Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for improving biological activity of pure titanium surface by using dopamine to be bonded with graphene oxide

A bioactive, dopamine technology, applied in medical science, metal material coating process, prosthesis, etc., to achieve the effect of simple operation and growth promotion

Inactive Publication Date: 2014-11-12
TIANJIN UNIV
View PDF6 Cites 15 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, domestic research on graphene oxide has just started, mainly focusing on the functionalization of graphene oxide (GO) itself, and the application of it to metal substrates has not been reported yet.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for improving biological activity of pure titanium surface by using dopamine to be bonded with graphene oxide
  • Method for improving biological activity of pure titanium surface by using dopamine to be bonded with graphene oxide
  • Method for improving biological activity of pure titanium surface by using dopamine to be bonded with graphene oxide

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] The preparation method step of the present invention design is as follows:

[0025] 1. Polish the pure titanium sheet with water sandpaper so that the surface roughness Ra is not greater than 1 μm, and then use acetone and deionized water to clean it ultrasonically. Nitric acid (HNO 3 ) Soak the sample for 10min-20min to remove surface oxides. After washing with water, immerse the sample in 40-80°C, 5-10mol / L sodium hydroxide (NaOH) solution for 30min-45min. After taking it out, wash the residual sodium hydroxide on the surface with deionized water and dry at room temperature. Acid-base treated pure titanium samples were obtained.

[0026] 2. Prepare 2.0-3.0g / L dopamine-trishydroxymethylaminomethane (DA-Tris) solution.

[0027] 3. Immerse the treated pure titanium sample in the dopamine solution first, and let it stand at room temperature for 12h-24h to prepare the titanium / dopamine sample. After taking it out, wash it with deionized water, immerse it in 2.0-3.0g / L ...

Embodiment 1

[0030] 1) Polish the pure titanium sample with water sandpaper so that the surface roughness Ra is not greater than 1 μm, and then use acetone and deionized water to ultrasonically clean it. Nitric acid (HNO 3 ) (volume fraction 20%) soak the sample for 10 minutes to remove surface oxides. After washing with water, immerse the sample in a 40°C, 5mol / L sodium hydroxide (NaOH) solution for 45 minutes. After taking it out, wash the residual sodium hydroxide on the surface with deionized water and dry it at room temperature. Acid-base treated pure titanium samples were obtained.

[0031] 2) Preparation of 2.0 g / L dopamine-tris(DA-Tris) solution: first prepare a 10 mmol / L tris (Tris) buffer solution with pH=8.5. Take 1.21g tris powder and dissolve it in 800ml deionized water, adjust the pH of the solution to 8.5 with 1mol / L hydrochloric acid (HCl), then pour the solution into a 1000ml volumetric flask for constant volume. Then, take an appropriate amount of dopamine hydrochlorid...

Embodiment 2

[0038] 1) The pure titanium sample was polished smooth with 600, 1000, 2000, and 2500 mesh water sandpaper, and then ultrasonically cleaned with acetone and deionized water. Nitric acid (HNO 3 ) (volume fraction 20%) soak the sample for 15 minutes to remove surface oxides. After washing with water, immerse the sample in a 60°C, 7mol / L sodium hydroxide (NaOH) solution for 40 minutes. After taking it out, wash the residual sodium hydroxide on the surface with deionized water and dry it at room temperature. Acid-base treated pure titanium samples were obtained.

[0039] 2) Preparation of 2.5 g / L dopamine-tris-tris solution (DA-Tris): first prepare a tris buffer solution with pH=8.5. Dissolve 1.21g of Tris powder in 800ml of deionized water, adjust the pH of the solution to 8.5 with 1mol / L hydrochloric acid (HCl), and then pour the solution into a 1000ml volumetric flask for constant volume. Then, take an appropriate amount of dopamine hydrochloride to prepare a 2.0 g / L solutio...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for improving biological activity of a pure titanium surface by using dopamine to be bonded with graphene oxide. The method comprises the following steps: successively carrying out ultrasonic cleaning on a pure titanium sheet of which the surface roughness Ra is not greater than 1micron by adopting acetone and deionized water; carrying out acid treatment by using a nitric acid, cleaning the pure titanium sheet by the deionized water, and then carrying out alkali treatment on a sample by using sodium hydroxide at 40-80 DEG C; preparing a dopamine-trihydroxymethyl aminomethane solution of which the pH is 8.5; soaking the processed pure titanium sample into the prepared dopamine solution, and standing the sample at room temperature for 12-24 hours; taking out the sample, cleaning the sample by using the deionized water, and drying the sample at room temperature, so as to prepare a titanium / dopamine sample; soaking the titanium / dopamine sample into a graphene oxide water solution and standing the sample at room temperature for 12-24 hours; and cleaning the sample by using the deionized water after taking out the sample, drying the sample at room temperature, so as to prepare a titanium / dopamine / graphene oxide sample. The method is simple to operate, green and pollution-free, mass production can be achieved, and a channel is expanded for surface modification of the titanium material.

Description

technical field [0001] The invention relates to a method for preparing a graphene oxide layer on the surface of pure titanium, in particular to a method for improving the biological activity of the surface of pure titanium by using dopamine to connect graphene oxide. Background technique [0002] Titanium and its alloys have been widely used in the field of biomaterials due to their low density and similar elastic modulus to bone. [1] (See: Liang Fanghui et al. Using pre-calcification treatment to improve the surface biological activity of alkaline heat-treated porous titanium [J]. Rare Metal Materials and Engineering, 2004, 33(10): 1359-1364), becoming a good choice for implant materials. However, titanium and its alloys are biologically inert materials, and after being implanted in the human body, they are mostly physically bonded to the bone [2] (See: Wang Xiaohong et al. Effect of TiO2 nanotube crystal form on titanium bioactivity [J]. Functional Materials, 2013, 9(44):...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C23C22/64C23C22/82A61L27/42A61L27/54
Inventor 高颖锟李朝阳朱胜利梁砚琴崔振铎杨贤金
Owner TIANJIN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com