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Microtubule containing radionuclide as well as manufacturing method and application of microtubule

A technology of a radionuclide and a manufacturing method, which is applied in the field of microtubes containing radionuclides and its manufacturing, can solve the problem of uneven distribution of dosimetry, difficult operation of slow-release agents and slow-release drugs, and difficult to remove radioactive surface contamination. and other problems to achieve the effect of ensuring easy operability and uniform radiation dose

Active Publication Date: 2015-03-25
CHENGDU WEINING BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The above-mentioned methods have been widely used in the treatment of tumors. While they solve the problems of reducing damage to normal tissues, reducing the pain of patients, and providing different treatment options for inoperable patients, there are still many problems. Problems, such as uneven distribution of dosimetry, difficult removal of radioactive surface contamination, control of sustained release rate of sustained-release agents, and difficult handling during drug implantation, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] A: Microtubule Fabrication

[0060] Slowly add 2.0ml of gelatin solution (150g / L) dropwise into 12ml of liquid paraffin containing 0.1ml of Span-80, and stir at 60°C for 30min to obtain an emulsion. The emulsion was transferred to an ice bath, rapidly cooled to below 5°C, and after 8 minutes of ice bath, 0.5 ml of glutaraldehyde was added and stirring continued for 30 minutes. The microspheres were dehydrated and deoiled with acetone, filtered and dried to obtain the microspheres.

[0061] Swell 50 mg of gelatin microspheres in PBS and KI solution for 10 min, then add 50 mCi of Na125I, add chloramine-T solution at room temperature and stir for 30 min, then centrifuge the microspheres to obtain labeled 125I- Gelatin microspheres.

[0062] The microspheres were packed into magnesium alloy microtubes with a length of 5 cm and an outer diameter of 0.5 cm, and two sections were welded and sealed to obtain target microtubes, and the activity of a single micr...

Embodiment 2

[0068] A: Microtubule Fabrication

[0069] Dissolve 0.3g of paclitaxel in 5ml of chloroform, add 2ml of Tween 80 and stir evenly, then add 2g of cyclodextrin, mix evenly and stir while making the chloroform volatilize, and stop stirring after the mixture becomes a thick paste. Transfer the mixture to an extruder, extrude it into a columnar shape with a length of 3 cm and a diameter of 0.2 cm, and after drying, put it into a section with a length of 1 cm, an outer diameter of 0.2 cm, and an inner diameter of 0.1 cm, with a uniform diameter of 0.1 mm etched on the surface. The polyethylene microtubules obtained are the target microtubules.

[0070] B: microtubule implantation

[0071] For a case of female non-small cell lung cancer, the patient was 55 years old, the lesion was located in the right lower lung with mediastinal lymph node enlargement, and the tumor diameter was 3.5cm. The usage is subcutaneous administration: after routine disinfection, use 0.5% l...

Embodiment 3

[0075] A: Microtubule Fabrication

[0076] Weigh 2g of hyaluronic acid and dissolve it in 100ml of normal saline to prepare a 2% hyaluronic acid aqueous solution for later use. At 0°C, add sodium phospho[32P] / sodium phosphate solution into 1 ml of 2% hyaluronic acid aqueous solution while stirring, and continue stirring for 30 minutes until the mixture is evenly stirred to obtain a filling solution. Take a 5ml syringe and inject the filler solution into a polyethylene lactide copolymer microtube with a length of 1 cm, an outer diameter of 0.2 cm, and an inner diameter of 0.15 cm. Both ends of the microtube are sealed with medical glue.

[0077] B: microtubule implantation

[0078] The patient is a male, 65 years old, with stage T2a prostate cancer, PSA10ng / ml, taking flutamide for 4 weeks without signs of improvement. After the establishment of TPS, the prostate puncture fixator was connected to the operating table, and the stepper, template and rectal ultras...

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PUM

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Abstract

The invention relates to the field of medical medicine implant, discloses an implantable microtubule used for local treatment and in particular relates to a microtubule containing radionuclide for treating cancers as well as a manufacturing method and an application of the microtubule. The microtubule containing the radionuclide is characterized in that the microtubule is filled with a filler mixed by the radionuclide and a carrier. The invention also relates to a microtubule containing the radionuclide and / or a medicament. The microtubule containing the radionuclide and / or the medicament is characterized in that after uniformly mixing the radionuclide and / or the medicament and the carrier, the mixture is filled in the microtubule to obtain a final microtubule. The microtubule is capable of controlling the radioactivity and the absorbed dose by controlling the composition of the filler and the specification of the microtubule and enabling the radiation dose to be uniform according the traditional implanting and imaging technology, and in addition, also controlling sustained release speed of the radionuclide and / or the medicament according to the length, the diameter, the filler, sealing or not, opening or not and degradation of the microtubule.

Description

technical field [0001] The invention belongs to the field of medical implantation drugs, and relates to an implantable microtube for local treatment, in particular to a microtube equipped with radionuclide for treating cancer and its manufacturing method and application. Background technique [0002] In recent years, cancer has become one of the biggest health killers for human beings. In my country, about 1.6 million people suffer from cancer every year, and the death toll is close to 1.3 million, accounting for about 20% of the total death toll. In less than 20 years, the incidence of cancer in my country has increased by nearly 70%. According to the statistics of the World Health Organization, the incidence of cancer in the world will increase by 50% by 2020. [0003] Today, there are two main types of implantable cancer drugs: brachytherapy and local slow-release agents for chemotherapy. Brachytherapy refers to radiation therapy in which radiation sources are implanted...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/12A61K51/06A61K45/00A61P35/00
CPCA61K45/00A61K51/06A61K51/12
Inventor 韩东乔王铖锴
Owner CHENGDU WEINING BIOLOGICAL TECH
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