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Conjugated polyelectrolyte for fluorine ion detection, preparation of conjugated polyelectrolyte and application of conjugated polyelectrolyte

A technology of conjugated polyelectrolyte and fluoride ions, which is applied in chemical instruments and methods, fluorescence/phosphorescence, luminescent materials, etc., can solve the problems that fluoride ions cannot be detected, sodium fluoride cannot be detected, and cytotoxicity is high, etc., and achieve high Sensitivity and accuracy of detection, good selective recognition, and good effect of cell viability

Active Publication Date: 2016-02-03
NANJING UNIV OF POSTS & TELECOMM
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, people have successfully designed a series of chemical sensors for fluorine ions (Zhou, Y.etal.Chem.Rev.2014, 114, 5511-5571). These probe materials can achieve high resolution and high sensitivity in a simple and real-time manner. However, there are various limitations: most fluoride ion sensors can only be carried out in organic solvents, and can only detect organic fluoride ions (existing in the form of tetrabutylammonium fluoride), but cannot detect Inorganic sodium fluoride; some reported fluoride ion sensors cannot be used for the detection of fluoride ions in cells due to limitations such as poor water solubility, inability to detect in cells, and high toxicity to cells

Method used

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  • Conjugated polyelectrolyte for fluorine ion detection, preparation of conjugated polyelectrolyte and application of conjugated polyelectrolyte
  • Conjugated polyelectrolyte for fluorine ion detection, preparation of conjugated polyelectrolyte and application of conjugated polyelectrolyte
  • Conjugated polyelectrolyte for fluorine ion detection, preparation of conjugated polyelectrolyte and application of conjugated polyelectrolyte

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Experimental program
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Effect test

Embodiment 1

[0050] Embodiment 1: Preparation of conjugated polyelectrolyte

[0051] Because in the two preparation methods provided by the present invention, compared with the first preparation method, the second preparation method only does not have the preparation process of polymer precursor B, so the first preparation method provided by the present invention is adopted in this embodiment , and the second preparation method is similar to this embodiment except for the preparation process of the polymer precursor B, and will not be described in detail.

[0052]

[0053] (1) Preparation of polymer precursor A: weigh 5,5'-dibromo-2,2'-bipyridyl (10.0mg, 0.032mmol), fluorene monomer (44.2mg, 0.068mmol) in a reaction test tube , borate monomer (74.4mg, 0.1mmol), phase transfer catalyst tetrabutylammonium bromide trace, tetrakis (triphenylphosphine) palladium catalytic amount. The system is sealed, protected from light, pumped to remove oxygen, and protected by nitrogen. Add solvent tol...

Embodiment 2

[0060] Example 2: Detection of fluoride ions in aqueous solution by the conjugated polyelectrolyte

[0061] The configuration concentration is 4.8×10 -1 mol / L NaF aqueous solution, diluted to the required concentration during the test.

[0062] Prepare the methanol solution of the conjugated polyelectrolyte prepared in Example 1 with a concentration of 1 mg / mL, and dilute it to the required concentration with PBS buffer solution of pH=7.4 during the test.

[0063] Under room temperature conditions, the change of fluorescence emission intensity during the process of adding fluoride ions to the conjugated polyelectrolyte solution was tested with a transient fluorescence photometer, and the fluorescence titration diagram and titration data fitting diagram are shown as figure 2 and image 3 shown. From figure 2 It can be seen from the figure that with the increase of the concentration of fluoride ions in the system, the fluorescence intensity of the conjugated polyelectrolyt...

Embodiment 3

[0065] Example 3: Response of the conjugated polyelectrolyte to other anions

[0066] Configured separately with CO 3 2- , HSO 4 - ,NO 2 - ,NO 3 - ,CH 3 COO - , HSO 3 - , HCO 3 - , Cl - ,Br - aqueous solution, the concentration is 4.8×10 -1 mol / L.

[0067] The methanol solution of the conjugated polyelectrolyte prepared in Example 1 was prepared at a concentration of 1 mg / mL, and diluted to the required concentration with PBS buffer solution of pH=7.4 during the test.

[0068] At room temperature, the fluorescence emission spectrum of the conjugated polyelectrolyte solution before and after adding anions was tested with a transient fluorescence photometer to study its response to different anions. Figure 4 It is the change of fluorescence intensity at 600 nm of the conjugated polyelectrolyte before and after adding various anions. It can be seen from the figure that the conjugated polyelectrolyte has basically no response to the fluorescence of other common ...

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Abstract

The invention belongs to the technical field of fluorine ion detection and conjugated polyelectrolyte, and particularly relates to a conjugated polyelectrolyte capable of being used for fluorine ion detection, a preparation method of the conjugated polyelectrolyte and application of the conjugated polyelectrolyte to the field of fluorine ion chemicobiological sensors. The conjugated polyelectrolyte provided by the invention has a main chain structure of the conjugated polymers and an iridium complex substituting structure; through the main chain structure of the conjugated polymers, blue fluorescence can be emitted under the ultraviolet ray irradiation; through the iridium complex structure, red phosphorescence can be emitted under the visible light irradiation. The fluorine ions can promote the Si-O bound fracture in the iridium complex, so that the red light emission of the iridium complex quenches. The conjugated polyelectrolyte provides the possibility for building the chemicobiological sensors for high-selectivity and high-sensitivity detection of the fluorine ions. Meanwhile, better water solubility and biocompatibility are realized; the detection on the fluorine ions in the water solution and in the cells can be realized. The molecular formula of the conjugated polyelectrolyte is shown as the formula provided by the accompanying drawing, wherein the Ar is selected from the following substances shown as the accompanying drawing.

Description

technical field [0001] The invention belongs to the technical field of fluoride ion detection and conjugated polyelectrolyte, and specifically relates to a conjugated polyelectrolyte that can be used for fluoride ion detection, a preparation method of the conjugated polyelectrolyte and its use in the field of fluoride ion chemical biosensors. Background technique [0002] Ions widely exist in nature and play an important role in the fields of biology, environment and chemical industry. Controlling harmful ionic pollution is a serious issue at present, so designing and synthesizing chemical sensors that can selectively identify various ions is an important challenge in the field of chemical science. Among them, the water-soluble conjugated polymer fluorescence / phosphorescence sensor can amplify the signal of molecular recognition and convert it into a perceivable optical signal, which has the characteristics of high sensitivity, fast response time, and low detection limit. C...

Claims

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Application Information

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IPC IPC(8): C08G61/12C09K11/06G01N21/64
Inventor 赵强黄维蒋嘉洋刘淑娟许文娟张传起
Owner NANJING UNIV OF POSTS & TELECOMM
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