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Polygonatum kingianum polysaccharide extract with sugar and lipid metabolism regulating activity and preparation method thereof

An extraction method and technology of Polygonatum chinensis, applied in the directions of organic active ingredients, medical preparations containing active ingredients, metabolic diseases, etc., can solve the problems of affecting the extraction rate of polysaccharides, long time, complex decolorization process, etc.

Inactive Publication Date: 2015-04-01
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above polysaccharide preparation method has the following deficiencies: First, frequent heating during the degreasing process of medicinal materials results in a large loss of polysaccharides, which affects the extraction rate of polysaccharides; secondly, the degreasing and decolorization processes are complex, time-consuming, and costly, making it difficult to scale production; in addition, conventional The polysaccharide prepared by the method contains more impurities, including macromolecular substances such as protein, starch and phenolic substances, and small molecular substances such as glucose and fructose.

Method used

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  • Polygonatum kingianum polysaccharide extract with sugar and lipid metabolism regulating activity and preparation method thereof
  • Polygonatum kingianum polysaccharide extract with sugar and lipid metabolism regulating activity and preparation method thereof
  • Polygonatum kingianum polysaccharide extract with sugar and lipid metabolism regulating activity and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Wash the Sheng Dianhuang essence and dry it naturally. After drying, the dry product gain is 20%. The Dianhuang essence is made into thick powder, and 100g of powder is taken.The time is 1.5h, 1H, and 0.5H, respectively, and the extraction temperature is set to 80 ° C.Merge three extraction solution, the concentration concentration is 1g / ml (native medicine).Filter with a 4x amount of water-free ethanol after 24 hours, dissolved with distilled water with distilled water, add α-amylase to starch, and then use 4 times the amount of water-free ethanol to precipitate. Under the same conditions, Wash the fat -soluble ingredients of the ether, ventilate and dry at room temperature, wave organic solvents, and get yellow powder with a wet weight of 67.2g.The powder is dissolved with distilled water, then the egg is used to remove the egg with the Sevage method. After swinging the organic solvent, the flowing dialysis is for 2 days.

Embodiment 2

[0024] After the laboratory is extracted with 80%ethanol to extract the saponin, the Dianhuang essence powder is recovered. After drying it naturally, it is called 100g, and the refinement is extracted with the same method above.After refining, freeze and dry 9 g.

Embodiment 3

[0026] Preparation of Dianhuang essence polysaccharides: Based on weight, in the unit of kilograms, it is called: 100 Dianhuang essence polysaccharides, 300 codenol alcohols, 250 vulva, 250 microcrystalline cellulose, 50 copies of methamphetamine, and 50 copies of methamphetamine., 25 citric acid and 25 parts of magnesium hyperlipate.

[0027] The above -mentioned Dianhuang essence polysaccharides, xylitol, paste, microcrystalline cellulose, and chitin are fully mixed, wetting with water, making soft materials, sieved and drying, add citric acid, magnesium, magnesiumPress the film, weighs 250mg per piece, and the active ingredients Dianhuang essence polysaccharide contain 25mg.

[0028] The invention of the Dianhuang essence of the Dianhuang essence has the effects of reducing the triglyceride and cholesterol of glycerin and cholesterol, and has a certain α glucosidase inhibitory rate. The result shows that yellow essence polysaccharides can be used to prevent and regulate sugar -...

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Abstract

The invention discloses an extraction method and application of polygonatum kingianum polysaccharide. The extraction method comprises the following steps: cleaning and slicing polygonatum kingianum taken as a raw material, naturally drying in the sun, and then grinding into coarse powder; extracting with distilled water for three times, then concentrating to a certain concentration, and depositing by using anhydrous ethanol to obtain a polygonatum kingianum polysaccharide crude product; dissolving by using distilled water, adding alpha-amylase to remove starch, depositing by using anhydrous ethanol, and then washing by using anhydrous ethanol, acetone and ethyl ether to remove fat-soluble components to obtain yellow powder; removing protein by using a Sevage method after deionized water dissolution, volatilizing an organic solvent, then performing dialysis, and finally freeze-drying to obtain white powder namely polygonatum kingianum polysaccharide. The obtained polygonatum kingianum polysaccharide is used for preparing tablets and has effects of reducing blood pressure, blood fat and blood sugar.

Description

Technical field [0001] The invention involves the field of Chinese medicine extraction, which specifically involves an extract and preparation method for Dianhuang essence polysaccharides. Background technique [0002] Huang Jing is an important dual -use resource in my country. "China Pharmacopoeia" 2010 edition is a yellow essence as a lily of the yellow essence. Dry rhizomes are called "rhubarb", "chicken head yellow essence" or "ginger yellow essence". [0003] Dianhuang essence is large in Yunnan. It has its medicinal records in "Southern Yunnan Materia Medica" and "Yunnan Plant House". It is an important "cloud medicine" variety.Wide clinical application foundation and good in -depth development prospects. [0004] Dianhuang essence polysaccharide has always been considered the main type of chemical component in Dianhuang essence, and it is also the chemical composition of the quality control of Dianhuang essence in the 2010 version of "Chinese Pharmacopoeia".Research sho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61K9/20A61P3/06A61P3/10
Inventor 俞捷赵荣华闫鸿丽
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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