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Preparation method of tebramycin oily injection

A telamycin injection technology, applied in the field of telamycin oily injections, can solve the problems of unfavorable acute severe infection animal treatment, slow onset, etc., achieve convenient administration, weaken pain response, and simple preparation process Effect

Active Publication Date: 2017-07-25
荷本(北京)大药厂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oily injections containing hydrophobic drugs generally have a slow onset of action, which is not conducive to the treatment of animals with acute severe infections

Method used

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  • Preparation method of tebramycin oily injection
  • Preparation method of tebramycin oily injection
  • Preparation method of tebramycin oily injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1, prepare different concentration telamycin injections with ethyl oleate

[0034] Preparation composition: see the table below.

[0035] Numbering Preparation 1 Preparation 2 Preparation 3 Preparation 4 Preparation 5 Preparation 6 Tyramycin (g) 12.5 15 17.5 20 22.5 25 HCO (g) 0.9 0.8 0.7 0.8 0.5 0.3 Soy Lecithin (g) - - 0.7 0.2 0.6 0.4 Antioxidant (g) 0.035 0.035 0.035 0.035 0.035 0.035 Benzyl alcohol (ml) 1 1 1 1 1 1 Glyceryl Formaldehyde (ml) 4 6 6 8 8 10 Tween-80 (ml) 0.5 0.5 0.5 0.5 0.5 0.5 Benzyl Benzoate (ml) 15 20 30 35 40 45 Ethyl oleate (ml) to 100 to 100 to 100 to 100 to 100 to 100

[0036] Preparation method: mix formalin glycerol, benzyl benzoate, Tween-80, benzyl alcohol and 30ml ethyl oleate, add Tyramycin, stir to dissolve it, then add HCO micropowder, soybean lecithin, anti Oxygen agent (BHT0.02g, BHA0.01g, PG0.005...

Embodiment 2

[0037] Embodiment 2, prepare different concentration telamycin injections with IPM

[0038] Preparation composition: see the table below.

[0039] Numbering Preparation 1 Preparation 2 Preparation 3 Preparation 4 Preparation 5 Preparation 6 Tyramycin (g) 12.5 15 17.5 20 22.5 25 HCO (g) 0.6 0.5 0.45 0.4 0.3 0.2 Soy Lecithin (g) - - 0.6 0.3 0.45 0.3 Antioxidant (g) 0.035 0.035 0.035 0.035 0.035 0.035 Benzyl alcohol (ml) 1 1 1 1 1 1 Glyceryl Formaldehyde (ml) 4 6 6 8 8 10 Tween-80 (ml) 0.8 0.8 0.8 0.8 0.8 0.8 Benzyl Benzoate (ml) 15 20 30 35 40 45 IPM (ml) to 100 to 100 to 100 to 100 to 100 to 100

[0040] Preparation method: mix formalin glycerol, benzyl benzoate, Tween-80, benzyl alcohol and 30ml IPM, add Tyramycin, stir to dissolve it, then add HCO micropowder, soybean lecithin, antioxidant ( BHT0.02g, BHA0.01g, PG0.005g) and the remaining amount of...

Embodiment 3

[0041] Embodiment 3, the preparation of telamycin, trimethoprim lactate compound preparation

[0042] Preparation composition: see the table below.

[0043] Numbering Preparation 1 Preparation 2 Preparation 3 Preparation 4 Tyramycin (g) 12.5 15 17.5 20 Lactate TMP (g) 2.5 3 4.4 5 HCO (g) 0.4 0.5 0.45 0.35 Soy Lecithin (g) 0.3 0.3 0.45 0.3 Antioxidant (g) 0.035 0.035 0.035 0.035 Benzyl alcohol (ml) 1 1 1 1 Glyceryl Formaldehyde (ml) 4 6 6 8 Tween-80 (ml) 0.5 0.5 0.5 0.5 Benzyl Benzoate (ml) 15 20 30 35 IPM (ml) to 100 to 100 to 100 to 100

[0044] Preparation method: mix glycerol formaldehyde, benzyl benzoate, Tween-80, benzyl alcohol and 30ml IPM, add Tyramycin, stir to dissolve it, then add trimethoprim lactate, HCO powder, soybean egg Phospholipids, antioxidants (BHT0.02g, BHA0.01g, PG0.005g) and the remaining amount of IPM are ground with a colloid mill and a s...

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Abstract

The invention relates to a preparation method of a tulathromycin oleaginous injection. A cosolvent is glycerolformal / benzyl benzoate / oleaginous medium, the oleaginous medium includes ethyl oleate and isopropyl myristate, and the preparation also contains hydrogenated castor oil and soybean lecithin. The cosolvent can be utilized to prepare a compound preparation of tulathromycin and trimethoprim. The preparation has good stability, good physiological tolerance, and high load capacity, and is a sustained / rapid release oleaginous injection for animals.

Description

technical field [0001] The invention belongs to the technology for preparing veterinary drug preparations, and relates to combining telamycin with an appropriate amount of cosolvent and dissolving them in an oily medium to prepare telamycin oily injections. Background technique [0002] Tulathromycin (Tulathromycin) is a semi-synthetic antibiotic specially used for animals. It has broad antibacterial spectrum, high activity, less clinical dosage, low toxicity, low residue, no teratogenicity, and the entire treatment process can be completed with one administration, etc. Many advantages. Therefore, since Tyramycin was launched on the market, it has attracted widespread attention from all over the world. The commercially available telamycin product is an injection, which is a water-miscible solution type injection. Most of the technologies disclosed in the patents use organic solvent / water co-solvent and acidic conditions to prepare telamycin injection (CN1429232A, CN1014224...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K31/7052A61K47/44A61K47/34A61K47/22A61K47/14A61P31/04A61K47/26
Inventor 王玉万潘贞德戴晓曦任雅楠沈力
Owner 荷本(北京)大药厂有限公司
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