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Oleanolic acid based drug slow-release agent and preparation method thereof

The technology of oleanolic acid and sustained-release agent is applied in the field of drug sustained-release agent based on oleanolic acid and its preparation, and can solve the problems of large fluctuation of blood drug concentration, low bioavailability, poor dissolution and the like, Achieve stable drug concentration, avoid drug concentration fluctuations, and improve solubility

Inactive Publication Date: 2015-05-20
SCHOOL OF MEDICINE JIAYING UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] The present invention aims at the problems existing in the prior art, and aims at the problems of poor dissolution rate, large blood drug concentration fluctuation and low bioavailability of current oleanolic acid drugs, and prepares a drug slow-release agent of oleanolic acid. The prepared drug sustained release agent has the characteristics of stable drug concentration, high biological activity, good drug solubility and long drug effect time

Method used

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  • Oleanolic acid based drug slow-release agent and preparation method thereof
  • Oleanolic acid based drug slow-release agent and preparation method thereof

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Embodiment Construction

[0031] In order to further understand the content of the present invention, the content of the invention will be specifically described below in conjunction with the accompanying drawings and specific embodiments:

[0032]A drug sustained-release agent based on oleanolic acid and a preparation method thereof, comprising the following steps:

[0033] The first step, the preparation of the clathrate, according to the mass ratio of oleanolic acid to the drug carrier is 0.1:0.1 ~ 0.1:5, over-precipitation method, solution method, kneading method, grinding method, ultrasonic method, freeze-drying method or The clathrate is prepared by spray drying method, and the drug carrier is β-cyclodextrin-chitosan composite material.

[0034] The β-cyclodextrin-chitosan composite material includes unmodified β-cyclodextrin-chitosan composite material and modified functionalized β-cyclodextrin-chitosan composite material.

[0035] The modified functionalized β-cyclodextrin-chitosan composite m...

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Abstract

The invention relates to the technical field of oleanolic acid drugs, and provides an oleanolic acid based drug slow-release agent and a preparation method thereof. The oleanolic acid based drug slow-release agent is applied to drugs taking an oleanolic acid as a main drug ingredient, and comprises a drug carrier, a hydrophilic gel material, an erodible matrix material and an insoluble matrix material, and the drug slow-release agent is characterized in that the drug carrier is a beta-cyclodextrin-chitosan composite material, the oleanolic acid is derived from plant materials, and the main drug ingredient and the drug carrier form a host-guest complex in a mass ratio of 0.1:0.1-0.1:5. The preparation method comprises the steps of complex preparation, auxiliary material mixing, compression molding, and the like. The oleanolic acid based drug slow-release agent disclosed by the invention has the characteristics of stable drug concentration, high biological activity, good drug solubility and long drug effect duration time.

Description

technical field [0001] The invention relates to the technical field of oleanolic acid medicines, in particular to a drug slow-release agent based on oleanolic acid and a preparation method thereof. Background technique [0002] Oleanolic acid is an adjuvant drug for liver diseases. It is clinically used to treat infectious acute jaundice hepatitis. It has obvious effects of reducing alanine aminotransferase and jaundice, effectively reducing enzymes and turbidity, correcting abnormal protein metabolism, improving virality and chronic persistence Symptoms of patients with chronic hepatitis, promote liver cell regeneration, prevent liver cirrhosis and liver ascites; it can also be used for psoriasis, rheumatoid arthritis, nephritis, edema, stomach pain and stranguria, blood metrorrhagia, bruises, carbuncle, soreness of the waist and knees, Fetal restlessness and other diseases have broad application prospects. [0003] Currently on the market, oleanolic acid sustained-release...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/56A61P1/16A61P17/06A61P29/00A61P19/02A61P13/12A61P7/10A61P1/00A61P7/04A61P15/06
CPCC08B37/0015C08L5/08A61K47/6951A61K31/19A61P1/00A61P1/16A61P13/12A61P15/06A61P17/06A61P19/02A61P29/00A61P7/04A61P7/10
Inventor 程金生
Owner SCHOOL OF MEDICINE JIAYING UNIV
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