase system
  • A kind of preparation method of step-release drug carrier based on two-phase system

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specific Embodiment approach 1

[0024] Specific embodiment 1: This embodiment is a preparation method of a step-by-step release drug carrier based on a two-phase system, which is completed in the following steps:

[0025] 1. ITO surface cleaning: First, use absolute ethanol to ultrasonically clean two pieces of ITO glass electrodes for 15-20 minutes to obtain two pieces of ITO glass electrodes after cleaning with absolute ethanol; then use distilled water to clean the two pieces of ITO glass electrodes with absolute ethanol Electrodes were ultrasonically cleaned for 15-20 minutes, and finally dried with nitrogen to obtain two cleaned ITO glass electrodes;

[0026] 2. Dissolve polyethylene glycol 20000 and Dextran500000 in distilled water to obtain a two-phase aqueous solution;

[0027] The volume ratio of the mass of polyethylene glycol 20000 described in step 2 to distilled water is 0.09g: (2.5mL~3mL);

[0028] The volume ratio of the mass of Dextran500000 described in step 2 to distilled water is 0.1g: (2...

specific Embodiment approach 2

[0039] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the mass of dipalmitoylphosphatidylcholine described in step three and the volume ratio of chloroform are 5mg:1mL. Other steps are the same as in the first embodiment.

specific Embodiment approach 3

[0040] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the volume ratio of the polyethylene glycol 20000 described in step 2 to distilled water is 0.09g:2.8mL. Other steps are the same as those in Embodiment 1 or 2.

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Abstract

The invention relates to a method of preparing a release pharmaceutical carrier, in particular to a method of preparing a stepwise release pharmaceutical carrier based on an aqueous two-phase system and aims to solve the problem that a pharmaceutical carrier of the prior art has a release curve that is an index curve and arrives at a release platform right after burst release. The method comprises: 1, performing ITO (indium tin oxide) surface cleaning; 2, preparing an aqueous two-phase solution; 3, preparing a vesicle solution; 4, assembling a closed preparation apparatus, and allowing reacting to obtain the stepwise release pharmaceutical carrier based on the aqueous two-phase system. The stepwise release pharmaceutical carrier based on the aqueous two-phase system prepared by the invention is stored in two phases and released separately, the release platform is pushed back, and the carrier has the advantages such as convenience of use, maintenance of normal blood concentration, avoidance of pharmaceutical accumulation, low toxic and side effect for normal cell tissues, improved therapeutic effect, safety and high speed. The stepwise release pharmaceutical carrier based on the aqueous two-phase system can be prepared by the method.

Description

technical field [0001] The invention relates to a preparation method for releasing a drug carrier. Background technique [0002] The drug is released quantitatively and uniformly through the controlled release coating to keep the blood drug concentration constant. The function of controlled drug release can be achieved through membrane permeation control system and body diffusion system. The targeted release function of drugs can be implemented through biological understanding mechanism, penetration mechanism, and in vitro control. Features such as safety and speed. [0003] The release curve of the existing drug carrier is generally an exponential curve, and the release plateau is reached soon after the burst release, which is likely to cause drug accumulation and have serious side effects on normal cells. Contents of the invention [0004] The purpose of the present invention is to solve the problem that the release curve of the drug carrier in the prior art is an exp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K47/10A61K47/36A61K9/127A61K47/24
CPCA61K9/10A61K9/127A61K47/24A61K47/34A61K47/36
Inventor 韩晓军张旭男
Owner HARBIN INST OF TECH
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