Granules for treating senile hyperthyroidism and preparation method thereof

A granule and senile technology, which is applied in the field of granules for the treatment of senile hyperthyroidism and its preparation, which can solve the problems of narrow drug safety range, unsatisfactory effect, easy induction and masking of hypoglycemia symptoms, etc.

Inactive Publication Date: 2014-12-03
李晨芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to this special pathological manifestation, the existing drugs for the treatment of hyperthyroidism are used in the elderly, the effect is not ideal, and the drug safety range is narrow
The average level of catecholamines is higher than normal, but at the same time, the consumption of catecholamines is also higher than normal. If the dosage of catecholamine antagonists is slightly too large, it is easy to cause autonomic imbalance, leading to hypotension, and even life-threatening
As a result, most of the current treatment methods only regulate thyroxine and control the symptoms of hyperthyroidism. For tachycardia, atrial fibrillation and other cardiovascular manifestations that are clearly related to the level of catecholamines, they can only be adjusted by the body after controlling hyperthyroidism.
It has also been reported clinically that the use of β-blockers (such as metoprolol) to control the heart rate of elderly patients with hyperthyroidism, but hyperthyroidism is not a simple disease, often accompanied by glucose metabolism disorders, diabetes, and β-blockers interfere with glucose metabolism , easy to induce and cover up hypoglycemia symptoms, limiting its application
[0004] Therefore, there is still a lack of a drug that can effectively control the high level of catecholamines in clinical practice, and can be adjusted in both directions without increasing the depletion of catecholamines, that is, can reduce the impact dose of anti-hyperthyroid drugs, and effectively control heart rate and myocardial metabolism.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1, the weight ratio of raw materials: 20g of alpinia, 10g of safflower parasite, 16g of water safflower, 10g of bergamot, 16g of golden buckwheat stems and leaves, 10g of keel, 10g of August Zha, 15g of nepeta, 10g of kaempferia , Jiulixiang 2g, Elaeagnus 16g, Scallion 20g.

[0036] The preparation method of Example 1 is: mix alpine ginger, safflower parasitic, water safflower seeds, bergamot flowers, golden buckwheat stems and leaves, keel, August Zha, Nepeta, kaempferensis, Jiulixiang, Elaeagnus japonicus, and scallion white Add water to decoct, take the filtrate after 30 minutes, add water to the medicinal dregs and continue decocting for 20 minutes, then take the filtrate, combine the two filtrates, divide into two parts and take it in the morning and evening.

Embodiment 2

[0037] Example 2, the weight ratio of raw materials: 10 parts of alpinia, 6 parts of safflower, 15 parts of water safflower, 6 parts of bergamot, 15 parts of golden buckwheat stems and leaves, 6 parts of keel, 6 parts of August leaves, 12 parts of nepeta, 6 parts of kaempferia, 1 part of Jiulixiang, 15 parts of Elaeagnus japonicus, 10 parts of scallion.

[0038] Prepared as follows:

[0039](1) Boil the scallion white for 0.5 hours, filter the boiling liquid, add crushed sandy date gum powder to the cooking liquid, heat at 80°C until the sandal date gum is completely melted, concentrate to a relative density of 1.2, add cold water drop by drop while heating Cool in medium, take out and dry in the shade to become rubber beads for later use;

[0040] (2) Grind the stems and leaves of bergamot, Nepeta, Gurixiang, and golden buckwheat into powder, pass through a 20-mesh sieve, mix, and extract with supercritical carbon dioxide circulation countercurrent for 6 hours at an extracti...

Embodiment 3

[0043] Example 3, the weight ratio of raw materials: 20 parts of alpinia, 10 parts of safflower, 16 parts of water safflower, 10 parts of bergamot, 16 parts of golden buckwheat stems and leaves, 10 parts of keel, 10 parts of August leaf, 15 parts of nepeta, 10 parts of kaempferia, 2 parts of Jiulixiang, 16 parts of Elaeagnus japonicus, 20 parts of scallion.

[0044] Prepared as follows:

[0045] (1) Boil the scallions for 1 hour, filter the cooking liquid, add the crushed coarse powder of the date gum to the cooking liquid, heat at 90°C until the date gum is completely melted, concentrate to a relative density of 1.3, add cold water drop by drop while heating Cool in medium, take out and dry in the shade to become rubber beads for later use;

[0046] (2) Grind the stems and leaves of bergamot, Nepeta, Gurixiang, and golden buckwheat into powder, pass through a 20-mesh sieve, mix, and extract with supercritical carbon dioxide circulation countercurrent for 6 hours at an extrac...

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PUM

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Abstract

The invention discloses granules for treating senile hyperthyroidism and a preparation method thereof to solve the problem of treatment of senile hyperthyroidism. The preparation method is characterized by comprising the following steps: (1) decocting welsh onion stalks, adding coarse powder of elaeagnus angustifolia L gum to the decoction, heating the materials until the materials are molten, concentrating the solution, dropping the concentrate into cold water one by one while the concentrate is hot to cool the concentrate, and drying the products in the shade to prepare gum beads for later use; (2) grinding flos citri sarcodactylis, fineleaf schizonepeta herb, common jasminorange leaf and twig and fagopyrum dibotrys stem leaves into powder, and extracting the powder to obtain mixed essential oil; (3) poaching alpinia japonica, fiveleaf akebia fruit, fructus polygoni orientalis, scurrula parasitica, fossil fragments and rhizoma kaempferiae, filtering the solution, concentrating the filtrate, heating the concentrate, and adding and grinding the gum beads obtained in the step 1 to dissolve the gum beads; cooling the solution, adding the mixed essential oil obtained in the step 2, and mixing the materials uniformly to prepare an initial material; (4) drying and grinding the initial material obtained in the step 3 to obtain active granules. Clinical experiments prove that the granules have the characteristics of good curative effects and higher safety in conservatively treating senile hyperthyroidism and are worthy of being clinically applied and popularized.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a granule for treating senile hyperthyroidism and a preparation method thereof. Background technique [0002] Hyperthyroidism, referred to as hyperthyroidism, is a group of common endocrine diseases caused by increased synthesis and secretion of thyroid hormone by the thyroid gland, which can occur at any age. The prevalence of hyperthyroidism in the elderly population is about 0.4% to 2.3%, accounting for about 10% to 15% of all hyperthyroid patients, and women are higher than men. Clinical manifestations can be summarized into two groups of symptoms, namely high metabolic rate and high excitability manifestations. Its pathological mechanism lies in the synergistic effect of thyroid hormone and catecholamine, and the former strengthens the excitement and stimulation of the latter in organs such as nerves, cardiovascular and gastrointestinal tract. [0003] Elderly h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9062A61K9/16A61P5/16A61K35/02
CPCA61K35/02A61K36/185A61K36/538A61K36/70A61K36/75A61K36/752A61K36/8962A61K36/906A61K36/9062A61K2300/00
Inventor 李晨芳李世胜赵纪波
Owner 李晨芳
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