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Method for preparing drug sustained-release coating by vacuum cold spray coating technology and product prepared by method

A technology for preparing medicines and vacuum cooling, which is applied in coating, surgery, medical science, etc., can solve the problems of lack of biological activity and osteoinductive performance, and achieve the effect of low cost, high bonding strength and broad application prospects

Active Publication Date: 2016-01-20
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Medical metals and alloys have an elastic modulus similar to that of human bone, so they have been more and more widely used in the medical field. However, the lack of bioactivity and osteoinductive properties has greatly limited their applications. The surface modification of medical metals and alloys And treatment is the current effective method to improve its biological inertness

Method used

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  • Method for preparing drug sustained-release coating by vacuum cold spray coating technology and product prepared by method
  • Method for preparing drug sustained-release coating by vacuum cold spray coating technology and product prepared by method

Examples

Experimental program
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Embodiment 1

[0027] In this embodiment, the base material is a 2×2mm titanium sheet, and the obtained slow-release coating is well combined with the base material. The specific preparation method of slow-release coating is as follows:

[0028] (1) Clean the substrate with acetone, alcohol, and deionized water in sequence. After drying, use 60-mesh brown corundum sand to roughen the surface of the substrate. The air pressure used for sandblasting is 0.5MPa, and the blasting time is 30s;

[0029] (2) Preparation of HA: under stirring conditions, an equal volume of (NH 4 ) 2 HPO 4 The solution was added dropwise to 2.5mol / L Ca(NO 3 ) 2 solution, and then adjust the pH value of the mixed solution to between 10 and 11 with ammonia water, age the resulting flocculent precipitate for 7 days, wash the precipitate with deionized water until pH = 7, and dry the precipitate to obtain HA , the particle size is about 600nm.

[0030] (3) Drug (gentamycin) and HA are added in PBS (phosphate buffere...

Embodiment 2

[0034] In this embodiment, the base material is a 2×2mm titanium sheet, and the coating is well bonded to the base material. The specific preparation method of slow-release coating is as follows:

[0035] (1) Clean the substrate with acetone, alcohol, deionized water, etc. in sequence, and use 60-mesh brown corundum sand to roughen the surface of the substrate. The air pressure used for sandblasting is 0.5MPa, and the blasting time is 30s;

[0036] (2) Add the drug (gentamycin) and titanium dioxide to PBS, and stir at room temperature for 30 minutes to compound. In the obtained solution, the concentration of gentamicin is 0.001g / mL, and the concentration of titanium dioxide is 0.1g / mL, washed with deionized water, centrifuged and freeze-dried to obtain drug-loaded titanium dioxide with an average particle size of 800nm.

[0037] (4) Spray the drug-loaded titanium dioxide onto the treated substrate surface using vacuum cold spraying technology. The process parameters for cont...

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Abstract

The invention discloses a method for preparing a drug sustained-release coating by vacuum cold spray coating technology. According to the method, the prepared medicine or bioactive factor loaded composite powder is sprayed onto the surface of a roughly treated medical material by vacuum cold spray coating technology. Due to the fact that the material prepared by the method can effectively control releasing of the medicine or a bioactive factor, the phenomenon of burst-releasing is avoided. Due to the fact that the vacuum cold spray coating technology adopted by the method can be operated at the room temperature, temperature sensitive materials, such as the medicine or the bioactive factor, are prevented from being decomposed or deactivated, and the organization structure and the physical and chemical performance of original powder can be effectively maintained. Meanwhile, the biostability of the coating is good, the powder is easy to reclaim, and the operation is simple and convenient to perform.

Description

technical field [0001] The invention relates to the field of surface modification, in particular to a method for preparing drug sustained-release coatings by using vacuum cold spraying technology. Background technique [0002] Medical metals and alloys have an elastic modulus similar to that of human bone, so they have been more and more widely used in the medical field. However, the lack of bioactivity and osteoinductive properties has greatly limited their applications. The surface modification of medical metals and alloys And treatment is an effective way to improve its biological inertia. [0003] Vacuum cold spraying technology uses high-speed airflow to accelerate solid particles, and after acceleration, they hit the preset substrate at high speed, so that the particles are plastically deformed and flattened to form a coating. Compared with the traditional thermal spraying technology, the operating temperature of vacuum cold spraying is room temperature, there is almo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/08A61L31/02A61L31/16A61L27/06A61L27/32A61L27/54C23C24/02
Inventor 陈秀勇李德燕刘奕李华
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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