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Medicinal composition for treating renal diseases and pharmaceutical use of medicinal composition

A kind of technology of kidney disease and composition, applied in the field of composition for treating kidney disease

Inactive Publication Date: 2015-11-04
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Although some of the above ingredients have been reported to treat certain diseases, there are no reports of rhein, emodin methyl ether, danshensu, salvianolic acid B, salvianolic acid A, hydroxysafflower yellow A, verbascoside, A report on the combination of chrysophanol glycoside, emodin glycoside and emodin methyl ether glycoside with fixed dosage for the treatment of kidney and other organ diseases

Method used

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  • Medicinal composition for treating renal diseases and pharmaceutical use of medicinal composition
  • Medicinal composition for treating renal diseases and pharmaceutical use of medicinal composition
  • Medicinal composition for treating renal diseases and pharmaceutical use of medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0138] Take 0.5g of rhein, 0.4g of emodin methyl ether, 0.4g of emodin glucoside, 0.4g of chrysophanol glucoside, 0.5g of danshensu, 0.2g of salvianolic acid B, 0.4g of hydroxyl safflower yellow pigment A, Glycoside 0.2g, astragalus polysaccharide 0.4g, salvianolic acid A0.1g, verbascoside glycosides 0.4g, add PEG-20050ml, add water for injection to dilute to 500ml, filter, add water for injection to 800ml, adjust the pH value to 6.5- 7.0, add water for injection and dilute to 1000ml, filter through a 0.22μm microporous membrane, subpackage, and sterilize to obtain an injection.

Embodiment 2

[0140] Take 50g rhein, 40g emodin methyl ether, 40g chrysophanol glucose sugar, 40g emodin glucoside, 50g salvianol, 20g salvianolic acid B, 40g hydroxyl safflower yellow A, 20g astragaloside IV, 40g astragalus polysaccharide, salvianol Acid A10g, acteocoside 40g, appropriate amount of meglumine and arginine, add water for injection to dilute to 5L, stir until dissolved, filter, adjust the pH value of the filtrate to 5.0-7.0, and use a 0.22μm microporous membrane for fine filtration ; Take an appropriate amount of mannitol and add water for injection to prepare a solution, mix with the above filtrate, filter with a 0.22 μm microporous membrane, add water for injection to dilute to 10L, pack according to the dosage of 10ml of the unit preparation, freeze-dry, and obtain freeze-dried pink.

Embodiment 3

[0142]Take 15.6g of rhein, 12.5g of emodin methyl ether, 12.5g of chrysophanol glucose sugar, 12.5g of emodin glucoside, 15.6g of salvia miltiorrhiza, 6.5g of salvianolic acid B, 12.5g of hydroxyl safflower yellow pigment A, astragalus Glycoside 5.2g, astragalus polysaccharide 10.4g, salvianolic acid A3.5g, verbascoside 12.5g, pre-crossed starch, micropowder silica gel, magnesium stearate, talcum powder, pass through 80 mesh sieve respectively, and mix with the powder evenly , add an appropriate amount of binder to make a soft material, granulate, and dry the granules at 60°C. Add micropowder silica gel, magnesium stearate and talcum powder, mix evenly, and press into 1000 tablets.

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Abstract

The invention relates to a medicinal composition for treating renal diseases and the pharmaceutical use of the medicinal composition. The composition contains rhein, physcion, emodin glucoside, chrysophanol glucoside, salvianic acid, salvianolic acid B, hydroxysafflor yellow A, astragaloside, astragalus polysaccharide, salvianolic acid A, calycosin-7-glucoside, physcion glucoside, rosmarinic acid, carthamin yellow A, salvianolic acid D, salvianolic acid H, protocatechuic aldehyde, caffeic acid and gallic acid, wherein the chrysophanol glucoside is chrysophanol monoglucoside, the emodin glucoside is emodin monoglucoside, and the physcion glucoside is physcion monoglucoside. The composition can also contain C11H9N6O4, C17H14O4, C21H20O9, C19H32O12, C30H36O15 and C30H44O15. The composition is a preparation in a solid form, a liquid form, a gas form or a semisolid form, and a great number of experiments show that the composition can be used for treating renal diseases, renal failure, nephrotic syndromes, cardiovascular and cerebrovascular diseases, neoplastic diseases and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a composition for treating kidney diseases and an application thereof. Background technique [0002] The patent of this invention is based on the patents ZL96117626.1 "Shenkang Injection and Its Preparation Process" and ZL201110325891.4 "A Shenkang Injection Compound Preparation for the Treatment of Chronic Renal Failure and Its Preparation Method" and other inventions already owned by the applicant Further research done on the basis of patents. Shenkang injection is made from rhubarb, salvia miltiorrhiza, safflower, and astragalus as raw materials, extracted and refined at a fixed dosage ratio. Take rhubarb and Salvia miltiorrhiza, add water to decoct, concentrate the decoction, add ethanol to precipitate, absorb the supernatant, recover the ethanol, add gelatin solution and let stand to remove tannin, and use the supernatant after removing tannin for later use. Take safflo...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P13/12A61P35/00A61P9/00
Inventor 吴芳吕延英王光建赵兴詹芳王俊平贾诚曾艳龙
Owner XIAN SHIJISHENGKANG PHARMA IND
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